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Search results for: drug delivery devices
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Wpływ produkcji butelek z tworzyw sztucznych na środowisko naturalne. Cz. I. Zastosowanie metody oceny ReCiPe 2016 w celu identyfikacji problemów środowiskowych
PublicationDokonano oceny wpływu opakowań na środowisko naturalne. Głównym celem było przeprowadzenie analizy cyklu życia (LCA) butelki do napojów wykonanej z poli(tereftalanu etylenu) (PET). Za jednostkę funkcjonalną przyjęto łącznie 1000 szt. butelek PET o pojemności 1 L. Granica przyjętego systemu obejmowała kroki od momentu dostarczenia preform do zakładu produkcyjnego aż do ich prawidłowego ukształtowania w procesie produkcyjnym. Z systemu...
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Opracowanie i wprowadzenie nowoczesnego systemu utrzymania ruchu urządzeń opartego na strategii planowo – zapobiegawczej na obiekcie offshore
PublicationW pracy przedstawiono metodykę utrzymania ruchu maszyn i urządzeń na obiekcie offshore. Opracowany autorski system utrzymania ruchu, który został wdrożony na morskiej platformie wydobywczej „Petrobaltic” gdzie do przesyłu i przetwarzania danych wykorzystano dostępną infrastrukturę informatyczną. Założenia realizowano z wykorzystaniem metod naukowych takich jak analiza case study, metody eksperckie i inne. Pracę zrealizowano w ośmiu...
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Możliwości zastosowania zasobnikowych jednostek trakcyjnych na liniach kolejowych na przykładzie Pomorskiej Kolei Metropolitalnej
PublicationW artykule zwrócono uwagę, że zasobniki stosowane głównie do rekuperacji energii, mogą być również wykorzystane do zasilania pociągów na niezelektryfikowanych i zelektryfikowanych odcinkach linii kolejowych. Innowacyjność tego rozwiązania wykazano na podstawie dwóch aplikacji kolejowych elektrycznych zasobnikowych jednostek trakcyjnych: pierwszej funkcjonującej od 2014 roku na linii Utsunomiya – Karasuyama w Japonii oraz drugiej,...
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Impact of inorganic ions and pH variations on toxicity and endocrine potential of selected environmentally relevant pharmaceuticals
PublicationAssessment of the impact of pharmaceutical residues on living organisms is a very complex subject. Apart from taking into account the toxicity of individual compounds, environmental factors should also be taken into account. In this paper, attempts were made to assess the impact of coexisting inorganic ions and changes in pH on the toxicity of ten selected pharmaceuticals. Two bioassays were used to measure the estrogenic and androgenic...
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Metabolism of antitumour agent 1-nitroacridine derivative, C-1748 in pancreatic cancer cell lines
PublicationPancreatic cancer has the highest mortality rate of all major cancers because of limited treatment options. Surgical removal of the tumour is possible only in its early stage, nevertheless the asymptomatic development very often makes unable an accurate diagnose. In the case of metastatic pancreatic cancer only chemotherapy, mainly with gemcitabine, can be offered to patients. However, common resistance towards gemcitabine imposes...
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Badanie wybranych właściwości wyłączników różnicowoprądowych typu F
PublicationW instalacjach elektrycznych niskiego napięcia instaluje się coraz więcej przekształtników energoelektronicznych (systemy fotowoltaiczne, instalacje ładowania pojazdów elektrycznych, układy napędowe o regulowanej prędkości obrotowej silnika), a mają one wpływ na dobór typu wyzwalania wyłączników różnicowoprądowych (AC, A, F lub B). W obwodach, w których pojawia się prąd różnicowy zawierający składowe o częstotliwości innej niż...
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Antiferromagnetic Order in the Rare-Earth Halide Perovskites CsEuBr3 and CsEuCl3
PublicationBulk CsEuBr3 and CsEuCl3 are experimentally shown to be magnetic semiconductors that order antiferromagnetically at Néel temperatures of 2.0 K and 1.0 K, respectively. Given that nanoparticles and thin films of CsEuCl3 have been reported to order ferromagnetically at a similar temperature, our observation of antiferromagnetic ordering in CsEuBr3 and CsEuCl3 expands the possible applications of halide perovskites to now include...
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Improving the production planning and control process
PublicationFocusing the activities of a production business on the strategy based on quality entails orientation on meeting the expectations of the customers with respect to the product itself, and the terms of its delivery. The article notes the role of the production planning and control process in improving the quality of the business offer. It identifies the objectives set for the process from the perspective of meeting the expectations...
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PROJECT IMPLEMENTATION IN ORGANISATIONS OF REPETITIVE ACTIVITIES
PublicationThe study presents the implementation of projects in organisations that achieve business objec-tives through the implementation of repetitive actions. Projects in these organisations are, on the one hand, treated as marginal activities, while the results of these projects have significant impact on the delivery of main processes, e.g. through the introduction of new products. Human capital and solutions in this field bear impact...
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Voltage control in a power system with renewable sources of energy
PublicationIntensive development of distributed generation in power systems, caused by the European Union energy policy, gives possibility for improving safety in power delivery as well as optimizing the costs of the systems functioning. In this context, distributed generation can be used for voltage control in power systems – it can be performed by the control of reactive power of each source of energy or a group of energy sources. This...
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Detection of propofol concentrations in blood by Raman spectroscopy
PublicationIn this paper we present a proof-of-concept of a Raman spectroscopy-based approach for measuring the content of propofol, a common anesthesia drug, in whole human blood, and plasma, which is intended for use during clinical procedures. This method utilizes the Raman spectroscopy as a chemically–sensitive method for qualitative detection of the presence of a drug and a quantitative determination of its concentration. A number of...
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Utilizing Morphological and Physiological Parameters of Lemna minor for Assessing Tetracyclines’ Removal
PublicationAntibiotics with significant environmental toxicity, e.g., tetracyclines (TCs), are often used in large quantities worldwide, with 50–80% of the applied dose ending up in the environment. This study aimed to investigate the effects of exposure to tetracycline hydrochloride (TC) and minocycline hydrochloride (MIN) on L. minor. Our research evaluated the phytotoxicity of the TCs by analyzing plant growth and biomass and evaluating...
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Optimum Choice of Randomly Oriented Carbon Nanotube Networks for UV-Assisted Gas Sensing Applications
PublicationWe investigated the noise and photoresponse characteristics of various optical transparencies of nanotube networks to identify an optimal randomly oriented network of carbon nanotube (CNT)-based devices for UV-assisted gas sensing applications. Our investigation reveals that all of the studied devices demonstrate negative photoconductivity upon exposure to UV light. Our studies confirm the effect of UV irradiation on the electrical...
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Analysis of the Accuracy of Pulse Estimation Using Smart Watches
PublicationThe purpose of this paper is to perform an analysis of the accuracy of the pulse estimation by comparing readings from a smartwatch with readings from medical devices. The study required writing applications that allow continuous pulse measurement. As a result, two applications were created for the smartwatch. The first one is dedicated to Android Wear devices, while the other one is compatible with Tizen watches. The next step...
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The effects of vehicle restraint systems on road safety
PublicationKey to understanding the needs and tools of road infrastructure management for preventing run-off-road crashes or minimising their consequences, is to identify the hazads and sources of hazards caused by wrong or improper use of road safety devices and identify errors in the desifn, structure, construction and operation of road safety devices. Studying such an extended scope of the problem required fieldwork and surveys with road...
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Train the trainer course
PublicationThis chapter presents the concept, evaluation and evaluation results for the train the trainer. This concept of train the trainers is prepared within Workpackage 5 of EU-funded project: MASTER BSR (Erasmus+ Strategic Partnership Programme). Due to the nature of adult learning the content is designed for the use of participatory methods (involved, active). This method uses various techniques of active learning e.g. group work,...
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Expert opinion on the effectiveness of protection against electric shock in case of fault in an installation for electric vehicles charging
PublicationThe opinion concerns the use of residual current devices for protection against electric shock by automatic disconnection of supply in a Norwegian installation intended for charging of electric vehicles.
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Alkohol-społeczny problem XXI wieku. Zastosowanie biowskaźników spożywania alkoholu w diagnostyce medycznej.
PublicationAlkohol etylowy jest legalną i ogólnodostępną substancją o działaniu psychoaktywnym. Spożywany w niewielkich ilościach może pozytywnie wpływać na zdrowie, ale jego nadmierna konsumpcja powoduje silne uzależnienie. Może być to przyczyną agresywnych zachowań, przemocy w rodzinie, problemów w kontaktach z ludźmi, problemów z prawem, samobójstw, wypadków samochodowych oraz problemów finansowych. Dlatego też, szybka i jednoznaczna diagnostyka...
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Augmenting digital documents with negotiation capability
PublicationActive digital documents are not only capable of performing various operations using their internal functionality and external services, accessible in the environment in which they operate, but can also migrate on their own over a network of mobile devices that provide dynamically changing execution contexts. They may imply conflicts between preferences of the active document and the device the former wishes to execute on. In the...
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Analysis of the Usefulness of Cheap Audio Recorders for Spectral Measurement of Environmental Noise
PublicationEnvironmental noise pollution is nowadays one of the most serious health threats. The impact of noise on the human body depends not only on the sound level but also on its spectral distribution. Reliable measurements of the environmental noise spectrum are often hampered by the very high price of top quality measuring devices. This paper explores the possibility of using much cheaper audio recorders for the frequency analysis....
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Analysis of human behavioral patterns
PublicationWidespread usage of Internet and mobile devices entailed growing requirements concerning security which in turn brought about development of biometric methods. However, a specially designed biometric system may infer more about users than just verifying their identity. Proper analysis of users’ characteristics may also tell much about their skills, preferences, feelings. This chapter presents biometric methods applied in several...
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The effect of laser on metal surfaces for multidisciplinary usage in material and thermal engineering
PublicationThe subject of heat transfer and cooling systems is still a matter of contention in many different fields of science and industry. Infrigidation is much more difficult than warming, and so, much more needed in more and more different devices, starting from massive industrial machinery and air conditioning in commercial buildings, up to micro and nano-surgery tools. In fact, the size of many cooling systems is still a problem. It...
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Realizacja mobilnego urządzenia do wytwarzania kurtyny elektromagnetycznej do zastosowań specjalnych
PublicationIn the article the assumptions, design and realisation of the technological demonstrator of a mobile device for generating an electromagnetic curtain (AEGIS) were presented, both in the area of hardware and software. The device is designed to block radio communication by which it is possible to detonate the Radio Controlled Improvised Explosive Devices (RCIEDs). The preliminary laboratory tests of the demonstrator for generating...
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Factors causing degradation of sulfadimetoxine
PublicationSulfadimetoxine is a representative of sulfonamide drugs which presence inhibits growth of activated sludge bacteria, rhat is necessary for the effective mineralization of organic and inorganic contaminants. Therefore factors which con prevent this situation are searched. Aim of this study is selection of conditions causing efficien degradation of the drug- sulfadimetoxine. The impact of such aspects as : the type of oxidizing...
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Symbolic multibody models for digital-twin applications
PublicationSymbolic generation of multibody systems equations of motion appeared in the 1980s. In addition to their computational advantage over their numerical counterparts, symbolic models can be very easily and straightforwardly interfaced with a wide range of software environments and hardware devices. These two features place this approach in a pole position to participate and intervene in the design of digital twins for systems such...
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DOP and Pseudorange Error Estimation in Mobile GNSS Systems for Android OS Applications
PublicationIn the near past, GNSS (Global Navigation Satellite Systems) were only offered for a narrow group of recipients. Nowadays, thanks to mobile devices, they are available to anyone and everywhere. Personal navigation, searching for POI (Point of Interest), etc., had become a basic essential activity. Thanks to the widespread and availability of smartphones each user can obtain information considering his or her location even in an...
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Visualizing Carotid Bodies With Doppler Ultrasound Versus CT Angiography: Preliminary Study
PublicationOBJECTIVE. The purpose of this article is to evaluate the utility of ultrasound in identifying carotid bodies (CBs) in patients with drug-resistant arterial hypertension. SUBJECTS AND METHODS. We enrolled 13 patients with drug-resistant hypertension into a trial for surgical CB excision. CT angiography (CTA) and Doppler ultrasound (DUS) of the cervical arteries were performed before surgery. CBs were identified in a blind manner...
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Mechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by antitumor triazoloacridinone C-1305.
Publication5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone, C-1305, is a promising antitumor therapeutic agent with high activity against several experimental tumors. It was determined to be a potent and selective inhibitor of liver microsomal and human recombinant cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1305 might modulate the effectiveness of other drugs used in multidrug therapy. The objective of this study was...
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Thermodynamics and kinetics of amphotericin B self-association in aqueous solution characterized in molecular detail
PublicationAmphotericin B (AmB) is a potent but toxic drug commonly used to treat systemic mycoses. Its efficiency as a therapeutic agent depends on its ability to discriminate between mammalian and fungal cell membranes. The association of AmB monomers in an aqueous environment plays an important role in drug selectivity, as oligomers formed prior to membrane insertion – presumably dimers – are believed to act differently on fungal (ergosterol-rich)...
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Methods of estimating the cost of traffic safety equipment’s life cycle
Publicationn the article, the authors discuss the preliminary information necessary to determine the scope and direction of further research conducted within the project called “The influence of time and operating conditions on the durability and functionality of road safety elements”. The main objective of the project is to develop the concept of a method for optimizing the life cycle costs of road safety devices. The authors draw attention...
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AEGIS – Mobile Device for Generating Electromagnetic Curtain for Special Applications and Countering the Threats of RCIED
PublicationIn the article the assumptions, design and realization of the technological demonstrator of a mobile device for generating an electromagnetic curtain (with a cryptonym AEGIS) were presented, both in the area of hardware and software. The device is designed to block the radio communication systems by which it is possible to detonate the Radio Controlled Improvised Explosive Devices (RCIEDs). The preliminary laboratory tests of the...
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Molecular detection of Candida krusei
PublicationThe species identification of fungi belonging to genus Candida is an important issue as this genus becomes the emerging problem of nosocomial infections. As Candida krusei presents intrinsicresistance to the fluconazole that is the drug of the first choice in case of invasive candidiasis the PCR identifying the DNA of C. krusei was elaborated. The analytical sensitivity of the assay on spiked blood samples was estimated at 3-5...
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Pathological brain network activity: memory impairment in epilepsy
PublicationOur thinking, memory and cognition in general, relies upon precisely timed interactions among neurons forming brain networks that support cognitive processes. The surgical evaluation of drug-resistant epilepsy using intracranial electrodes provides a unique opportunity to record directly from human brain and to investigate the coordinated activity of cognitive networks. In this issue of Neurology®, Kleen and colleagues1 implicate...
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Performance evaluation of the parallel object tracking algorithm employing the particle filter
PublicationAn algorithm based on particle filters is employed to track moving objects in video streams from fixed and non-fixed cameras. Particle weighting is based on color histograms computed in the iHLS color space. Particle computations are parallelized with CUDA framework. The algorithm was tested on various GPU devices: a desktop GPU card, a mobile chipset and two embedded GPU platforms. The processing speed depending on the number...
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Evaluation of the efficiency of the duty cycle of refuse collection vehicle based on real-world data
PublicationIn this paper a method of the efficiency evaluation of the duty cycle of Refuse Collection Vehicle is presented. Using real world data, two representative duty cycles were analysed. Total cycle efficiency was calculated, as well as the efficiency of particular cycle phases. Then, energy needed to collect and compact the waste and energy from fuel were compared. Measured and calculated values were shown on the diagrams illustrating...
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NADZOROWANIE WYPOSAŻENIA DO MONITOROWANIA I POMIARÓW WEDŁUG WYMAGAŃ WYBRANYCH NORM ORAZ PRZEPISÓW PRAWNYCH
Publication: Przyrządy pomiarowe stanowią zasadniczy element złożonego systemu oceny jakości wyrobów na wszystkich etapach produkcji. Odpowiednio zaprojektowane procedury opisujące procesy kontrolne i pomiarowe, sprawnie zorganizowane i przeprowadzane operacje monitorowania i pomiarów parametrów procesów i produktów oraz skutecznie funkcjonujący nadzór nad wyposażeniem do monitorowania i pomiarów w organizacji są podstawą do wykazania, że...
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Mobile Gas Chromatographs Coupled with Mass and Ion Mobility Spectrometers and their Applications
PublicationThe articles describes the developments un combining of mass and ion mobility spectrometers (MS, IMS0 with miniature gas chromatographs (GC). The examples of applications of miniaturised GC-MS and GC-IMS devices are presented.
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Phase I and phase II metabolism simulation of antitumor-active 2-hydroxyacridinone with electrochemistry coupled on-line with mass spectrometry.
PublicationHere, we report the metabolic profile and the results of associated metabolic studies of 2-hydroxyacridinone (2-OH-AC), the reference compound for antitumor-active imidazo- and triazoloacridinones. Electrochemistry coupled with mass spectrometry was applied to simulate the general oxidative metabolism of 2-OH-AC for the first time. The reactivity of 2-OH-AC products to biomolecules was also examined. The usefulness of the electrochemistry...
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Evaluation of possibilities in identification and susceptibility testing for Candida glabrata clinical isolates with the Integral System Yeast Plus (ISYP)
PublicationThe aim of this study was to evaluate possibilities of correct identification and susceptibility testing of C. glabrata clinical isolates with Integral System Yeast Plus (ISYP). For species identification, as the reference method, API Candida test and species-specific PCR reactions were used. The potential of antifungal susceptibility testing by the ISYP test was compared with the Sensititre Yeast One. Whilst the reference methods...
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CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells
PublicationHigh CYP3A4 expression sensitizes tumor cells to certain antitumor agents while for others it can lower their therapeutic ef fi cacy. We have elucidated the in fl uence of CYP3A4 overexpression on the cellular response induced by antitumor acridine derivatives, C-1305 and C-1748, in two hepatocellular carcinoma (HepG2) cell lines, Hep3A4 stably transfected with CYP3A4 isoenzyme, and HepC34 expressing empty vector. The compounds...
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Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers
PublicationMultidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR cells display a marked increase in lysosome number. We further demonstrate that imidazoacridinones (IAs), which are cytotoxic fluorochromes,...
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Organic solvents aggregating and shaping structural folding of protein, a case study of the protease enzyme
PublicationLow solubility of reactants or products in aqueous solutions can result in the enzymatic catalytic reactions that can occur in non-aqueous solutions. In current study we investigated aqueous solutions containing different organic solvents / deep eutectic solvents (DESs) that can influence the protease enzyme's activity, structural, and thermal stabilities. Retroviral aspartic protease enzyme is responsible for the cleavage of the...
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Molecular mechanism of proton-coupled ligand translocation by the bacterial efflux pump EmrE
PublicationThe current surge in bacterial multi-drug resistance (MDR) is one of the largest challenges to public health, threatening to render ineffective many therapies we rely on for treatment of serious infections. Understanding different factors that contribute to MDR is hence crucial from the global “one health” perspective. In this contribution, we focus on the prototypical broad-selectivity proton-coupled antiporter EmrE, one of the...
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Antifungal Activity of Capridine β as a Consequence of Its Biotransformation into Metabolite Affecting Yeast Topoisomerase II Activity
PublicationIn the last few years,increasing importance is attached to problems caused by fungal pathogens. Current methods of preventing fungal infections remain unsatisfactory. There are several antifungal compounds whichare highly effective in some cases, however, they have limitations in usage: Nephrotoxicity and other adverse effects. In addition, the frequent use of available fungistatic drugs promotes drug resistance....
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The Substantial Improvement of Amphotericin B Selective Toxicity Upon Modification of Mycosamine with Bulky Substituents
PublicationAbstract: Background: It is assumed that the unfavorable selective toxicity of an antifungal drug Amphotericin B (AmB) can be improved upon chemical modification of the antibiotic molecule. Objective: The aim of this study was verification of the hypothesis that introduction of bulky substituents at the amino sugar moiety of the antibiotic may result in diminishment of mammalian vitro toxicity of thus prepared AmB derivatives. Methods:...
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Information-driven network resilience: Research challenges and perspectives
PublicationInternet designed over 40 years ago was originally focused on host-to-host message delivery in a best-effort manner. However, introduction of new applications over the years have brought about new requirements related with throughput, scalability, mobility, security, connectivity, and availability among others. Additionally, convergence of telecommunications, media, and information technology was responsible for transformation...
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Analysis of noise properties of the optocoupler device
PublicationIn the paper the localization of a source of Random Telegraph Signal noise (RTS noise) in optocoupler devices type CNY 17 were defined. The equivalent noise circuit in low frequency noise for these type optocouplers was proposed.
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Electrochemical simulation of enzymatic transformations studied for the selected antitumor acridine derivatives
PublicationThe elucidation of the metabolic pathways and the biotransformation mechanisms of potential drugs is a crucial point in drug development. It allows to know the activation routes of the new biologically active compounds, especially in respect to their possible toxicity. Generally, in vivo or in vitro experiments with liver microsomes or hepatocytes are performed. However, these testing schemes are tedious, time consuming and of...
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Effects of Addictive Substances During Pregnancy and Infancy and Their Analysis in Biological Materials
PublicationThe use of addictive substances during pregnancy is a serious social problem, not only because of effects on the health of the woman and child, but also because drug or alcohol dependency it detracts from childcare and enhances the prospect of child neglect and family breakdown. Developing additive substance abuse treatment programs for pregnant women is socially important and can help ensure the health of babies, prevent subsequent...
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Optical Sensor Based Gestures Inference Using Recurrent Neural Network in Mobile Conditions
PublicationIn this paper the implementation of recurrent neural network models for hand gesture recognition on edge devices was performed. The models were trained with 27 hand gestures recorded with the use of a linear optical sensor consisting of 8 photodiodes and 4 LEDs. Different models, trained off-line, were tested in terms of different network topologies (different number of neurons and layers) and different effective sampling frequency...