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Wyniki wyszukiwania dla: IN%20VITRO%20BIODEGRADATION
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In vitro biodegradation of bacterial nanocellulose under conditions simulating human plasma in the presence of selected pathogenic microorganisms
PublikacjaThe Biodegradability of bacterial nanocellulose (BNC) was assessed based on a change in its properties under conditions simulating human plasma in the presence or absence of the pathogens Staphylococcus aureus, Candida albicans and Aspergillus fumigatus. It was shown that the dry mass of BNC did not change during 6 months of incubation, except for samples stored in the presence of moulds, where the dry mass reduced by 40 %. The...
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TOXICOLOGY IN VITRO
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BIODEGRADATION
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Journal of Bioremediation & Biodegradation
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Biodegradation of organic compounds by activated sludge
PublikacjaBadano biodegradalność pestycydów zawartych w ściekach z zakładów syntezy organicznej przez osad czynny z oczyszczalni komunalnej i przemysłowej. Zbadano również odporność mikroorganizmów osadu czynnego na syntetyczne związki organiczne zawarte w ściekach farmaceutycznych. W trakcie badań prowadzona była kontrola mikroskopowa osadu czynnego. Badania prowadzone były na modelu laboratoryjnym oczyszczalni ścieków. Największą odporność...
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Environmental risk, toxicity, and biodegradation of polyethylene: a review
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Biodegradation and sorption of nodularin (NOD) in fine-grained sediments
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Biodegradation of nodularin and other nonribosomal peptides by the Baltic bacteria
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Influence of ozonation and biodegradation on toxicity of industrial textile wastewater
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Biodegradation of modified poly(î-caprolactone) in different environments
PublikacjaPorównano odporność na biodegradację różnych filmów poliepsilon kaprolaktonu w wodzie morskiej z Bałtyku, w roztworze soli, w wodzie morskiej z azydkiem sodu oraz w kompoście z osadem czynnym. Oceniano zmiany ubytku wagi, lepkość właściwości wytrzymałościowe, stopień krystaliczności i morfologię przed i po procesie degradacji. Filmy z dodatkiem środków antypoślizgowych, degradowane w środowiskach naturalnych ulegały rozkładowi...
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A Rapid and Simple Method for Screening Microorganisms with a Potential for Catechol Biodegradation
PublikacjaCatechol is a highly toxic compound that is also a key intermediate in biodegradation pathways of various aromatic compounds. In this paper, a new screening method for isolation of microorganisms with the potential for catechol biodegradation is reported. The method described is based on the ability of catechol to form a color complex with Fe3+ ions. For this purpose, basal medium that is widely used for classification of microorganisms...
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Photodegradation and biodegradation study of benzo(a)pyrene in different liquid media.
PublikacjaPrzedstawiono wyniki badań dotyczące degradacji benzo(a)pirenu w różnych mediach ciekłych (woda, rozpuszczalniki organiczne). Zbadano wpływ różnych czynników : temperatura, czas przechowywania próbki, dostęp światła, obecność naturalnie występujących mikroorganizmów, na przebieg procesów degradacji benzo(a)pirenu. Degradacja w rozpuszczalnikach organicznych przebiega następująco: dichlorometan > acetonitryl >heksan > cykloheksan...
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Nitrofurazone Removal from Water Enhanced by Coupling Photocatalysis and Biodegradation
Publikacja(1) Background: Environmental contamination with antibiotics is particularly serious because the usual methods used in wastewater treatment plants turn out to be insufficient or ineffective. An interesting idea is to support natural biodegradation processes with physicochemical methods as well as with bioaugmentation with efficient microbial degraders. Hence, the aim of our study is evaluation of the effectiveness of different...
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Effect of transglutaminase and EDC on biodegradation of fish gelatin and gelatin-chitosan films
PublikacjaCelem pracy było zbadanie podatności usieciowanych folii opakowaniowych z naturalnych polimerów na enzymatyczną hydrolizę. Niemodyfikowane folie żelatynowe były całkowicie hydrolizowane przez pepsynę i proteinazę N oraz w 60% przez pepsynę. Sieciowania przy użyciu transglutaminazy lub EDC zmiejszyło podatność folii na hydrolizę tylko przez pepsynę. Obecność chitozanu w dwuskładnikowych foliach modyfkownych EDC zmniejszyła stopień...
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Mathematical Modeling of Dissolved Matter Transport with Biodegradation in Activated-Sludge Systems
PublikacjaW pracy przedstawiono problem matematycznego modelowania transportu substancji rozpuszczonej z biodegradacją w systemach z osadem czynnym. Przedstawione zostały główne równania opisujące proces transportu adwekcyjno-dyspersyjnego wraz z modelem biokinetycznym ASM2d, opisującym procesy przemian pod wpływem osadu czynnego. W artykule przedstawiono wyniki symulacji numerycznych odtwarzających testy laboratoryjne przeprowadzone w nieprzepływowych...
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Biodegradation of nodularin and effects of the toxin on bacterial isolates from the Gulf of Gdańsk
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Screening of Microorganisms for Biodegradation of Simazine Pollution (Obsolete Pesticide Azotop 50 WP)
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Study of thermal property changes of biopol/polyamide 11 blends during biodegradation in compost
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Study of thermal property changes of biopol/polyamide 11 blends during biodegradation in compost.
PublikacjaPrzeprowadzone badania dotyczą zmian struktury krystalicznej podczas biodegradacji mieszanin polimerowych z udziałem PHBV, gdzie zależność między strukturą a podatnością na biodegradację związane są nie tylko ze stopniem krystaliczności PHBV ale także z budową faz składników mieszaniny. Wyniki pozwalają stwierdzić, że mieszaniny PA11/PHBV zawierające 60% kopoliestru PHBV(otrzymane przy użyciu wytłaczarki dwuślimakowej) charakteryzują...
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The importance of degradation in the fate of selected organic compounds in the environment. Part II. Photodegradation and biodegradation
PublikacjaDegradacja jest naturalnym, wszechobecnym procesem rozkładu substancji organicznych obecnych w środowisku. Produkty degradacji lub pośrednie produkty rozkładu związków organicznych często wykazują inną toksyczność w stosunku do mikroorganizmów, zwierząt i ludzi niż związki wyjściowe. Procesy fotodegradacji i biodegradacji zachodzą zwykle jednocześnie. Fotodegradacja uznawana jest za wstępny proces, po którym następuje rozkład...
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Influence of microbial adaptation and supplementation of nutrients on the biodegradation of ionic liquids in sewage sludge treatment processes
PublikacjaCiecze jonowe przyciągają coraz większą uwagę ze strony przemysłu, ze względu na możliwość zastosowania ich jako zamiennik dla bardziej niebezpiecznych substancji. Jednakże część ich struktury może stać się trwałym zanieczyszczeniem dlatego niezbędne jest prowadzenie badań w celu określenia zagrożenia dla środowiska, związanego z obecnością w nim cieczy jonowych, np. dotyczących możliwości ich biodegradacji w warunkach rzeczywistych....
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Study on a polish peat bog “Rucianka” as a source of yeast strains capable of effective phenol biodegradation
PublikacjaPhenol is one of the most widely distributed environmental pollutants which can be found in wastewaters and industrial effluents. Due to its toxicity and resistance to self-degradation, it could become even lethal for humans and animals. The treatment of this toxic compound is focused on psychical–chemical methods, although biological treatment of phenol is preferable for economic aspects related to relatively...
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1-Methyl-3-octylimidazolium Chloride − Sorption and Primary Biodegradation Analysis in Activated Sewage Sludge
PublikacjaCiecze jonowe są nielotne i z tego względu nie przedostają się do atmosfery, jednakże mogą zanieczyszczać wodę i gleby. Badania sposobów redukcji stężenia cieczy jonowych w środowisku jest istotne ze względu na rosnące zapotrzebowanie na biodegradowalne związki chemiczne. Ustalono, że górny limit stężeń dla pierwotnej biodegradacji chlorku 1-metylo-3-oktyloimidazolu wynosi 0.2 mM. Powyżej tego stężenia aktywność dehydrogenaz znacząco...
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Applied In Vitro Toxicology
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Fungal co-culture improves the biodegradation of hydrophobic VOCs gas mixtures in conventional biofilters and biotrickling filters
PublikacjaThe present study systematically evaluated the potential of Candida subhashii, Fusarium solani and their consortium for the abatement of n-hexane, trichloroethylene (TCE), toluene and α-pinene in biofilters (BFs) and biotrickling filters (BTFs). Three 3.2 L BFs packed with polyurethane foam and operated at a gas residence time of 77 s with an air mixture of hydrophobic volatile organic compounds (VOCs) were inoculated with C. subhashii,...
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Bacterial consortium an axenic cultures isolated from activated sewage sludge for biodegradation of imidazolium-based ionic liquid
PublikacjaExtensive research and increasing number of potential industrial applications made ionic liquids (ILs) important materials in design of new, cleaner technologies. Together with the technological applicability, the environmental fate of these chemicals is considered and significant efforts are being made in designing strategies to mitigate their potential negative impacts. Many ILs are proven to be poorly biodegradable and relatively...
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The impact of thermomechanical and chemical treatment of waste Brewers’ spent grain and soil biodegradation of sustainable Mater-Bi-Based biocomposites
PublikacjaDue to the massive plastic pollution, development of sustainable and biodegradable polymer materials is crucial to reduce environmental burdens and support climate neutrality. Application of lignocellulosic wastes as fillers for polymer composites was broadly reported, but analysis of biodegradation behavior of resulting biocomposites was rarely examined. Herein, sustainable Mater-Bi-based biocomposites filled with thermomechanically-...
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Insights into Seawater Biodegradation of Sustainable Mater-Bi/Poly(ε-caprolactone)-Based Biocomposites Filled with Diisocyanate-Modified Cellulose Particles
Publikacja: Due to rapid economic growth, the use of plastics in almost all areas of human life has significantly increased over recent decades, leading to massive pollution. Therefore, works dealing with sustainable and biodegradable polymer materials are vital now. Herein, sustainable MaterBi/poly(ε-caprolactone) (PCL)-based biocomposites, filled with diisocyanate-modified cellulose particles, were prepared and subjected to 12-week seawater...
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INTERNATIONAL BIODETERIORATION & BIODEGRADATION
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IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
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Kinetics of hexane and cyclohexane biodegradation using Candida subhashii in mineral salt medium in the presence of DES solution
Dane BadawczeDataset presents results of investigations on kinetics of biodegradation of hexane and cyclohexane in Candida subhashii.
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Toxicity of ionic liquid cations and anions towards activated sewage sludge organisms from different sources – Consequences for biodegradation testing and wastewater treatment plant operation
PublikacjaIonic liquids (ILs) have attracted great interest in academia and industry during the last decade. So far, several ILs have been used in technological processes, from small scale to industrial applications, which makes it more and more likely that they will be released into the environment. Researches have been actively studying the environmental and toxicological bevaviour of ILs, but their influence on the activated sewage sludge...
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Determination of phenol biodegradation pathways in three psychrotolerant yeasts, Candida subhashii A011, Candida oregonensis B021 and Schizoblastosporion starkeyi-henricii L012, isolated from Rucianka peatland
PublikacjaIn this study, three psychrotolerant phenol-degrading yeast strains Candida subhashii (strain A011), Candida oregonenis (strain B021) and Schizoblastosporion starkeyi-henricii (strain L012) isolated from Rucianka peatland were examined to determine which alternative metabolic pathway for phenol biodegradation is used by these microorganisms. All yeast strains were cultivated in minimal salt medium supplemented with phenol at 500,...
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Badania in vivo i in vitro
WydarzeniaTrzecie spotkanie w ramach cyklu Badania in vivo i in vitro oczami zespołu V i IX w POB 3 – cykl spotkań o współpracach wewnątrz- i międzyuczelnianych, organizowanego w Gdańskim Uniwersytecie Medycznym.
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Correlation between in vitro and in vivo data on food digestion. What can we predict with static in vitro digestion models?
PublikacjaDuring the last decade, there has been a growing interest in understanding food's digestive fate in order to strengthen the possible effects of food on human health. Ideally, food digestion should be studied in vivo on humans but this is not always ethically and financially possible. Therefore, simple in vitro digestion models mimicking the gastrointestinal tract have been proposed as alternatives to in vivo experiments. Thus,...
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Comparative in vitro research of the Human Aortic Bioprosthesis
PublikacjaE valuate of the usefulness and reliability of structures based on the analysis of recorded parameters determining the flow through the Human Aortic Bioprosthesis (HAB) have been dealt with. By flow parameters changes determining the performance environment of prosthesis analyzed change of the motion dynamics of the valve leaflets as a function of pressure, thereby determining the degree of alignment of the prosthesis to the performance...
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In vitro toxicity studies of biodegradable, polyelectrolyte nanocapsules
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In vitro screening of 65 mycotoxins for insecticidal potential
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In Vitro Dissolution of Na-Ca-P-Oxynitrides
Publikacja: Sodium-calcium-phosphate based oxynitride glasses and glass-ceramics doped with Mg, Si, and Nb were studied in vitro in simulated body fluid (SBF) under static conditions. The release of ions and pH changes up to 7 days of immersion were investigated. The nitrogen incorporation into phosphate glass matrix was found to notably influence in vitro dissolution only of homogenous glasses. Increasing the nitrogen content in the samples...
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Degradation of implantable materials – in vivo and in vitro research
PublikacjaThe article concerns the biological and electrochemical degradation of metallic implants in vivo and in vitro studies. The in vivo research dealt with degradation of plates used to join bones, as well as endoprostheses. The most common damages were: metalosis, breaking in the microstructure changes, breaking in area of holes, as well as plastic deformation throughout the length of an implant. The material used for the research...
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Modified polycarbonate urethane: synthesis, properties and biological investigation in vitro
PublikacjaNowy poliweglano uretan (PCU-I) otrzymano z alifatycznych monomerów: poliwęglanu heksanodiolu, 4,4'diizocyjanianu dicykloheksanometanu, mieszaniny małocząsteczkowych dioli i oleju rycynowego (zawierającego głównie trigliceryd kwasu 12-hydroksyoleinowego). PCU-II otrzymano analogicznie ale bez udziału oleju rycynowego. Obydwa PCU charakteryzowały się dobrą wytrzymałością na rozciąganie. PCU-I miał niższą temperaturę zeszklenia a...
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In vitro evaluation of novel lipopeptides with potential therapeutic application
PublikacjaThe synthesis of derivatives of Gly-His-Lys was elaborated followed by their antimicrobial activity investigation.
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In Vitro Measurement of Conformational Stability of Fibrinogen Adsorbed on Siloxane
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In-vitro controlled release of doxorubicin from silica xerogels
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Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations
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Potential applications of plant in vitro cultures in phytoremediation studies
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The effectiveness of chemotherapy and electrochemotherapy on ovarian cell lines in vitro
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Bile conjugation and its effect on in vitro lipolysis of emulsions
PublikacjaBile Salts (BS) are responsible for stimulating lipid digestion in our organism. Gut microbiota are responsible for the deconjugation process of primary conjugated to secondary unconjugated BS. We use two structurally distinct BS and characterize the rate of lipolysis as a compound parameter. A static in-vitro digestion model as well as meta-analysis of literature data has been performed to determine the most influential factors...
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Nanocrystallization as a tool for controlling in vitro dissolution of borophosphate glass
PublikacjaThe controlled nanocrystallization of sodium-calcium-borophosphate glass (Na16.6Ca5.1B10.5Al0.8P10.5 O56.5 in at %) was conducted to investigate its influence on in vitro dissolution. Three temperatures (570 ◦C, 590 ◦C, and 610 ◦C) were selected based on thermal analysis and investigation of the morphology, structure, and in vitro dissolution of glass and glass-ceramics was conducted. The results of X-ray diffraction confirmed...
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INFOGEST static in vitro simulation of gastrointestinal food digestion
PublikacjaDeveloping a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestinal tract. These simulations have used a wide range of different conditions that often have very little physiological relevance, and this impedes the meaningful comparison of results. The standardized protocol presented here is based on an international consensus...
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Antibacterial activity of the secondary metabolites from in vitro cultures of Drosera aliciae
PublikacjaRośliny owadożerne (D. aliciae) metabolity wtórne farmakologicznie czynne substancje. Na wzrost akumulacji tychże substancji w tkankach roślin owadożernych ma wpływ dodatek elicytora. Końcowego oznaczenia zawartości metabolitów w ekstraktach roślinnych dokonano techniką chromatografii cieczowej.
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Systemy ekspresyjne białek cytochromu P450 w badaniach in vitro metabolizmu leków = Expression systems of cytochrome P450 proteins in studies of drug metabolism in vitro
PublikacjaBiałka cytochromu P450 to najważniejsze enzymy biorące udział w metabolizmie większości stosowanych w klinice leków, odpowiedzialne za ich aktywację lub detoksykację. Niektóre z dróg metabolizmu leku mogą być jednak odpowiedzialne za jego podwyższoną toksyczność. Nowe systemy ekspresyjne białek cytochromu P450 w komórkach ssaków, w tym człowieka, projektowane są w celu poznania roli metabolizmu w mechanizmie działania potencjalnych,...
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Cytotoxicity of doxorubicin conjugated with C60 fullerene. Structural and in vitro studies
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New Chalcones Derivatives With Potent Antitumor Activity And Their Metabolism In Vitro
PublikacjaChalcone derivatives exhibit a broad range of biological activities, with antioxidant and cytotoxic properties among the most studied. Despite numerous reports on chalcones as cytotoxic, and potentially anticancer agents, very little is know on their actual mechanism of activity. Generally, chalcones are considered as antimitotic agents, which interfere with tubulin assembly.We have recently developed a new class of chalcones with...
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Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study
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Calophyllum inophyllum in vaginitis treatment: Stimulated by electroporation with an in vitro approach
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The in vitro culture supplements and selected aspects of canine oocytes maturation
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In Vitro Study of a Stentless Aortic Bioprosthesis Made of Bacterial Cellulose
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Analysis of the Factors Affecting Static In Vitro Pepsinolysis of Food Proteins
PublikacjaIn this meta-analysis, we collected 58 publications spanning the last seven decades that reported static in vitro protein gastric digestion results. A number of descriptors of the pepsinolysis process were extracted, including protein type; pepsin activity and concentration; protein concentration; pH; additives; protein form (e.g., ‘native’, ‘emulsion’, ‘gel’, etc.); molecular weight of the protein; treatment; temperature; and...
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Nanoparticles Influence Lytic Phage T4-like Performance In Vitro
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Detection of dental lessions by means of immittance measurements - an in vitro study
PublikacjaW pracy przedstawiono stanowisko do badań in vitro przewodności tkanek zęba.
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In vitro and in silico assessment of anti-inflammatory activity of cocoa powders
PublikacjaPlants are considered the major sources of biologically active compounds, which provide unlimited opportunities for their use either as medical treatments or as novel drug formulations. Cocoa powder is frequently used in nutrition and is known to have many benefits thanks to its wide range of biological activities. The presented study was focused on th evaluation of the anti-inflammatory potential of extracts obtained from cocoa...
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Acclimation of denitrifying activated sludge to a single vs. complex external carbon source during a start-up of sequencing batch reactors treating ammonium-rich anaerobic sludge digester liquors
PublikacjaIn this study, denitrification of ammonium- reach anaerobic sludge digester liquor was investigated during start-up periods of two laboratory- scale ‘‘fill-and-draw’’ reactors. One reactor was fed with a single carbon source (ethanol), whereas the other reactor was fed with a complex carbon source (fusel oil). During two acclimation experiments, the structure of microbial community involved in denitrification was analyzed using...
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In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine
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In vitro antioxidative and binding properties of phenolics in traditional, citrus and exotic fruits
PublikacjaMany polyphenols bind proteins, therefore our research was focused on the potential of protein binding to polyphenols of investigated fruits and their health-related effects. The contents of polyphenols and related antioxidant activities of traditional, citrus and exotic fruits were compared. The presence of polyphenols (flavonoids and phenolic acids) in the investigated samples and their interaction with human serum albumin (HSA)...
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Formulation, characterisation and in vitro studies of doxorubicin-loaded silica–polydimethylsiloxane granules
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Synthesis and in vitro characterization of freeze-dried doxorubicin-loaded silica xerogels
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Metody oznaczania in vitro właściwości przeciwutleniających próbek żywności. Cz. I
PublikacjaWystępowanie większości chorób cywilizacyjnych może być rezultatem stresu oksydacyjnego prowadzącego do różnorodnych zmian w ludzkim organizmie, wywołanych działaniem tzw. reaktywnych form tlenu. Z tego też powodu pojawiło się olbrzymie zapotrzebowanie na szybkie testy umożliwiające pomiar całkowitej zawartości przeciwutleniaczy czy też ogólnej siły przeciwutleniającej produktów żywnościowych a w szczególności świeżych warzyw...
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Agomelatine's antiglycoxidative action—In vitro and in silico research and systematic literature review
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Biodegradable macromolecular conjugates of citropin: Synthesis, characterization and in vitro efficiency study
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Protective effect of desloratadine against oxidative stress in human erythrocytes in vitro
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The differentiation and transdifferentiation of epithelial cells in vitro – is it a new strategy in regenerative biomedicine?
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In Vitro Toxicological Screening of Stable and Senescing Cultures of Aphanizomenon, Planktothrix, and Raphidiopsis
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Titania Nanofiber Scaffolds with Enhanced Biointegration Activity—Preliminary In Vitro Studies
PublikacjaThe increasing need for novel bone replacement materials has been driving numerous studies on modifying their surface to stimulate osteogenic cells expansion and to accelerate bone tissue regeneration. The goal of the presented study was to optimize the production of titania-based bioactive materials with high porosity and defined nanostructure, which supports the cell viability and growth. We have chosen to our experiments TiO2...
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Size-Dependent in Vitro Biocompatibility and Uptake Process of Polymeric Carbon Nitride
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A standardised static in vitro digestion method suitable for food – an international consensus
PublikacjaSimulated gastro-intestinal digestion is widely employed in many fields of food and nutritional sciences, as conducting human trials are often costly, resource intensive, and ethically disputable. As a consequence, in vitro alternatives that determine endpoints such as the bioaccessibility of nutrients and non-nutrients or the digestibility of macronutrients (e.g. lipids, proteins and carbohydrates) are used for screening and building...
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Biological and mechanical properties of bone cement with nanoarticles - in vitro and in vivo research
PublikacjaDespite antibiotic preventive treatment both before and after implant implementation, the risks of infection are real. These infections develop at the implant surface a few months after inserting them into the body. To prevent the development of bacteria and reduce the risk of infection, implants coated with nanoparticles are used. The Mechanical Department of the Technical University of Gdansk carries out research into using bone...
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In Vitro Biological Characterization of Silver-Doped Anodic Oxide Coating on Titanium
PublikacjaDespite the high biocompatibility and clinical effectiveness of Ti-based implants, surface functionalization (with complex osteointegrative/antibacterial strategies) is still required. To enhance the dental implant surface and to provide additional osteoinductive and antibacterial properties, plasma electrolytic oxidation of a pure Ti was performed using a nitrilotriacetic acid (NTA)-based Ag nanoparticles (AgNP)-loaded calcium–phosphate...
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Biological and mechanical properties of bone cement with nanoparticles - in vivo and in vitro research
PublikacjaDespite antibiotics preventive treatment, before and after an implant implementation, risk of infection are real. These infections at the implant surface develop in a few months after applying them into the body. To prevent the development of bacteria and to reduce the risk of infection, implants coated with nanoparticles come into use. The Mechanical Department of the Technical University of Gdańsk carried out a research with...
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In vitro studies of polyphenols, antioxidants and other dietary indices in kiwifruit (Actinidia deliciosa)
PublikacjaOpisano wyniki badań poziomu protein oraz potencjału przeciwutleniającego w próbkach owoców kiwi, przechowywanych i dojrzewających w atmosferze etylenu ( w ciągu pierwszych 10 dni). Próbki owoców kiwi podzielono (w sposób przypadkowy) na dwie grupy:-próbki nie poddawane obróbce,-próbki poddawane obróbce (dojrzewanie w atmosferze etylenu).W próbkach oznaczano między innymi: wolne cukry, proteiny, polifenole oraz zdolność przeciwutleniającą....
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Preparation and in vitro characterisation of bioactive mesoporous silica microparticles for drug delivery applications
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Synthesis and in vitro characterization of freeze-dried doxorubicin-loaded silica/PEG composite
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Polyphenol-Enriched Composite Bone Regeneration Materials: A Systematic Review of In Vitro Studies
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Cinnamon powder: an in vitro and in vivo evaluation of antifungal and plant growth promoting activity
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Anticancer properties of low molecular weight oat beta-glucan – An in vitro study
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Edible Flowers Extracts as a Source of Bioactive Compounds with Antioxidant Properties—In Vitro Studies
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Parallel in vitro and in silico investigations into anti-inflammatory effects of non-prenylated stilbenoids
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In vivo and in vitro study of a novel nanohydroxyapatite sonocoated scaffolds for enhanced bone regeneration
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The effect of electromagnetic field on reactive oxygen species production in human neutrophilsin vitro
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Transcriptional activity of epigenetic remodeling genes declines in keratinocytes after in vitro expansion
PublikacjaPURPOSE: In vitro expansion is an invaluable method to obtain keratinocytes in amounts necessary for effective transplantation therapies. In vitro cell culturing provokes questions concerning potential epigenetic alterations occurring in expanded cells in the context of usefulness for transplantation and safety. The purpose of this study was to investigate as to whether keratinocyte expansion is associated with changes in the activity...
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Specificity of Infant Digestive Conditions: Some Clues for Developing Relevant In Vitro Models
PublikacjaDigestion of nutrients is an essential function of the newborn infant gut to allow growth and development and understanding infant digestive function is essential to optimize nutrition and oral drug delivery. Ethical considerations prohibit invasive in vivo trials and as a consequence in vitro assays are often conducted. However, the choice of in vitro model parameters are not supported by an exhaustive analysis of the literature...
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Butyrylcholinesterase signal sequence self-aggregates and enhances amyloid fibril formation in vitro
PublikacjaAlzheimer’s disease (AD) pathogenesis has been attributed to extracellular aggregates of amyloid β (Aβ) plaques and neurofibrillary tangles in the human brain. It has been reported that butyrylcholinesterase (BChE) also accumulates in the brain Aβ plaques in AD. We have previously found that the BChE substitution in 5′UTR caused an in-frame N-terminal extension of 41 amino acids of the BChE signal peptide. The resultant variant...
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PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke
PublikacjaIschemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the pro-viable activity of cell-penetrating peptides: arginine-rich Tat(49–57)-NH2 (R49KKRRQRRR57-amide) and its less basic analogue, PTD4 (Y47ARAAARQARA57-amide). Our model included glucose...
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The bioactivity of processed garlic (Allium sativum L.) as shown in vitro and in vivo studies on rats
PublikacjaCzosnek w trakcie procesu obróbki traci znaczną część swojej bioaktywności. Właściwości przeciwutleniające zmierzone metodą FRAP i DPPH stwierdzono na najwyższym poziomie w przypadku czosnku surowego oraz po krótkim okresie gotowania. Badania na szczurach poddanych diecie z dodatkiem krótkogotowanego czosnku potwierdziły, że proces ten nie zaburza właściwości przeciwutleniających surowego czosnku. U zwierząt stwierdzono poprawę...
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Bioactive peptides from beef products fermented by acid whey – in vitro and in silico study
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In vitro photodynamic activity of lipid vesicles with zinc phthalocyanine derivative against Enterococcus faecalis
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Characterization of In Vitro and In Vivo Metabolism of Antazoline Using Liquid Chromatography-Tandem Mass Spectrometry
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Degradibility in vitro of polyurethanes based on synthetic atactic poly[)R,S)-3-hydroxybutyrate
PublikacjaThe aim of the paper was to determine the degradibility of aliphatic polyurethanes in hydrolytic and oxidative solutions. DSC, GPC, density, polymer surface morphology were studied.
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Bioactive silica-based drug delivery systems containing doxorubicin hydrochloride: In vitro studies
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Antimicrobial photodynamic therapy with fulleropyrrolidine: photoinactivation mechanism of Staphylococcus aureus, in vitro and in vivo studies
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