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Development of potent and effective SARS-CoV-2 main protease inhibitors based on maleimide analogs for the potential treatment of COVID-19
PublicationIn the present work, we report a new series of potent SARS-CoV-2 Main Protease (Mpro) inhibitors based on maleimide derivatives. The inhibitory activities were tested in an enzymatic assay using recombinant Mpro (3CL Protease from coronavirus SARS-CoV-2). Within the set of new Mpro inhibitors, 6e demonstrated the highest activity in the enzymatic assay with an IC50 value of 8.52 ± 0.44 mM. The IC50 value for Nirmatrelvir (PF-07321332,...
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The Belt and Road Initiative and export variety: 1996–2019
PublicationThis study examines the association between the Belt and Road Initiative (BRI) and export variety (EV). We propose three hypotheses on how BRI may foster export markets (destinations) or export product lines. The estimates are based on a dataset constructed specifically for this analysis, covering 183 countries and linked with trade data from 1996 to 2019. We apply the instrumental variable (IV) approach in regressions for covering the...
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Rapid Design Tuning of Miniaturized Rat-Race Couplers Using Regression-Based Equivalent Network Surrogates
PublicationA simple technique for fast design tuning of compact rat-race couplers is presented. Our approach involves equivalent circuit representation, corrected by nonlinear functions of frequency with coefficients extracted through nonlinear regression. At the same time, the tuning process connects two levels of coupler representation: EM simulation of the entire circuit and re-optimization of the coupler building blocks (slow-wave cells...
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The impact of material degradation on the resistance and reliability of truss structures
PublicationThe paper analyses limit load-carrying capacity and buckling load of truss towers used to support high voltage power lines. The analysed typical structure was subjected to characteristic loads and their combinations. The results were applied to assess structural resistance with regard to steel corrosion in the long-term operation. The extent of structural deterioration was assessed due to Young's modulus decrement in the course...
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Extended phase diagram of RNiC2 family: Linear scaling of the Peierls temperature
PublicationPhysical properties for the late-lanthanide-based RNiC2 (R = Dy, Ho, Er, and Tm) ternary compounds are reported. All the compounds show antiferromagnetic ground state with the Néel temperature ranging from 3.4 K for HoNiC2 to 8.5 K for ErNiC2. The results of the transport and galvanomagnetic properties confirm a charge density wave state at and above room temperature with transition temperatures TCDW = 284, 335, 366, and 394 K for...
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Complex Predictive Solution for Computerized Processes in Tire Industry
PublicationFollowing increasing market needs of productivity, cost reduction and safety requirements, computerized industry are faced to finding optimum between economic aspects of business and safety-related risk management. Modern factories equipped with computerized processes and extended diagnostic tools to support operator do not often use of all information’s which comes from the equipment. Some of the relations between the events are...
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Safety Assessment of Tram Stops
PublicationThe safety of public transport stops is the subject of numerous studies in large agglomerations around the world. This is due to the fact that it is a passenger exchange zone where collisions and accidents involving people getting on or off public transport vehicles most often occur. For this reason, the purpose of the article is to present the results of the safety assessment of the stop zones for two selected tram lines in Wroclaw....
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Dietary antioxidants as a source of hydrogen peroxide
PublicationStudies of 54 antioxidants revealed that 27 of them, mainly polyphenols, generated hydrogen peroxide (H2O2) when added to Dulbecco’s modified Eagle’s medium (DMEM), other media used for culture of mammalian and yeast cells and phosphate-buffered saline. The most active antioxidants were: propyl gallate (PG), (−)-epigallocatechin gallate (EGCG) and quercetin (Q). Chelex treatment and iron chelators decreased H2O2 generation suggesting...
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Porosity and swelling properties of novel polyurethane–ascorbic acid scaffolds prepared by different procedures for potential use in bone tissue engineering
PublicationIn this work, a novel polyurethane (PU) system based on poly(ethylene-butylene) adipate diol, 1,6-hexamethylene diisocyanate, 1,4-butanediol, and ascorbic acid was used to prepare scaffolds with potential applications in bone tissue engineering. Two fabrication methods to obtain porous materials were chosen: phase separation (PS)/salt particle leaching (PL) and solvent casting (SC)/salt PL. The calculated porosity demonstrated...
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OPERATING CONDITIONS OF SLIDE BEARINGS OF MILLS USED IN KGHM POLSKA MIEDŹ S.A.
PublicationThe paper contains the results from a tec hnical analysis of the conditions of the operation of hydrodynamic bearings supporting the drums of ore processing mills at KGHM Polska Mied ź S.A. A theoretical analysis was performed on the grounds of onsite examination and measurem ents of principal dimensions of the bearings of interest. The computer simulation covered the characteristics of the oil film in the bearings...
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A Simple-Topology Compact Broadband Circularly Polarized Antenna With Unidirectional Radiation Pattern
PublicationIn this letter, a geometrically simple, reflector-backed single-point-fed circularly polarized (CP) antenna with unidirectional radiation pattern is presented. The structure comprises a simple coplanar waveguide (CPW) feeding circuit with an open slot etched on one side of the coplanar ground. The enhanced CP bandwidth is obtained by combining the loop mode, the slot mode, and the asymmetrical configuration of the coplanar ground...
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Historic railway stations, documentation and revitalization of the railway infrastructure facilities - protection of cultural and social heritage
PublicationThe article presents problems of documentation and adaptation of buildings which constitute the cultural heritage of the railway infrastructure facilities in Pomerania in Poland. Shows the potential and possibilityto be adopted for various purposes. This problem affects many sites and buildings, railway stations, railway warehouses, residential buildings, technical buildings, water towers, trackman shelters, bridges, viaducts,...
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Fracture Energy of Bonded Joints with 2D Elastic Adhesive Layer
PublicationWhen bonded joint is subjected to mode I fracture loading, the adhesive joints analytical solutions treats the adhesive layer, usually, as not existing or 1D Hooke elastic layer. In the case of 1D elastic layer, represented as Hookes spring element, is acting, only, in direction contrary to the applied load. Basing on the information yielded from sensitive laser profilometry technique, where deflections of bonded part of the joint...
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Probabilistic Approach to Precipitation-Runoff Relation in a Mountain Catchment: A Case Study of the Kłodzka Valley in Poland
PublicationOn the basis of daily precipitation and discharges recorded in 1974–2013 relations between precipitation and runoff in the Kłodzka Valley (KV) in south-western Poland were analyzed. The degree of synchronicity between them was determined using the bivariate Archimedean copulas. This study aims at identifying and then describe in a probabilistic way the precipitation and runoff relations in the area playing an important role...
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Numerical investigation on dynamic response of a steel lattice tower under various seismic events
PublicationThe present paper presents the results of the numerical study designed to investigate the soil-structure flexibility effects on modal parameters (i.e. fundamental frequencies) and time-history analysis response (represented by the top relative displacements) of a 46.8 m high steel lattice tower subjected to a number of ground motions including also one mining tremor. In addition to the fixed-base condition, three different soil...
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Ocena kształtu geometrycznego torów tramwajowych na podstawie pomiarów satelitarnych
PublicationW pracy przedstawiono ocenę możliwości wykorzystania dwusystemowych fazowych odbiorników GNSS (GPS/Glonass) dla realizacji pomiaru inwentaryzacyjnego linii tramwajowych. Opisano przebieg pomiarów przeprowadzonych na terenie Gdańska i uzyskane wyniki. Wykazano, że dla obszarów miejskich zastosowanie rozwiązań GNSS w oparciu o lokalną stację referencyjną może być alternatywnym podejściem względem pomiarów opartych o sieć ASG-EUPOS...
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Current Source Inverter Fed Drive
PublicationThis book covers three-phase and multiphase (more than three-phase) motor drives including their control and practical problems faced in the field (e.g., adding LC filters in the output of a feeding converter), are considered. The new edition contains links to Matlab®/Simulink models and PowerPoint slides ideal for teaching and understanding the material contained within the book. Readers will also benefit from the inclusion of: A...
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Interplay between Aryl···Perfluoroaryl and Hydrogen Bonding Interactions in Cocrystals of Pentafluorophenol with Molecules of Trigonal Symmetry
PublicationCocrystals of seven star-shaped triaryl compounds with pentafluorophenol (pfp) were prepared and structurally characterized by the single-crystal X-ray diffraction method. Cocrystallization of pfp with planar (or almost planar) compounds gave six 3:1 molecular complexes with well-defined layered structures. The layers are composed of alternating pfp3 trimers, linked by hydrogen bonding, and triaryl molecules held together in planes...
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Mechanical Properties of 3D Printed Parts and Their Injection Molded Alternatives Subjected to Environmental Aging
PublicationAdditive manufacturing is the technology used in medical, industrial, or lifestyle applications. The scientific literature include works reporting various manufacturing parameters’ influence on changes in additive manufacturing components’ mechanical behavior, especially with fused filament fabrication (FFF). The changes in mechanical strength and toughness of FFF compared to injection molding parts were studied. In the study,...
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Influence of the electrosynthesis conditions on the spontaneous release of anti-inflammatory salicylate during degradation of polypyrrole coated iron for biodegradable cardiovascular stent
PublicationIn this work, the spontaneous release of anti-inflammatory salicylate from polypyrrole (PPy) coated iron has been studied during degradation of the material in phosphate buffer saline at 37 C. The sodium salicylate was incorporated into PPy in a one-step electropolymerization process. The influence of the synthesis conditions such as sodium salicylate concentration, pyrrole concentration and deposition charge on drug release profile...
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Using terrestrial laser scanning in inventorying of a hybrid constructed wetland system
PublicationThe goal of this paper was to evaluate the possibility of using terrestrial laser scanning (TLS) for inventorying of a hybrid constructed wetland (CW) wastewater treatment plant. The object under study was a turtle-shaped system built in 2015 in Eastern Poland. Its main purpose is the treatment of wastewater from theMuseumand Education Centre of Polesie National Park. The study showed that the CW system had been built in compliance...
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Longitudinally magnetized left-handed cylindrical ferrite coupled line junction for nonreciprocal devices
PublicationThis paper presents investigations of longitudinally magnetized left-handed cylindrical ferrite coupled line junction for nonreciprocal devices. The proposed junction is formed as a quasi periodic arrangement of N unit cells. Each unit cell is realized as a cascade of short cylindrical ferrite coupled lines with reactance circuit composed of series capacitors and parallel inductors. The left-handed cylindrical junction with π/4...
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Diagnostic testing of marine propulsion systems with internal combustion engines by means of vibration measurement and results analysis
PublicationIn this paper selected issues concerning vibration diagnosis of the mechanical system within marine propulsion units have been presented, carried out on the basis of experimental examinations of a real object in which an exceedance of the allowable vibration’s level had been observed. Used diagnosing system has been characterised. A procedure of longitudinal and transverse vibrations shaft lines of the mechanical system within...
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Generic emergence of classical features in quantum Darwinism
PublicationQuantum Darwinism posits that only specific information about a quantum system that is redundantly proliferated to many parts of its environment becomes accessible and objective, leading to the emergence of classical reality. However, it is not clear under what conditions this mechanism holds true. Here we prove that the emergence of classical features along the lines of quantum Darwinism is a general feature of any quantum dynamics:...
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Synthesis and biological evaluation of novel analogues of batracylin with synthetic amino acids and adenosine: an unexpected effect on centromere segregation in tumor cells through a dual inhibition of topoisomerase IIa and Aurora B
PublicationIn the search for new anticancer agents we designed and synthesized batracylin derivatives with linking synthetic amino acid side chains of different lengths and adenosine. Unexpectedly, we have found that in water and the culture media adenosine–amino acid–BAT conjugates form supramolecular structures and this prevents these compounds from entering cells. Consequently, these compounds exerted no biological activity when tested...
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A PRELIMINARY STUDY ON THE OPTIMAL CHOICE OF AN IMPLANT AND ITS ORIENTATION IN VENTRAL HERNIA REPAIR
PublicationThis paper addresses the problem of ventral hernia repair. The main goals are to find an optimal surgical mesh for hernia repair and to define its optimal orientation in the abdominal wall to minimise the maximum force at the tissue-implant juncture. The optimal mesh is chosen from a set of orthotropic meshes with different stiffness ratios for typical hernia placement in the abdominal area. The implant is subjected to an anisotropic...
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Estimation of the Maximum Permissible PV Power to be Connected to the MV Grid
PublicationIn recent decades, a significant increase in the share of renewable energy sources in power grids at various voltage levels has been observed. A number of articles have been published highlighting emerging problems in low-voltage grids with a large share of prosumers and in medium- and high-voltage grids to which photovoltaic (PV) plants are connected. The article analyzes the medium-voltage grid in terms of the possibility of...
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Protein overproduction alters exosome secretion in Chinese hamster ovary cells
PublicationDespite the abundance of available cell lines, nearly 70% of all recombinant therapeutic proteins today are produced in Chi-nese hamster ovary (CHO) cells. The impact of protein overproduction on the secretion of exosomes by CHO cells has been investigated here. Increased secretion of extracellular vesicles (EVs) by protein overexpressing CHO cells was demonstrated with protein content assay, nanoparticle tracking analysis, and...
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Chiral Pyrazolo[4,3-e][1,2,4]triazine Sulfonamides—Their Biological Activity, Lipophilicity, Protein Affinity, and Metabolic Transformations
PublicationReferring to our previous laboratory results related to the tyrosinase and urease inhibition by pyrazolo[4,3-e][1,2,4]triazine sulfonamides, we examined here in silico the mechanism of action at the molecular level of the investigated pyrazolotriazine sulfonamides by the molecular docking method. The studied compounds being evaluated for their cytotoxic effect against cancer cell lines (MCF-7, K-562) and for recombinant Abl and...
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Visualization of a lifeboat motion during lowering along ship’s side
PublicationThis paper presents description of a computer program for motion visualization of a lifeboat lowered along ship’s side. The program is a post-processor which reads results of numerical calculations of simulated objects’ motions. The data is used to create scene composed of 3D surfaces to visualize mutual spatial positions of a lifeboat, ship’s side and water waving surface. Since the numerical data contain description of a simulation...
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Study of ultraviolet-visible fluorescence emission following resonant Auger decay of the 2p-1nl core-excited states of argon atoms
PublicationWe have studied the excitation and relaxation of Ar+ ions populated in resonant Auger decay from the Ar 2p−1nl core-excited states by using ultraviolet-visible fluorescence spectroscopy and photon-photon delayed coincidence technique. Fluorescence emission yields were measured in the photon energy range of 240-–255 eV for the 3s23p4(1D)5s(2D) → 3s23p4(1D)4p(2F) (393 nm) and 3s23p4(1D)4d(2F) → 3s23p4(1D)4p(2F) (335 nm) transitions...
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Overheating of underground power cable line due to its partial exposition to solar radiation
PublicationCurrent-carrying capacity of underground power cable lines depends, among others, on thermal resistivity of the soil and cables layout: trefoil formation, flat formation with or without spacing. If conditions for heat transfer in the ground are favorable, the current-carrying capacity is relatively high. Therefore, it generates risk of the power cables overheating, if part of the cable line is located vertically in the air, to...
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Metoda określania maksymalnej prędkości jazdy na łukach, dostosowana do specyfiki tras tramwajowych
PublicationW artykule określono potrzebę obliczenia prędkości z jaką maksymalnie można poruszać się pojazdem tramwajowym na wybranych odcinkach trasy. Określono jakie wartości są niezbędne do wykonania obliczeń trakcyjnych. Dostosowano metodę do dostępnych danych, pochodzących z Mobilnych Pomiarów Satelitarnych. Porównano wyniki z algorytmami przeznaczonymi dla zastosowań kolejowych. Przeprowadzone analizy wykazały, że przy zastosowaniu proponowanego...
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An algorithm for selecting a machine learning method for predicting nitrous oxide emissions in municipal wastewater treatment plants
PublicationThis study presents an advanced algorithm for selecting machine learning (ML) models for nitrous oxide (N2O) emission prediction in wastewater treatment plants (WWTPs) employing the activated sludge process. The examined ML models comprised multivariate adaptive regression spline (MARS), support vector machines (SVM), and extreme gradient boosting (XGboost). The study explores the concept that involves new criteria to select the...
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Laser-textured cross-hatched surface topography analysis with evaluation of high-frequency measurement noise
PublicationThe precision of surface roughness determination using ISO 25178 parameters relies on various factors that directly impact the measurement process. In industry applications, the contactless roughness measurement reduces data collection time. However, it introduces several potential errors, including those stemming from the environment. One of the main types of errors encountered during topography analysis is measurement noise,...
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The antitumor compound triazoloacridinone C-1305 inhibits FLT3 kinase activity and potentiates apoptosis in mutant FLT3-ITD leukemia cells.
PublicationAim: FMS-like receptor tyrosine kinase (FLT3) is expressed in some normal hematopoietic cell types and plays an important role in the pathogenesis of acute myeloid leukemia (AML). In this study, we examined the effects of triazoloacridinone C-1305, an antitumor compound, on AML cells with different FLT3 status in vitro. Methods: A panel of human leukemic cell lines with different FLT3 status was used, including FLT3 internal tandem...
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Możliwości satelitarnej oceny położenia geometrycznego tramwajowych węzłów rozjazdowych
PublicationW referacie skupiono się na kwestii oceny złożonych układów geometrycznych linii tramwajowych, w rejonach krańcówek, ze szczególnym uwzględnieniem węzłów rozjazdowych. Przedstawiono wyniki ciągłych pomiarów satelitarnych przeprowadzonych w eksploatowanym torze. Omówiono metodykę opracowywania wyników, uwzględniającą specyfikę projektowania rozjazdów tramwajowych. Stwierdzono poprawność geometrycznego ukształtowania badanych układów,...
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Wpływ modernizacji linii kolejowych na poprawę wybranych parametrów techniczno - eksploatacyjnych
PublicationW artykule przedstawiono pojęcie jakości robót inwestycyjnych poszczególnych elementów infrastruktury kolejowej oraz metody jej oceny. Skupiono uwagę na jakości początkowej nawierzchni kolejowej po pracach modernizacyjnych na sieci Polskich Linii Kolejowych. Wskazano błędy oraz najczęstsze problemy techniczne występujące w trakcie trwania robót oraz po ich zakończeniu na poszczególnych etapach odbiorów. Opisano wpływ jakości początkowej...
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Przesył energii elektrycznej - potrzeby,progi i bariery
PublicationW artykule przeanalizowano stan aktualny i kierunki rozwoju krajowego systemu przesy ł owego w kontek ś cie potrzeb gospodarki krajowej. Przedstawiono znaczenie sieci przesy ł owych oraz rol ę operatorów systemu przesy ł owego i systemów dystrybucyjnych w sektorze energetycznym. Oceniono mo ż liwo ś ci rozwoju przy uwzgl ę dnieniu aktualnych prognoz zapotrzebowania na energi ę , wytyczono potencjalne...
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Badania wstępne możliwości oceny stanu powierzchni tocznej szyn za pomocą zjawisk wibroakustycznych
PublicationW artykule przedstawiono wstępną koncepcję możliwości wykorzystania zjawisk wibroa-kustycznych w celu oceny stanu powierzchni tocznych szyn. Scharakteryzowano metodykę, zakres badań oraz wybór punktów lokalizacyjnych. Badania wstępne obejmowały pomiary drgań i hałasu na referencyjnym odcinku toru oraz na odcinku toru z wadą squat. Pomiary przeprowadzono na dwóch liniach kolejowych nr 213 Reda – Hel oraz 131 Chorzów Batory – Tczew....
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Application 2D Descriptors and Artificial Neural Networks for Beta-Glucosidase Inhibitors Screening
PublicationBeta-glucosidase inhibitors play important medical and biological roles. In this study, simple two-variable artificial neural network (ANN) classification models were developed for beta-glucosidase inhibitors screening. All bioassay data were obtained from the ChEMBL database. The classifiers were generated using 2D molecular descriptors and the data miner tool available in the STATISTICA package (STATISTICA Automated Neural...
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High-temperature Co-electrolysis of CO2/H2O and direct methanation over Co-impregnated SOEC. Bimetallic synergy between Co and Ni
PublicationTo study the synergy between the transition metals for enhancing the electrochemical and chemical activity, a series of SOECs were modified with a small amount of Co ions, namely 1.8, 3.6, and 5.4 wt% in the reduced state. The addition of βCD into the precursor solution allowed for extremely fine dispersion of Co species across the Ni-YSZ cermet structure. The sample containing 3.6 wt% Co reached an outstanding over 2.5-times-higher...
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Novel Complementary Resonator for Dielectric Characterization of Substrates Based on Permittivity and Thickness
PublicationThis paper presents a novel complementary resonator featuring high sensitivity, low fabrication cost, and improved performance. The proposed structure consists of a complementary concentric square and circular ring resonator (CCSCRR) with multiple splits to enhance the inductance of the resonator. The proposed CCSCRR is coupled to a microstrip transmission line with an impedance of fifty ohms to create a high-sensitivity sensor....
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Controlling crystallites orientation and facet exposure for enhanced electrochemical properties of polycrystalline MoO3 films
PublicationThis study focuses on the development and optimization of MoO3 films on commercially available FTO substrates using the pulsed laser deposition (PLD) technique. By carefully selecting deposition conditions and implementing post-treatment procedures, precise control over crystallite orientation relative to the substrate is achieved. Deposition at 450 °C in O2 atmosphere results in random crystallite arrangement, while introducing...
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Fabrication of anti-corrosion nitrogen doped graphene oxide coatings by electrophoretic deposition
PublicationThis work assesses anti-corrosion properties of graphene and N-doped graphene coatings deposited on copper by an electrophoretic method. Graphene oxide (GO) precursor was synthesized by an improved Hummers' method, whereas N-doping was performed hydrothermally in the presence of ammonia. After nitrogenation, doped graphene oxide samples (NGO) contained a reduced amount of oxygen and about 9% w/w nitrogen as pyridinic, pyrrole,...
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Infrared techniques for natural convection investigations in channels between two vertical, parallel, isothermal and symmetrically heated plates
PublicationThe effect of the gap width between two symmetrically heated vertical, parallel, isothermal plates on intensity of natural convective heat transfer in a gas (Pr = 0.71) was experimentally studied using the balance and gradient methods. In the former method heat fluxes were determined based on measurements of the voltage and electric current supplying the heaters placed inside the walls. In the latter, heat fluxes were calculated...
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Comparison of the paracetamol electrochemical determination using boron-doped diamond electrode and boron-doped carbon nanowalls
PublicationTwo different type of electrodes, boron-doped diamond electrode (BDD) and boron-doped carbon nanowalls (B:CNW) electrode, were used for the electrochemical determination of paracetamol using the cyclic voltammetry and the differential pulse voltammetry in phosphate buffered saline, pH = 7.0. The main advantage of these electrodes is their utilization without any additional modification of the electrode surface. The peak current...
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Rapid ion-exchange matrix removal for a decrease of detection limits in the analysis of salt-rich reservoir waters for fluorobenzoic acids by liquid chromatography coupled with tandem mass spectrometry
PublicationA matrix removal procedure with ion-exchange resin prior to analysis for 18 fluorinated benzoic acids (FBAs) tracers in saline (>25% salt) reservoir water was optimized. The elimination of >98% of salt and the simultaneous matrix sample cleanup allowed the direct analysis using the supernatant by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). This resulted in a gain in detection limits for most of the tracers...
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Effect of interconnect coating procedure on solid oxide fuel cell performance
PublicationChromium (Cr) species vaporizing from chromia-forming alloy interconnects is known as a source of degradation in solid oxide fuel cell (SOFC) stacks called “cathode poisoning”. (Mn,Co)3O4 spinel coatings offer good protection against Cr evaporation during operation. In this study, Crofer 22 APU steel interconnects were electrophoretically deposited in different mediums to obtain high packing of green coating layer. The optimized...
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Artificial Intelligence in the Diagnosis of Onychomycosis—Literature Review
PublicationOnychomycosis is a common fungal nail infection that is difficult to diagnose due to its similarity to other nail conditions. Accurate identification is essential for effective treatment. The current gold standard methods include microscopic examination with potassium hydroxide, fungal cultures, and Periodic acid-Schiff biopsy staining. These conventional techniques, however, suffer from high turnover times, variable sensitivity,...