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Wyniki wyszukiwania dla: agro-food products
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Forced degradation studies of ivabradine and in silico toxicology predictions for its new designated impurities
PublikacjaAll activities should aim to eliminate genotoxic impurities and/or protect the API againstdegradation. There is a necessity to monitor impurities from all classification groups,hence ivabradine forced degradation studies were performed. Ivabradine was provedto be quite durable active substance, but still new and with insufficient stability data.Increased temperature, acid, base, oxidation reagents and...
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Consequences of New Approach of Chemical Stability Tests of Active Pharmaceutical Ingredients (APIs)
PublikacjaThere is a great need of broaden look on stability tests of active pharmaceuticalingredients (APIs) in comparison with current requirements contained in pharmacopeia.By usage of many modern analytical methods the conception of monitoring the changesof APIs during initial stage of their exposure to harmful factors has been developed. Newknowledge must be acquired in terms of identification of each degradation...
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Synthesis and structural characterization of bio-based bis(cyclic carbonate)s for the preparation of non-isocyanate polyurethanes
PublikacjaBio-based cyclic carbonates are of significant research interest as monomers for non-isocyanate polyurethane (NIPU) synthesis. This research describes the synthesis of a series of five-membered bis(cyclic carbonate)s using bio-based polyether polyols (PO3G) with different molecular weights (250, 650 and 1000 g mol−1) and carbon dioxide as green feedstocks. The utilization of CO2 as a source of carbon in the chemical reaction is...
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Żywność funkcjonalna- najważniejsze osiągnięcia w zakresie badań i wykorzystania
PublikacjaW wielu ośrodkach naukowych trwają badania ukierunkowane na poznanie mechanizmów działania składników żywności funkcjonalnej na poziomie ekspresji genetycznej, co stwarza możliwość precyzyjniejszego scharakteryzowania funkcji bioaktywnych składników diety z uwzględnieniem zmienności genetycznej populacji. Daje to w efekcie bardziej wiarygodne wyniki badań naukowych dotyczących wpływu bioaktywnych składników diety na funkcjonowanie...
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Klasyfikacja wyrobów tytoniowych z wykorzystaniem elektronicznych nosów
PublikacjaZapobieganie nielegalnej dystrybucji wyrobów tytoniowych w Polsce stanowi poważny problem. Wyroby tytoniowe przemycane do Polski mogą charakteryzować się niższą jakością, wynikającą z wykorzystania surowców gorszego gatunku. Jednym z rozwiązań zmniejszających skalę tego problemu mogą być działania ograniczające przemyt przez granice państwa. Autorzy pracy uważają, że wykorzystanie elektronicznych nosów do rutynowych kontroli przewożonych...
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New conjugates of mycophenolic acid and their antiproliferative activity
PublikacjaThe new conjugates of mycophenolic acid (MPA) were obtained in the reaction of N6-(ω-aminoalkyl)adenosines with MPA in the presence of EDCI as a coupling reagent. New compounds 4a–h were evaluated on leukemia cell line (Jurkat) and PBMC from healthy donors. Length of the linker influenced observed activity. The compound 4b possessing 1,3-diamine spacer exhibited the most promising results and can be considered to further investigations.
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New potent STS inhibitors based on fluorinated 4-(1-phenyl-1H-[1,2,3]triazol-4-yl)-phenyl sulfamates
PublikacjaA series of fluorinated analogs based on the frameworks of 4-(1- phenyl-1H-[1,2,3]triazol-4-yl)-phenyl sulfamates have been synthesized as steroid sulfatase (STS) inhibitors. The design of chemical structures of new potential STS inhibitors was supported by molecular docking techniques to identify potential interactions between inhibitors and amino acid residues located in the STS active site. The STS inhibitory potency was evaluated...
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Synthesis and antiproliferative activity of new mycophenolic acid conjugates with adenosine derivatives
PublikacjaNew conjugates of mycophenolic acid (MPA) and adenosine derivatives were synthesized and assessed as potential immunosuppressants on Jurkat cell line and peripheral blood mononuclear cells (PBMC) from healthy donors. As compared to MPA, all compounds were found to be more active against Jurkat cell line. The antiproliferative activities were compared with MPA and adenosine, in both 2′,3′-O-isopropylidene protected and free hydroxyl...
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Synthesis and biological evaluation of thiophosphate tricyclic coumarin derivatives as steroid sulfatase inhibitors
PublikacjaSteroid sulfatase (STS) enzyme inhibition is an important approach to the management of hormone-dependent breast cancer. In this paper, we report convenient methods for the synthesis and biological evaluation of thiophosphate tricyclic coumarin analogs exhibiting STS activity. The described methods are based on the straightforward preparation of 7-hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-2-one, 3-hydroxy- 7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one,...
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Innowacje jako przedmiot obrotu rynkowego
PublikacjaW artykule podjęto problem cech innowacji jako produktów, które na świecie, coraz częściej również w Polsce, stają się przedmiotem obrotu rynkowego. Różnią się zdecydowanie od produktów, oferowanych przez przedsiębiorstwa produkcyjno-usługowe na rynkach dóbr konsumpcyjnych, także gotowych dóbr przemysłowych. Kluczowe różnice wynikają z tego, że innowacja może być produktem - przedmiotem obrotu rynkowego już jako idea i koncepcja,...
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Efficient Selenenylation of Malonates Using Bis(phosphorothioyl) Diselenide
PublikacjaBis(O,O-diisopropoxyphosphinothioyl) diselenide reacts readily and quickly with the sodium salt of malonates to give quantitatively stable sodium 2-(O,O-diisopropyl phosphorothioselenenyl)propanedioates. No traces of the corresponding C,C-diselenenylation products were detected. A standard aqueous workup procedure affords the products, albeit in poor yield (about 45%). It was proved that the reaction is reversible due to the presence...
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Smart innovation process enhancement using SOEKS and decisional DNA
PublikacjaProduct innovation always requires a foundation based on both knowledge and experience. The production and innovation process of products is very similar to the evolution process of humans. The genetic information of humans is stored in genes, chromosomes and DNA. Similarly, the information about the products can be stored in a system having virtual genes, chromosomes and decisional DNA (DDNA). The present paper proposes...
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Synthesis of reduced graphene oxide nanosheets using nanofibers from methane and biogas thermal decomposition with various catalysts
PublikacjaReduced graphene oxide and graphene oxide (rGO, GO) were synthesised from carbon nanofibers, which were formed in catalytic thermal decomposition of methane (CDM) and biogas with different catalysts used in the process. The aim of the work was valorization of CDM carbon nanofiber products. The samples were characterized using Raman spectra, a scanning electron microscope and a transmission electron microscope. As a result, we observe...
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Framework for Product Innovation Using SOEKS and Decisional DNA
PublikacjaProduct innovation always requires a foundation based on both knowledge and experience. The production and innovation process of products is very similar to the evolution process of humans. The genetic information of humans is stored in genes, chromosomes and DNA. Similarly, the information about the products can be stored in a system having virtual genes, chromosomes and decisional DNA. The present paper proposes a framework for...
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Factors disturbing Internet usage in opinion of elderly users
PublikacjaInternet became truly widespread in modern societies. This created its huge economic potential, which is widely used, especially in traditionally communication-oriented societies like USA and Scandinavian countries. This trend enables to create economic growth even despite of worldwide economic slowdown.Together with demographic changes this raise the necessity of research on how older users perceive modern, Internet-based tools...
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Comparative Study of the Reinforcement Type Effect on the Thermomechanical Properties and Burning of Epoxy-Based Composites
PublikacjaAramid (AF), glass (GF), carbon (CF), basalt (BF), and flax (FF) fibers in the form of fabrics were used to produce the composites by hand-lay up method. The use of fabrics of similar grammage for composites’ manufacturing allowed for a comprehensive comparison of the properties of the final products. The most important task was to prepare a complex setup of mechanical and thermomechanical properties, supplemented by fire behavior...
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Glucosinolates from lepidium peruvianum as potential antiamnestic drugs
PublikacjaLepidium peruvianum (maca) (Brassicaceae) is a naturally occurring plant mainly in the high Andes of Peru. In recent years, it has been intensively researched in terms of its influence on various diseases and towards health improvement. Alzheimer’s disease is an incurable disease that most often affects adults over the age of 60. As since 2003 the US Food and Drug Administration (FDA) did not approve any new drug for Alzheimer’s...
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ANFIS-Based NPC Population Control in Video Games
PublikacjaModern computer games aim at providing rich, vivid worlds. The aim is to encourage the player to explore and interact with the in-game world. To describe the complex relations between in-game NPCs and their surrounding fuzzy logic is used. The paper presents ANFIS based population control in the video game. We present an approach allowing stabilizing the number of NPCs in-game by providing a certain amount of food to the environment....
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Analysis of Agricultural and Engineering Systems using Simulation Decomposition
PublikacjaThis paper focuses on the analysis of agricultural and engineering processes using simulation decomposition (SD). SD is a technique that utilizes Monte Carlo simulations and distribution decomposition to visually evaluate the source and the outcome of different portions of data. Here, SD is applied to three distinct processes: a model problem, a nondestructive evaluation testing system, and an agricultural food-water energy system....
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Dobór geotekstyliów i wyrobów pokrewnych pełniących funkcję zbrojenia w budownictwie komunikacyjnym – wybrane problemy inżynierskie
PublikacjaZ uwagi na odpowiedzialność uczestników procesu budowlanego za realizowane inwestycje komunikacyjne w coraz dłuższym horyzoncie czasowym, celowe wydaje się zwrócenie uwagi na zagadnienia związane z obserwowanymi niestety nadal problemami dotyczącymi umiejętności odróżniania poszczególnych rodzajów geosyntetyków oraz weryfikacji wymaganych w projekcie tzw. technicznych parametrów istotnych (np. wytrzymałość długoterminowa w przypadku...
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Thermal treatment of montmorillonite modified with Cd[SC(NH2)2]42+ from two polymorphic salts
PublikacjaMontmorillonite(MMT)/CdS nanocomposites can be obtained using simple ionic exchange between Na(I)-MMT and Cd[SC(NH2)2]42+∙2NO3. The resulting products may be annealed to give (MMT)/CdS nanocomposites as it was proved by XRD analysis.
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The impact of sediment, fresh and marine water on the concentration of chemical elements in water of the ice-covered lagoon
PublikacjaThe common use of chemical elements by man has been contributing to their extraction for centuries. As a consequence, they have been directly or indirectly introduced into the biogeochemical cycle. In the framework of many conventions, mining and processing of elements are currently subject to many restrictions. However, their large load that has already been deposited in the soil and bottom sediments can be remobilised and...
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Carbon nanowalls: A new versatile graphene based interface for laser desorption/ionization-mass spectrometry detection of small compounds in real samples.
PublikacjaCarbon nanowalls, vertically aligned graphene nanosheets, attract attention owing to their tunable band-gap, high conductivity, high mechanical robustness, high optical absorbance and other remarkable properties. In this paper, we report for the first time, the use of hydrophobic boron-doped carbon nanowalls (CNWs) for laser desorption/ionization of small compounds and their subsequent detection by mass spectrometry (LDI-MS). The...
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Genotoxic properties of glucosinolates and isothiocyanates present in Brassica vegetables
PublikacjaThe bioactive phytochemicals found in Brassica vegetables, in this number glucosinolates (GLS), as well as products of their degradation such as isothiocyanates (ITC) and indoles, are regarded as the most promising chemopreventive compounds. These secondary metabolites display stron antibiological activity and constitute defence system preventing the development of agrophages attacking Brassica plants. Such properties suggest...
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Development of Intelligent Road Signs with V2X Interface for Adaptive Traffic Controlling
PublikacjaThe objective of this paper is to present a practical project of intelligent road signs, under which a series of new products for the regulation of traffic is being created. The engineering part of the project, described in this paper, was preceded by a series of experimental studies, the results of which were described in another paper accepted for publication at the MTS-ITS conference 2019, entitled "Comparative study on the effectiveness...
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Electrochemical and in silico approaches for liver metabolic oxidation of antitumor-active triazoloacridinone C -1305
Publikacja5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) is a promising antitumor compound developed in our laboratory. A better understanding of its metabolic transformations is still needed to explain the multidirectional mechanism of pharmacological action of triazoloacridinone derivatives at all. Thus, the aim of the current work was to predict oxidative pathways of C-1305 that would reflect its phase I metabolism. The...
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The treatment of wastewater containing pharmaceuticals in microcosm constructed wetlands: the occurrence of integrons (int1–2) and associated resistance genes (sul1–3, qacEΔ1)
PublikacjaThe aim of this study was to analyze the occurrence of sulfonamide resistance genes (sul1–3) and other genetic elements as antiseptic resistance gene (qacEΔ1) and class 1 and class 2 integrons (int1–2) in the upper layer of substrate and in the effluent of microcosm constructed wetlands (CWs) treating artificial wastewater containing diclofenac and sulfamethoxazole (SMX), which is a sulfonamide antibiotic. The bacteria in the substrate...
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The importance of CEFTA 2006 for Western Balkan countries
PublikacjaFree foreign trade is one of the most important issues all over the world. The impact of bilateral trade can be studied both from economic as well as political perspectives; when it improves economic development, it also creates the conditions for international stability. The aim of the article is to conduct a comparison of the changes to export trade flow in the Central European Free Trade Agreement 2006, with reference to countries...
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Challenges and opportunities related to the use of sewage sludge ash in cement-based building materials – A review
PublikacjaDue to the increasingly demanding legal regulations, regarding both sewage sludge (SS) and solid residues obtained during its thermal utilization processes, new solutions to limit their negative impact on the environment are sought. One approach that eliminates the risk of sewage sludge ash (SSA) is its use in cement building materials. The article contains a detailed literature review regarding the use of SSA in mortars and concretes,...
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Pyrolysis of Pruning Residues from Various Types of Orchards and Pretreatment for Energetic Use of Biochar
PublikacjaThe routine pruning and cutting of fruit trees provides a considerable amount of biowaste each year. This lignocellulosic biomass, mainly in the form of branches, trunks, rootstocks, and leaves, is a potential high-quality fuel, yet often is treated as waste. The results of a feasibility study on biochar production by pyrolysis of residues from orchard pruning were presented. Three types of biomass waste were selected as raw materials...
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Investigation of the Efficiency of a Dual-Fuel Gas Turbine Combustion Chamber with a Plasma‒Chemical Element
PublikacjaThe study is devoted to the possibility of increasing the efficiency of the working process in dual-fuel combustion chambers of gas turbine engines for FPSO vessels. For the first time, it is proposed to use the advantages of plasma‒chemical intensification of the combustion of hydrocarbon fuels in the dual-fuel combustion chambers, which can simultaneously operate on gaseous and liquid fuels. A design scheme of a combustion chamber...
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MATERIAŁY I ELEMENTY STOSOWANE DO WYKONANIA LEKKIEJ OBUDOWY cz. 1. Materiały metalowe
PublikacjaW artykule przedstawiono stosowane w lekkich obudowach materiały metalowe i kształtowane z nich wyroby. Omówiono charakterystyczne parametry i różnice technologiczne występujące w produkcji wyrobów. Przedstawiono ocenę odporności korozyjnej materiałów.
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Mass spectrometry based identification of geometric isomers during metabolic stability study of a new cytotoxic sulfonamide derivatives supported by quantitative structure-retention relationships
PublikacjaA set of 15 new sulphonamide derivatives, presenting antitumor activity have been subjected to a metabolic stability study. The results showed that besides products of biotransformation, some additional peaks occurred in chromatograms. Tandem mass spectrometry revealed the same mass and fragmentation pathway, suggesting that geometric isomerization occurred. Thus, to support this hypothesis, quantitative structure-retention relationships...
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Regulation of Cellular Redox Homeostasis by (–)-Epicatechin and Cocoa Extracts—A Pilot Study
PublikacjaCocoa polyphenols play an important role in protection against diseases in which oxidative stress is implicated as a causal or contributing factor. The main aim of this study was to elucidate the influence of different cocoa extracts and main cocoa bioactive compound (–)-epicatechin on cell growth and support of antioxidant cellular barrier in colon adenocarcinoma cell line model (HT29). Results show that the tested cocoa bioactivity...
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REGULATION OF CELLULAR REDOX HOMEOSTASIS BY (-)-EPICATECHIN AND COCOA EXTRACTS – PILOT STUDY
PublikacjaCocoa polyphenols play an important role in protection against diseases in which oxidative stress is implicated as a causal or contributing factor. The main aim of this study was to elucidate the influence of different cocoa extracts and main cocoa bioactive compound (–)-epicatechin on cell growth and support of antioxidant cellular barrier in colon adenocarcinoma cell line model (HT29). Results show that the tested cocoa bioactivity...
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Recent advances in assessing xenobiotics migrating from packaging material – A review
PublikacjaMigration of potentially toxic xenobiotics and their transformation products from packaging materials needs continuous monitoring efforts. This task requires utilizing both instrumental and biological methods as more and more novel materials reach market every year to serve consumers and reduce production costs. Unfortunately, these materials very often sneak past our legal regulations on their composition and emission of contaminants...
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Smart Virtual Product Development (SVPD) to Enhance Product Manufacturing in Industry 4.0
PublikacjaThis paper presents a system capable of enhancing product development process for industrial manufactured products. This system is known as Smart Virtual Product Development (SVPD), and it helps in decision making by using explicit knowledge of formal decision events. It stores and reuses the past decisional events or sets of experiences related to different activities involved in industrial product development process i.e. product...
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A grey box model of glucose fermentation and syntrophic oxidation in microbial fuel cells
PublikacjaIn this work, the fermentative and oxidative processes taking place in a microbial fuel cell (MFC) fed with glucose were studied and modeled. The model accounting for the bioelectrochemical processes was based on ordinary, Monod-type differential equations. The model parameters were estimated using experimental results obtained from three H-type MFCs operated at open or closed circuits and fed with glucose or ethanol. The experimental...
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Convenient and efficient N-methylation of secondary amines under solvent-free ball milling conditions
PublikacjaIn the present work, we report the development of a rapid, efcient, and solvent-free procedure for the N-methylation of secondary amines under mechanochemical conditions. After optimization of the milling parameters, a vibrational ball mill was used to synthesize 26 tertiary N-methylated amine derivatives in a short time of 20 min (30 Hz frequency) and high yields ranging from 78 to 95%. An exception was compounds having a hydroxyl...
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Testing for conformance of parallel programming pattern languages
PublikacjaThis paper reports on the project being run by TUG and IMAG, aimed at reducing the volume of tests required to exercise parallel programming language compilers and libraries. The idea is to use the ISO STEP standard scheme for conformance testing of software products. A detailed example illustrating the ongoing work is presented.
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Materiały i elementy stosowane do wykonania lekkiej obudowy. Cz. 2. Materiały ze szkła budowlanego
PublikacjaW artykule przedstawiono stosowane w lekkich obudowach materiały szklane i kształtowane z nich wyroby. Omówiono charakterystyczne parametry i różnice technologiczne występujące w produkcji wyrobów szklanych przeziernych. Przedstawiono parametry definiujące właściwości przegród wykonanych ze szkła.
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Materiały szklane w lekkiej obudowie. cz. 3. Cechy techniczne i użytkowe szyb
PublikacjaOmówiono wyroby ze szkła budowlanego i wymagania jekie muszą spełniać zanim zostaną użyte w obiektach budowlanych, szczególnie w zakresie tworzenia szklano-metalowych fasad współczesnych budynków wysokościowych jak i halowych.
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Dissemination.
PublikacjaArtykuł opisuje doświadczenia związane z realizacją projektu Leonardo da Vinci EMDEL European Model for Distance Education (2001-2005), w szczególności z działaniami dotyczącymi etapu partnerskiej wymiany kursów (sub-project "Exchange of products") oraz rozpowszechniania wyników projektu ("Dissemination").
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Phototransformation of three selected pharmaceuticals, naproxen, 17α-Ethinylestradiol and tetracycline in water: Identification of photoproducts and transformation pathways
PublikacjaTransformation products (TPs) may be formed during various processes, however, it was proved that one of the main mechanisms responsible for degradation of pharmaceuticals in natural waters is photolysis. Three compounds were selected, tetracycline (TC), 17-α-ethinylestradiol (EE2) and naproxen (NAP), for degradation experiments which were performed using a xenon lamp emitting light with a spectrum closely approximating that of...
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Charge Transfer, Complexes Formation and Furan Fragmentation Induced by Collisions with Low-Energy Helium Cations
PublikacjaThe present work focuses on unraveling the collisional processes leading to the fragmentation of the gas-phase furan molecules under the He+ and He2+ cations impact in the energy range 5–2000 eV. The presence of different mechanisms was identified by the analysis of the optical fragmentation spectra measured using the collision-induced emission spectroscopy (CIES) in conjunction with the ab initio calculations. The measurements of...
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Bee Bread Exhibits Higher Antimicrobial Potential Compared to Bee Pollen
PublikacjaThis study aimed at investigation of the antimicrobial potential of ethanolic extracts of bee bread (BB) and bee pollen (BP) and suspensions of these products in MHB (Mueller Hinton Broth). We covered 30 samples of BP and 19 samples of BB harvested in Polish apiaries. Slightly lower activity was observed against Gram-negative bacteria compared to Gram-positive staphylococci. BB extracts exhibited higher inhibitory potential with...
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NEW PRODUCT DEVELOPMENT FROM THE PERSPECTIVE OF CREATING A COMPETITIVE ADVANTAGE
PublikacjaIt is acknowledged that achieving product-based competitive advantage is a key task for a company. However, there is still a research gap in determining those specific actions in the process of developing new products that arise from companies' efforts to achieve product-based competitive advantage. Therefore, the aim of this study is to determine the specific actions in the new product development (NPD) process that result from...
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Taq DNA polymerase fused with DNA binding protein with increased resistance to inhibitors from clinical samples
PublikacjaNowadays PCR method is commonly used in molecular diagnostic. However, in many cases PCR is limited, by the presence of inhibitory substances in biological, soil or food samples Efficiency and fidelity of amplification is strongly connected with DNA polymerase and reaction conditions. To meet the requirements of modern diagnostic methods it is essential to seeking for new DNA polymerases with better properties useful in these field....
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Mobile wireless measurement system for potatoes storage management
PublikacjaThe paper discusses the idea and the design of a remote control system for a storage management of agricultural products which temperature may rise in a result of biological processes during the storage. Exemplary potatoes storehouse is discussed as an application of the automation system. Because of existing buildings and infrastructure in the farm, wireless data transfer system has been proposed for both sensors to data acquisition...
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Determination of heavy metals in eyeshadows from China
PublikacjaPersonal care products and cosmetics are used daily by many people, causing local exposure to certain chemical substances through the application directly inside the oral cavity, on the skin, lips, eyes, and mucosa. Eyeshadows are among the most commonly used types of cosmetics. According to scientifc reports, they may contain heavy metals, especially in non-original products. The exposure to said heavy metals may cause local skin...