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New generation speech aid for stuttering people
PublikacjaWspółczesne Cyfrowe Procesory Sygnałowe (ang. DSP) mają niewielkie wymiary, ale są w stanie re-alizować złożone algorytmy. Ich dodatkową zaletą jest łatwość wymiany oprogramowania, a co za tym idzie łatwość zmiany dziedziny zastosowań. Wykorzystując możliwości procesów stało się możliwe budowanie miniaturowych protez słuchu i mowy. W referacie skupiono się na zagadnieniach związanych z projekto-wanie i implementacją algorytmów...
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Combined partial denitrification/anammox process for nitrogen removal in wastewater treatment
PublikacjaRecently, the combined partial denitrification and anammox (PD/anammox) has received special attention as a viable alternative for N removal using organic matter present in municipal wastewater. In comparison with conventional nitrification-denitrification, PD/anammox provides enormous opportunities to achieve sustainable wastewater treatment due to the lack of dissolved oxygen (DO) demand, a smaller amount of organic carbon (C)...
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Nonprotein nitrogenous compounds
PublikacjaThe non-protein nitrogen (NPN) fraction is an important group of food components for both technological and nutritional reasons. Free amino acids (FAAs), oligopeptides, amines, nucleic acids, and nucleotides, as well as other low-molecular nitrogen-containing components (cyanogenic glycosides, alkaloids, thiazoles, oxazoles, pyrroles, and pyrazines), are found in most foods. Their content depends on many factors, starting from...
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A city and a wind farm. Landscape perspective
PublikacjaThe aim of the paper is to present the problems of the location of the wind farms in close neighbourhood to the historical cities, and the ways to minimize the potential landscape threats. The production of clean energy is obligatory in EU. In spite of how positive to the environment the wind energy production is, it may cause negative effects. The results of landscape studies of two towns in Poland prove that the location of such...
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A new division of bacterial UvrA homologues
PublikacjaThe UvrA protein is a DNA-binding and damage-recognition enzyme which participates in the prokaryotic type nucleotide excision repair (NER) pathway. It has recently been noted that some bacterial genomes comprise additional uvrA genes which encode five distinct types of UvrA homologue. We investigated the sequences of over 2400 bacterial genomes and found 130 examples of bacteria containing uvrA 2 genes. The sequence analyses conducted...
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Selected Methods for the Chemical Phosphorylation and Thiophosphorylation of Phenols
PublikacjaThis Focus Review gathers together a selection of methods for the chemical phosphorylation of phenols that employ three‐ and four‐coordinate phosphorus compounds. Phosphorylated scaffolds can exhibit enhanced properties compared to their non‐phosphorylated analogues, such as increased biological activity and increased/decreased solubility; as such, phosphorus compounds have gained more and more interest in organic and medicinal...
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Efficient three-dimensional fluorescence measurements for characterization of binding properties in some plants
PublikacjaThe main aim of this research was to characterize some plants and to determine their similarities and differences, using spectroscopic methods. The interactions of soluble polyphenols of different plants with human serum albumin (HSA) were investigated by 3D-fluorescence. The obtained fluorescence results allow to classify the investigated plants according to their binding properties. The HSA-binding capacities of these plants...
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Effect of microwave and convection heating on selected nutrients of human milk
PublikacjaThe aim of this study was to determine the influence of the microwave heating method (MWH) on selected determinants of the nutritional value of human milk (HM) and compare to the effect exerted by the standard convection heating (CH) method, including holder pasteurization (HoP). It was showed that using MWH under conditions assumed to ensure microbiological safety, changes in the level of the nutrients were not observed. In these...
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Intelligent Autonomous Robot Supporting Small Pets in Domestic Environment
PublikacjaIn this contribution, we present preliminary results of the student project aimed at the development of an intelligent autonomous robot supporting small pets in a domestic environment. The main task of this robot is to protect a freely moving small pets against accidental stepping on them by home residents. For this purpose, we have developed the mobile robot which follows a pet and makes an alarm signal when a human is approaching....
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Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7
Publikacjanthrapyridazones, imino analogues of anthraquinone, constitute a family of compounds with remarkable anti-cancer activity. To date, over 20 derivatives were studied, of which most displayed nanomolar cytotoxicity towards broad spectrum of cancer cells, including breast, prostate and leukemic ones. BS-154, the most potent derivative, had IC50 values close to 1 nM, however, it was toxic in animal studies. Here, we characterize another...
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Imidazoacridinone antitumor agent C-1311 as a selective mechanism- based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.
Publikacja5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311), a promising antitumor agent that is also active against autoimmune diseases, was determined to be a selective inhibitor of the cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1311 might modulate the effectiveness of other drugs used in multidrug therapy. The present work aimed to identify the mechanism of the observed C-1311-mediated inactivation of CYP1A2...
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Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid
PublikacjaBackground: Although Mycophenolic Acid (MPA) is applied as prodrugs in clinic as an immunosuppressant, it also possesses anticancer activity. MPA acts as Inosine-5’-Monophosphate Dehydrogenase (IMPDH) inhibitor, where the carboxylic group at the end of the side chain interacts with Ser 276 of the enzyme via hydrogen bonds. Therefore, MPA derivatives with other polar groups indicated high inhibition too. On the other hand, potent...
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Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: characteristics of non-enzymatic and glutathione S-transferase-mediated reactions
PublikacjaUnsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes. The aim of this work was to investigate the GSH-mediated metabolic pathway of a representative UA, C 2028. GSH supplemented incubations of C-2028 with rat, but not with human, liver...
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Between therapy effect and false-positive result in animal experimentation
PublikacjaDespite the animal models’ complexity, researchers tend to reduce the number of animals in experiments for expenses and ethical concerns. This tendency makes the risk of false-positive results, as statistical significance, the primary criterion to validate findings, often fails if testing small samples. This study aims to highlight such risks using an example from experimental regenerative therapy and propose a machine-learning...
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O problemie kolmatacji geowłóknin stosowanych w drenażach
PublikacjaSystemy drenażowe występujące przy obiektach drogowych są niezwykle istotnym elementem tych budowli. Jednym z materiałów, które obecnie powszechnie stosowane są w systemach drenażowych są geowłókniny. Ich zadaniem jest zabezpieczenie odwadnianego gruntu przed procesem sufozji, jak również ochrona drenażu przed zamuleniem przy jednoczesnym zachowaniu wodoprzepuszczalności. Typową trwałość drenażu, w zależności od rozwiązań, szacować...
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Vibration monitoring of structures in the light of the Polish and international requirements
PublikacjaThe paper concerns the wide range of strategies used to protect structures against man-made dynamic excitation. The most popular approaches applied worldwide are compared, and the main differences and similarities are summarized. The literature studies are supported by the results of the measurements performed on different types of real structures, which are sensitive and insensitive to the dynamic load. To make the conclusions...
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Reactions on the surface of the implant under the influence of biofilm
PublikacjaThe contact of a biomaterial with the biological environment in in vitro and in vivo tests leads to the production of a particular ecosystem in which the active roles perform both, the material surface and the extracellular matrix protein forming a biofilm. Proteins affect cell and bacteria adhesion processes, biological activity of cells and activation of inflammatory response.The knowledge of the reaction mechanisms active on...
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Structure of EstA esterase from psychrotrophic Pseudoalteromonas sp. 643A covalently inhibited by monoethylphosphonate.
PublikacjaThe crystal structure of the esterase EstA from the cold-adapted bacteriumPseudoalteromonas sp. 643A was determined in a covalently inhibited form at aresolution of 1.35 A˚. The enzyme has a typical SGNH hydrolase structureconsisting of a single domain containing a five-stranded beta-sheet, with threehelices at the convex side and two helices at the concave side of the sheet, and isornamented with a couple of very short helices...
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Molecular identification and genotyping of Staphylococci: genus, species, strains, colnes, lineages, and interspecies exchanges
PublikacjaStaphylococci are increasingly recognized as etiological agents of many opportunistic human and animal infections, emphasizing the need for a rapid and accurate identification, even to a genotypical level of these bacteria. In the recent years, there has been a significant progress in typing and phylogenetic study of Staphylococcus species. Here, we describe molecular methods used in taxonomy as well as staphylococci characterization....
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Role of Human UDP-Glucuronosyltransferases in the Biotransformation of the Triazoloacridinone and Imidazoacridinone Antitumor Agents C-1305 and C-1311 : Highly Selective Substrates for UGT1A10
Publikacja5-Diethylaminoethylamino-8-hydroxyimidazoacridinone, C-1311 (NSC-645809), is an antitumor agent shown to be effective against breast cancer in phase II clinical trials. A similar compound, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone, C-1305, shows high activity against experimental tumors and is expected to have even more beneficial pharmacological properties than C-1311. Previously published studies showed that these...
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Voltammetric and biological studies of folate-targeted non-lamellar lipid mesophases
PublikacjaFolate-targeted lipid nanostructures are promising strategies for the development of biocompatible drug delivery systems. The objective of this study was to evaluate the efficacy of drug delivery to cancer cells by folate-targeted lipid mesophases, cubosomes (CUB) and hexosomes (HEX), loaded with doxorubicin (DOX). Three cancer-derived cell lines (KB, HeLa, T98G) exhibiting different expressional levels of folate receptor protein...
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Diamond Nanofilm Normalizes Proliferation and Metabolism in Liver Cancer Cells
PublikacjaPurpose: Surgical resection of hepatocellular carcinoma can be associated with recurrence resulting from the degeneration of residual volume of the liver. The objective was to assess the possibility of using a biocompatible nanofilm, made of a colloid of diamond nanoparticles (nfND), to fill the side after tumour resection and optimize its contact with proliferating liver cells, minimizing their cancerous transformation. Methods:...
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The antitumor compound triazoloacridinone C-1305 inhibits FLT3 kinase activity and potentiates apoptosis in mutant FLT3-ITD leukemia cells.
PublikacjaAim: FMS-like receptor tyrosine kinase (FLT3) is expressed in some normal hematopoietic cell types and plays an important role in the pathogenesis of acute myeloid leukemia (AML). In this study, we examined the effects of triazoloacridinone C-1305, an antitumor compound, on AML cells with different FLT3 status in vitro. Methods: A panel of human leukemic cell lines with different FLT3 status was used, including FLT3 internal tandem...
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The Antimicrobial Potential of Bacteria Isolated from Honey Samples Produced in the Apiaries Located in Pomeranian Voivodeship in Northern Poland
PublikacjaThe principal objective of this study was to determine whether the honeys produced in apiaries located in Pomeranian Voivodeship (Northern Poland) contain bacteria producing metabolites with growth inhibition potential against important human and animal pathogens. The pathogens included Staphylococcus aurues, Staphyloccocus epidermidis, Escherichia coli, Listeria monocytogenes, Pseudomonas aeruginosa, and Candida albicans. From...
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Targeting shelterin proteins for cancer therapy.
PublikacjaAs a global health challenge, cancer prompts continuous exploration for innovative therapies that are also based on new targets. One promising avenue is targeting the shelterin protein complex, a safeguard for telomeres crucial in preventing DNA damage. The role of shelterin in modulating ataxia- telangiectasia mutated (ATM) and ataxia-telangiectasia and Rad3-related (ATR) kinases, key players in the DNA damage response (DDR),...
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Annual changes of basic parameters of bottom sediments from the Klodnica River Catchment
PublikacjaThe Klodnica River Catchment is heavily contaminated ecosystem located in area of the Upper Silesia Industrial Region. In this area various forms of human activity can be observed (e.g. mining coal underground, metallurgy, power/heat plants, wastewater discharged directly into the river). The impact of industrial and municipal wastes on this aquatic system causes to changes in the hydrographic network of river and the waters quality. In...
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Laboratory assessment of permeability of sand and biopolymer mixtures
PublikacjaLaboratory assessment of permeability of sand and biopolymer mixtures. This research presents a method of creating seepage barriers in a sandy soil using biopolymer additives (biosubstance), which consist of polysaccharides and water. Polysaccharides strongly interact with water to produce a viscous suspension. The paper aims to investigate the infl uence of a biosubstance employed in a highly permeable sandy soil. Amount of the...
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Biofilm Production and Presence of ica and bap Genes in Staphylococcus aureus Strains Isolated from Cows with Mastitis in the Eastern Poland
PublikacjaThe aim of the study was phenotypic and genotypic analysis of 132 S. aureus strains isolated from mastitis in eastern Poland in respect to their biofilm formation ability. The analysis of the size polymorphism of fragment X in the gene encoding protein A (spa) revealed high genetic differentiation of the analyzed group of isolates. The ability of biofilm formation by the isolates was tested using two phenotypic methods. The Congo...
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Operational problems of constructed wetland for landfill leachates treatment: case study
PublikacjaIn the paper the quality fluctuations of leachate from municipal landfill in Gdansk (Poland) over the last 5 years and evaluation of a wetland system designed for treatment of the leachate are discussed.The research has been conducted during the 5 years period. The constructed wetland for leachate treatment, consisting of 2 horizontal subsurface flow reed beds, working in parallel was built in 2001. In the period 2005-06 it underwent...
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Application of OFDM technique to underwater acoustic data transmission
PublikacjaPerformances of underwater acoustic communication (UAC) digital systems are strongly related to specific transmission properties of the underwater channel. Depending on the characteristics of the channel, an architecture and modulation techniques are usually implemented that are known as reliable solutions for data transmission in difficult radio channels. The OFDM technique seems to be the most promising nowadays. The parameters...
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Aminy w środowisku - niebezpieczeństwo czy jego naturalny element?
PublikacjaA lot of amines and their compounds are used in the industry. First of all they are used for the preparation of medicines, plant protection agents, fertilizers and plastics. Amines are also released into the environment as a result of natural biological processes such as the release of certain species of flowers to lure insects, and also biochemical breakdown of amino acids in the protein during decomposition of organic matter. Unfortunately,...
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A fair distribution scheme for joint fingerprinting and decryption methods= Sprawiedliwy schemat dystrybucji dla metod łącznego osadzania odcisku palca oraz deszyfracji
PublikacjaThe paper addresses the fairness of the security provided by digital fingerprinting methods. It was noted that the digital fingerprinting techniques are designed primarily to protect service providers against the actions of malicious users, while honest users remain vulnerable to acts of malicious providers. The paper describes the customer's rights problem and the unbinding problem, which also apply to joint fingerprinting and...
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Metal-Organic Frameworks-Based Sensors for the Detection of Toxins in Food: A Critical Mini-Review on the Applications and Mechanisms
PublikacjaUsing scientific technologies to detect toxins in food is significant to prevent food safety problems and protect people’s health. Recently, the rise of sensors has made rapid, efficient, and safe detection of food toxins possible. One of the key factors impacting the sensor’s performance is the nanomaterials employed. Metal-organic frameworks (MOFs), with high specific surface area, tunable composition, porous structure, and flexible...
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Tetracycline and ampicillin resistance of Escherichia coli strains of surface water origin: the potential for horizontal transfer of resistance genes = Oporność na tetracyklinę i ampicylinę szczepów Escherichia Coli wyizolowanych z wody powierzchniowej : możliwość horyzontalnego przenoszenia genów oporności
PublikacjaThe aim of this preliminary study was to assess the occurrence and molecular diversity of tetracycline and ampicillin resistance genes carried by Escherichia coli present in surface water. Bacterial strains were isolated from two watercourses (the Reda River and the Oliwski Stream) that influence the quality of coastal waters in the Gdańsk Bay (Northern Poland) by direct discharge. The bacterial drug susceptibility, tested against...
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New Chalcones Derivatives With Potent Antitumor Activity And Their Metabolism In Vitro
PublikacjaChalcone derivatives exhibit a broad range of biological activities, with antioxidant and cytotoxic properties among the most studied. Despite numerous reports on chalcones as cytotoxic, and potentially anticancer agents, very little is know on their actual mechanism of activity. Generally, chalcones are considered as antimitotic agents, which interfere with tubulin assembly.We have recently developed a new class of chalcones with...
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Host and pathogen factors in Klebsiella pneumoniae upper urinary tract infections in renal transplant patients
PublikacjaPurpose . To analyse the role of virulence factors (VFs) and host in Klebsiella pneumoniae upper urinary tract infections (UTIs) in renal transplant (RTx) recipients. Methodology. Clinical and demographic data were registered prospectively. Phylogenetic background of K. pneumoniae isolates was analysed by PCR melting profiles (MP) and the following VFs genes: fimH-1, uge, kpn, ycfM, mrkD, rmpA, magA, hlyA, cnf-1, irp-1, irp-2,...
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Incorporation of the sulfur cycle in sustainable nitrogen removal systems - A review
PublikacjaIn wastewater treatment systems, sulfur (S) removal processes are generally based on heterotrophic sulfate (SO42−) reduction by sulfate reducing bacteria and S-dependent autotrophic denitrification by sulfur oxidizing bacteria. A combination of either two cycles (N and S) or three cycles (N, S and C) appears to be a viable approach to sustainable wastewater treatment, resulting in energy savings and reduction of sludge production....
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Properties and applications of thermostable proteases sourced from Deinococcus geothermalis.
PublikacjaThe growing interest of extremophiles results from the fact that their enzymes arestable and active under harsh environment conditions. These type of biocatalysts are attractivedue to the fact that can be used in industrial processes that were previously regarded asincompatible with biological materials. Among extremozymes the largest group constitutethermozymes. Currently it is estimated that approximately 40% of enzymes used...
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Comparison of the main bioactive compounds and antioxidants in garlic and white and red onion after treatment protocols
PublikacjaPolski czosnek, biała i czerwona cebula była blanszowana, gotowana, smażona i poddawana działaniom promieniowania mikrofalowego. Następnie były w nich oznaczane m.in. takie związki jak polifenole, flawonoidy, kwas ascorbinowy i aktywne antyoksydanty. Udowodniono, że blanszowanie, smażenie i poddawanie działaniu promieniowania mikrofalowego nie wpływa znacząco na zmiejszenie zawartości badanych związków w czosnku i cebuli. Wyznaczono...
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Greenness assessment of analytical methods used for antibiotic residues determination in food samples
PublikacjaFood of animal origin plays an important role in ensuring a healthy and sustainable human diet. However, residues of pharmaceuticals, especially antibiotics, can be the cause of many health problems. To protect consumers and improve food quality, analytical methods used to determine contaminants should be simple, selective, and have high throughput and low detection limits. Recently, greenness metric tools have proven useful in...
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Experiment with small objects floating under water in the harbor security aspect.
PublikacjaObservation of the underwater area is the element of general trend which primary purpose is to protect and enhance the safety of the selected region. The aim of the paper is to present the acoustic characteristics of typical objects floating on the surface or under the water, which constitute some knowledge on how to detect these objects. Create a catalog of acoustic signatures and acoustic images of objects mostly floating under...
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OPERATIONAL PROBLEMS OF CONSTRUCTED WETLAND FOR LANDFILL LEACHATE TREATMENT: CASE STUDY
PublikacjaThe present paper discusses the quality fluctuations of leachate from municipal landfill in Gdansk (Poland) over the last 5 years and the evaluation of a wetland system designed for treatment of the leachate. The research has been conducted during a 5-year period. The constructed wetland for leachate treatment was built in 2001; it consists of 2 horizontal subsurface flow reed beds, working in parallel. In the period 2005–2006...
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Air quality policy in the U.S. and the EU – a review
PublikacjaThe high level of atmospheric pollution is a global problem that has taken on particular significance in recent years and will continue to grow in the near future. Air pollution directly affects the health, living organisms, vegetation, water, soil and buildings. Additionally, it moves easily even over long distances. Certain air pollutants influence the climate, cause negative processes in the protective ozone layer and contribute...
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Determination of thiocyanate as a biomarker of tobacco smoke constituents in selected biological materials of human origin
Publikacjan order to protect human health, it is necessary to biomonitor toxic substances originating from tobacco smoke in biological materials sampled from persons with different exposures to tobacco smoke constituents. Thiocyanate anion is a biomarker of exposure to tobacco smoke components which is characterized by a relatively long half‐life in the human body, i.e. 6 days. In this work, we present the results of thiocyanate determinations...
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Influence of the ionic strength on the amyloid fibrillogenesis of hen egg white lysozyme
PublikacjaThe study investigates the role of the electrostatic interactions in the fibrillation of the hen egg white lysozyme (HEWL). In order to achieve this aim the influence of the cations Na+, Mg2+ and Al3+ on the amyloid fibril formation and amorphous aggregation was tested. The amyloids are formed in the solution without added salt but the Thioflavin T fluorescence gives the false-negative result. In these conditions, the HEWL fibrils...
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The Drop-in-Drop Encapsulation in Chitosan and Sodium Alginate as a Method of Prolonging the Quality of Linseed Oil
PublikacjaNowadays, the encapsulation of sensitive products by various techniques has become popular as a promising preservation method. In particular, this applies to oils with a high content of unsaturated fatty acids and a high susceptibility to deterioration. This work presents the possibility of using a chitosan and sodium alginate in the form of a hydrogel membrane to protect food ingredients such as linseed oil, which is stored in...
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A METHOD OF TRUST MANAGEMENT IN WIRELESS SENSOR NETWORKS
PublikacjaThe research problem considered in this paper is how to protect wireless sensor networks (WSN) against cyber-threats by applying trust management and how to strengthen network resilience to attacks targeting the trust management mechanism itself. A new method, called WSN Cooperative Trust Management Method (WCT2M), of distributed trust management in multi-layer wireless sensor networks is proposed and its performance is evaluated....
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The Boltzmann sequence-structure channel
PublikacjaWe rigorously study a channel that maps binary sequences to self-avoiding walks in the two-dimensional grid, inspired by a model of protein statistics. This channel, which we also call the Boltzmann sequence-structure channel, is characterized by a Boltzmann/Gibbs distribution with a free parameter corresponding to temperature. In our previous work, we verified experimentally that the channel capacity has a phase transition for...
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Ligand-Modified Boron-Doped Diamond Surface: DFT Insights into the Electronic Properties of Biofunctionalization
PublikacjaWith the increasing power of computation systems, theoretical calculations provide a means for quick determination of material properties, laying out a research plan, and lowering material development costs. One of the most common is Density Functional Theory (DFT), which allows us to simulate the structure of chemical molecules or crystals and their interaction. In developing a new generation of biosensors, understanding the nature...
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Optimization of Wireless Networks for Resilience to Adverse Weather Conditions
PublikacjaIn this chapter, we consider how adverse weather conditions such as rain or fog affect the performance of wireless networks, and how to optimize these networks so as to make them robust to these conditions. We first show how to analyze the weather conditions in order to make them useful for network optimization modelling. Using an example realistic network, we show how to optimize two types of wireless networks: free-space optical...