Search results for: HUMAN BODY
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Structure-based design and evaluation of novel N-phenyl-1H-indol-2-amine derivatives for fat mass and obesity-associated (FTO) protein inhibition
PublicationFat mass and obesity-associated (FTO) protein contributes to non-syndromic human obesity which refers to excessive fat accumulation in human body and results in health risk. FTO protein has become a promising target for anti-obesity medicines as there is an immense need for the rational design of potent inhibitors to treat obesity. In our study, a new scaffold N-phenyl-1H-indol-2-amine was selected as a base for FTO protein inhibitors...
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Imunofan—RDKVYR Peptide—Stimulates Skin Cell Proliferation and Promotes Tissue Repair
PublicationRegeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today’s science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical specialties. In this study, we...
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Electrophoretic Deposition and Characterization of Chitosan/Eudragit E 100 Coatings on Titanium Substrate
PublicationCurrently, a significant problem is the production of coatings for titanium implants, which will be characterized by mechanical properties comparable to those of a human bone, high corrosion resistance, and low degradation rate in the body fluids. This paper aims to describe the properties of novel chitosan/Eudragit E 100 (chit/EE100) coatings deposited on titanium grade 2 substrate by the electrophoretic technique (EPD). The deposition...
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ECG measurement in the bathtub - drl on one side of the bathtub, the other side of the bathtub is grounded and the system ground is grounded- men
Open Research DataThe measurement data shows the measurement of the ECG signal in water in the bathtub. The data includes the measurement time, the reference ECG signal from the chest, and the ECG signal measured by electrodes placed in the bathtub without contact with the human body. Using the presented data, it is possible to estimate the optimal arrangement of measuring...
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Testing and sampling devices for monitoring volatile and semi-volatile organic compounds in indoor air
PublicationAdults spend most of their time in enclosed spaces (e.g., apartment, office and public buildings). According to research conducted by scientists, air quality indoors is much worse than the ambient air quality outdoors. Hazardous chemicals found in air indoors can adversely affect the functioning of the human body and cause many respiratory and circulatory diseases. Harmful chemical compounds (mainly volatile organic compounds and...
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Influence of Additional Loads on Chosen Gait Parameters and Muscles Activity
PublicationThis paper is devoted to human motion analysis and comparison of chosen kinematics parameters during normal gait with and without additional load in a form of backpack. A stability in both cases were compared in both frontal and sagittal planes, by applying a video tracking system. Experimental tests performed on treadmill, passive markers, placed on volunteers bare skin were used. Additionally, an infra-red camera was employed...
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The occurence and diagnosis of biomarkers of ethyl alcohol consumption
PublicationEthyl alcohol is a legal and a widely available psychoactive drug. However, its excessive consumption causes addiction. This leads to aggressive behaviors, family battery, difficulties in interpersonal relations, legal offences, suicides, car accidents and deterioration in labor productivity, what causes financial problems. Despite many social actions against alcohol consumption, this problem is still unresolved. Therefore, fast...
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Photoplethysmographic Time-Domain Heart Rate Measurement Algorithm for Resource-Constrained Wearable Devices and its Implementation
PublicationThis paper presents an algorithm for the measurement of the human heart rate, using photoplethysmography (PPG), i.e., the detection of the light at the skin surface. The signal from the PPG sensor is processed in time-domain; the peaks in the preprocessed and conditioned PPG waveform are detected by using a peak detection algorithm to find the heart rate in real time. Apart from the PPG sensor, the accelerometer is also used to...
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Effects of black cohosh extract on body weight gain, intra-abdominal fat accumulation, plasma lipids and glucose tolerance in ovariectomized Sprague–Dawley rats
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A comparison of muscle activity of the dominant and non-dominant side of the body during low versus high loaded bench press exercise performed to muscular failure
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Comment on “Anti-cooperativity in hydrophobic interactions: A simulation study of spatial dependence of three-body effects and beyond” [J. Chem. Phys. 115, 1414 (2001)]
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Do Body Composition and Values of Selected Nutritional Status Indices Influence the Glycaemic Index Values of Vegetarian Dishes? A Pilot Study in a Group of Older Women
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An IoT-Based Computational Framework for Healthcare Monitoring in Mobile Environments
PublicationThe new Internet of Things paradigm allows for small devices with sensing, processing and communication capabilities to be designed, which enable the development of sensors, embedded devices and other ‘things’ ready to understand the environment. In this paper, a distributed framework based on the internet of things paradigm is proposed for monitoring human biomedical signals in activities involving physical exertion. The main...
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Antimicrobal and ostheointegration activity of bone cement contains nanometals
PublicationPurpose: One of the major problems in bone surgery are infections – especially thoseoccurring in the course of the operating on the patients with lowered immunity system,because they carry the danger of complications. In the Mechanical Department of TechnicalUniversity of Gdansk, there has been carried the research with the use of bone cement andmetal nanoparticles.Design/methodology/approach: The bone cement was used without supplement...
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Widespread theta synchrony and high-frequency desynchronization underlies enhanced cognition
PublicationThe idea that synchronous neural activity underlies cognition has driven an extensive body of research in human and animal neuroscience. Yet, insufficient data on intracranial electrical connectivity has precluded a direct test of this hypothesis in a whole-brain setting. Through the lens of memory encoding and retrieval processes, we construct whole-brain connectivity maps of fast gamma (30-100 Hz) and slow theta (3-8 Hz) spectral...
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Imunofan - RDKVYR peptide - stimulates skin cell proliferation and promotes tissue repair
PublicationRegeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today's science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical...
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3-MCPD: A worldwide problem of food chemistry
Publication3-MCPD is a heat-induced food contaminant which has been widely investigated for decades. This paper presents an overview of current knowledge about 3-MCPD including its formation routes, occurrence in various foodstuffs, analytical approach, toxicological aspects and future research perspectives. So far 3-MCPD was determined in its free and bound form in thermally-treated foods, edible oils and fats, and infant foods including...
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Melanoma skin cancer detection using mask-RCNN with modified GRU model
PublicationIntroduction: Melanoma Skin Cancer (MSC) is a type of cancer in the human body; therefore, early disease diagnosis is essential for reducing the mortality rate. However, dermoscopic image analysis poses challenges due to factors such as color illumination, light reflections, and the varying sizes and shapes of lesions. To overcome these challenges, an automated framework is proposed in this manuscript. Methods: Initially, dermoscopic...
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Filozofować z głębi człowieczeństwa. O fenomenologii Andrzeja Półtawskiego.
PublicationDokonując krytyki tradycji nowożytnego empiryzmu i kartezjańskiego dualizmu Półtawski tworzy realistyczną i dynamiczną interpretację bytu ludzkiego. Przeżywanie, odczuwanie zmysłowe nie jest poślednią odmianą poznania jak i operacją dostarczania jedynie elementów, budulca poznaniu, ale odrębnym sposobem bycia w świecie, jest symbiotycznym kontaktem z otoczeniem, formą życia. Zrywa on radykalnie z tradycją brentanowsko-husserlowską...
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Quantification of ultrafine airborne particulate matter generated by the wear of car brake materials
PublicationThe wear of car brakes is one of the main sources of airborne particulate matter in urban environments. Ultrafine wear particles are of special environmental interest since they can easily penetrate the human body through inhalation and cause various diseases. In the present study, the contribution of ultrafine particles to airborne particulate matter emitted from car brake materials was investigated under different friction conditions....
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Corrosion degradation of spacers – examination of changes in bone cement coating.
PublicationSpacer is a special implant used at the time of infection after endoprosthetic surgery. It consists of a metal core and bone cement coating with an antibiotic. In the human body spacers are exposed to degradation processes. This paper looks at the effect of corrosion on spacers. Electrochemical corrosion tests were performer on titanium pins with bone cement coating in two solutions: Ringer’s solution and artificial...
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Assessment of Lipophilicity Indices Derived from Retention Behavior of Antioxidant Compounds in RP-HPLC
PublicationReverse phase high pressure liquid chromatography was employed in order to evaluate the lipophilicity of antioxidant compounds from different classes, such as phenolic acids, flavanones, flavanols, flavones, anthocyanins, stilbenes, xantonoids, and proanthocyanidins. The retention time of each compound was measured using five different HPLC columns: RP18 (LiChroCART, Purosphere RP-18e), C8 (Zorbax, Eclipse XDBC8), C16-Amide (Discovery...
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Ocena wpływu pokarmowych kwasów nukleinowych i ich komponentów na replikacyjną i naprawczą syntezę DNA w modelach komórek ludzkiego układu pokarmowego
PublicationKwasy nukleinowe, do których należą DNA i RNA, są podstawowymi elementami każdej komórki niezbędnymi do prawidłowego funkcjonowania organizmu. Pomimo, że cząsteczki te stanowią również nieodłączne składniki produktów żywnościowych spożywanych przez człowieka, to badania na temat ich zawartości w żywności oraz wartości odżywczej są ograniczone. Wyniki uzyskane w niniejszej pracy doktorskiej pokazały istotne różnice w ilości, wielkości...
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Biometryczna kontrola dostępu
PublicationOpisano szczegółowo algorytm detekcji oraz identyfikacji człowieka na podstawie punktów nodalnych twarzy. Zdefiniowano pojęcia: biometria, proces pomiaru biometrycznego, metody biometrycznej identyfikacji oraz kontrola dostępu. Przedstawiono opis opracowanego systemu biometrycznej identyfikacji wykorzystującego sztuczne sieci neuronowe. Podano wyniki badań oraz przeprowadzono ich wnikliwą dyskusję.Biometrics is the study of automated...
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A compartment model of alveolar–capillary oxygen diffusion with ventilation–perfusion gradient and dynamics of air transport through the respiratory tract
PublicationThis paper presents a model of alveolar–capillary oxygen diffusion with dynamics of air transport through the respiratory tract. For this purpose electrical model representing the respiratory tract mechanics and differentia equations representing oxygen membrane diffusion are combined. Relevant thermodynamic relations describing the mass of oxygen transported into the human body are proposed as the connection between these models,...
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Application of ion chromatography with pulsed amperometric detection for the determination of trace cyanide in biological samples, including breast milk
PublicationCyanide (CN) is the biomarker of exposure to the components of tobacco smoke, although its presence in biological samples is also due to the consumption of products containing cyanogenic glycosides. In this work, we determine the concentration of the free cyanide in urine, saliva and breast milk matrices, using ion chromatography with pulsed amperometric detection (IC-PAD). IC-PAD is an emerging method, with only few documented...
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Deep learning based thermal image segmentation for laboratory animals tracking
PublicationAutomated systems for behaviour classification of laboratory animals are an attractive alternative to manual scoring. However, the proper animals separation and tracking, especially when they are in close contact, is the bottleneck of the behaviour analysis systems. In this paper, we propose a method for the segmentation of thermal images of laboratory rats that are in close contact during social behaviour tests. For this, we are...
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Employees With Autism Spectrum Disorders in the Digitized Work Environment: Perspectives for the Future
PublicationThe aim of this article is to examine the opportunities for employees with autism spectrum disorders (ASDs), arising from digital technology (DT) development. The author discusses assistive technology (AT) as a mean of creating a better work environment, making the digitized workplace more friendly for people with ASD. A possible solution of communication problems is replacing the interpersonal communication between employees with...
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Ordered titanium templates functionalized by gold films for biosensing applications – Towards non-enzymatic glucose detection
PublicationRecently, metal nanostructures evoke much interest due to application potential in highly sensitive detectors in biochemistry and medical diagnostics. In this work we report on preparation and characteristics of thin (1–100 nm) Au films deposited onto highly ordered structured titanium templates for SERS (Surface Enhanced Raman Spectroscopy) and electrochemical sensing. The Ti templates are formed by selective removal of TiO2 nanotubes...
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Significant Decrease in Glycated Hemoglobin, 2h-Post-Load Glucose and High-Sensitivity C-Reactive Protein Levels in Patients with Abnormal Body Mass Index after Therapy with Manual Lymphatic Drainage
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Golden artefacts, resin figurines, body adhesives and tomb sediments from the pre-Columbian burial site El Caño (Gran Coclé, Panamá): tracing organic contents using molecular archaeometry
PublicationThis research aimed to determine the origin of organic residues from funerary contexts in the El Ca~no settlement (Gran Cocl�e area, Panam�a, Central America) by means of multiple molecular probing techniques (GC-MS of organic solvent extracts and pyrolysis-GC-MS, THM-GC-MS and FTIR of solid samples). The samples include particles of precious resin figurines, fillings of golden objects, tomb sediments, plant exudates from extant...
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Clinical studies of detecting COVID-19 from exhaled breath with electronic nose
PublicationThe COVID‑19 pandemic has attracted numerous research studies because of its impact on society and the economy. The pandemic has led to progress in the development of diagnostic methods, utilizing the polymerase chain reaction (PCR) as the gold standard for coronavirus SARS‑CoV‑2 detection. Numerous tests can be used at home within 15 min or so but of with lower accuracy than PCR. There is still a need for point‑of‑care tests available...
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A Flexible Nafion Coated Enzyme‐free Glucose Sensor Based on Au‐dimpled Ti Structures
PublicationThe detection of glucose at low concentrations using electrochemical sensors is of great importance due to the possibility of using different human body fluids than blood, such as e.g. urine, saliva, sweat or tears. The interest behind those biofluids is related to their utility in non-invasive sugar determination. In this work, we present flexible, fully biocompatible electrode material based on Au nanoparticles immobilized onto...
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Polyurethane Composite Scaffolds Modified with the Mixture of Gelatin and Hydroxyapatite Characterized by Improved Calcium Deposition
PublicationThe skeleton is a crucial element of the motion system in the human body, whose main function is to support and protect the soft tissues. Furthermore, the elements of the skeleton act as a storage place for minerals and participate in the production of red blood cells. The bone tissue includes the craniomaxillofacial bones, ribs, and spine. There are abundant reports in the literature indicating that the amount of treatments related...
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Seabed Topography Changes in the Sopot Pier Zone in 2010–2018 Influenced by Tombolo Phenomenon
PublicationBathymetric surveys of the same body of water, performed at regular intervals, apart from updating the geospatial information used to create paper and electronic maps, allow for several additional analyses, including an evaluation of geomorphological changes occurring in the coastal zone. This research is particularly important in places where the shape of the coastal zone has been violently disturbed, including by human activity....
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Mass spectrometry based identification of geometric isomers during metabolic stability study of a new cytotoxic sulfonamide derivatives supported by quantitative structure-retention relationships
PublicationA set of 15 new sulphonamide derivatives, presenting antitumor activity have been subjected to a metabolic stability study. The results showed that besides products of biotransformation, some additional peaks occurred in chromatograms. Tandem mass spectrometry revealed the same mass and fragmentation pathway, suggesting that geometric isomerization occurred. Thus, to support this hypothesis, quantitative structure-retention relationships...
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Trophic Transfer of Mercury in a Temperate Marine Food Web, Southern Baltic Sea
PublicationMercury (Hg) is considered to be one of the most dangerous global environmental pollutants. The toxicity and bioavailabilityof Hg depend on its chemical form, and the greatest hazard is posed by the organomercurial compounds. Hg is introduced into the human body primarily through the consumption of fish and seafood. Despite numerous studies on Hg in marine organisms, there is still a gap in the knowledge on Hg uptake and...
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Colour Terms in Five Linguistic Images of the World: The Semantic Perspective
PublicationSocial and cultural factors shape the linguistic perception of colour. At the same time, colour terms co-create the linguistic image of the world, which allows us to interpret reality and profile our statements and beliefs. This paper presents six basic colour terms: white, black, red, green, yellow, and blue (both as adjectives and as nouns) in the five different linguistic images of the world of the following languages: English,...
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DC and AC Conductivity, Biosolubility and Thermal Properties of Mg-Doped Na2O–CaO–P2O5 Glasses
PublicationBioactive glasses have recently been extensively used to replace, regenerate, and repair hard tissues in the human body because of their ability to bond with living tissue. In this work, the effects of replacing Na2O with MgO on the electrical, biosolubility, and thermal properties of the target glass 10Na2O–60P2O5–30CaO (in mol%) were investigated. The electrical properties of the glasses were studied with the impedance spectroscopy...
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Non-enzymatic flexible glucose sensing platform based on nanostructured TiO2–Au composite
PublicationAll over the world the number of people suffering from diabetes and related complications is drastically growing. Therefore, the need for accurate, reliable and stable sensor for monitoring of glucose in human body fluids is becoming highly desirable. In this work we show that material composed of gold layers deposited onto TiO2 nanotubes (NTs) formed onto the flexible Ti foil exhibits great response toward glucose oxidation and...
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PARAMETERS OF THE ELECTROPHORETIC DEPOSITION PROCESS AND ITS INFLUENCE ON THE MORPHOLOGY OF HYDROXYAPATITE COATINGS. REVIEW
PublicationMetallic materials intended for bone implants should exhibit not only appropriate mechanical properties, but also high biocompatibility. The surface treatment modifications, for example acidic treatment, laser treatment, ion implantation and deposition of highly biocompatible coatings, are practiced. One of the most popular methods of surface modification is to deposit hydroxyapatite (HAp) coatings. HAp naturally occurs in human...
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Wykorzystanie kamery termowizyjnej nowej generacji do oceny wpływu sił ortodontycznych na dziąsło = The application of a new-generation thermal imaging camera for the assessment of hemodynamic changes in gingiva during orthodontic treatment
PublicationIntroduction. One ot the most interesting modern methods of assessing microcirculation is thermovisiual examination. Thermovision cameras are commonly used in general medicine. As the periodontium is one of the most vascularized tissues in the human body, the application of high-sensitivity thermovision cameras may allow tor noninvasive asses- sment and early detection ot pathological changes in the gingiva by giving a complete...
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The mechanisms of degradation of titanium dental implants
PublicationTitanium dental implants show very good properties, unfortunately there are still issues regarding material wear due to corrosion, implant loosening, as well as biological factors—allergic reactions and inflammation leading to rejection of the implanted material. In order to avoid performing reimplantation operations, changes in the chemical composition and/or modifications of the surface layer of the materials are used. This research...
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Bacteriophages as potential tools for use in antimicrobial therapy and vaccine development
PublicationThe constantly growing number of people suffering from bacterial, viral, or fungal infections, parasitic diseases, and cancers prompts the search for innovative methods of disease prevention and treatment, especially based on vaccines and targeted therapy. An additional problem is the global threat to humanity resulting from the increasing resistance of bacteria to commonly used antibiotics. Conventional vaccines based on bacteria...
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Blood concentrations of a new psychoactive substance 4-chloromethcathinone (4-CMC) determined in 15 forensic cases
PublicationPurpose: The 4-chloromethcathinone (4-CMC) is a synthetic derivative of cathinone and belongs to new psychoactive substances. Neither data on the effects of 4-CMC on the human body, nor on nontoxic, toxic and lethal concentrations in biological materials have been published in the literature. This paper describes the results of an analysis of the blood concentrations of 4-CMC determined in 15 forensic cases related to nonfatal...
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Phospholipids as potential prevention factor in carcinogenesis
PublicationPhospholipids are a group of complex lipids, which can be used in cancer chemoprevention. Glicerophospholipids are composed of fatty acids esterified to a glycerol backbone, a phosphate group and a hydrophilic residue such as: cho- line, ethanoloamine, serine or inositol. In the sn-2 position of glicerophospholipid usually there are unsaturated fatty acids, i.e. linolenic acid, while in the sn-1 position more typi- cal are saturated...
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WEB-CAM AS A MEANS OF INFORMATION ABOUT EMOTIONAL ATTEMPT OF STUDENTS IN THE PROCESS OF DISTANT LEARNING
PublicationNew methods in education become more popular nowadays. Distant learning is a good example when teacher and student meet in virtual environment. Because interaction in this virtual world might be complicated it seems necessary to assure as much methods of conforming that student is still engaged in the process of learning as it is possible. We would like to present assumption that by means of web-cam we will be able to track facial...
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Electrochemistry meets enzymes: Investigation of the biotransformation pathway of C-1311 based on electrochemical simulation in comparison to in vitro methods.
PublicationThe knowledge of the metabolic pathways and the biotransformation of new drugs is one of the major challenges in pharmaceutical research. It is crucial for elucidation of degradation routes of the new biologically active compounds, especially in the area of possible toxicity. Conventional in vitro drug metabolism studies are based on incubating drug candidate with e.g. hepatocytes or, most importantly, liver cell microsomes and...
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Daily diet containing canned products significantly increases serum concentrations of endocrine disruptor bisphenol A in young women
PublicationNowadays, exposure to environmental factors is considered to be one of the possible causes of several lifestyle diseases, such as obesity, type 2 diabetes, cardiovascular disease, and cancer. Particularly noteworthy are endocrine‑disrupting chemicals (EDCs), which affect the metabolism of hormones and interact with their receptors, thus exerting adverse health effects. One of the most ubiquitous EDC in daily life is bisphenol A...
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Cluster donation: How medical students bound certain types of tissues and biomedical research and how it affects their willingness to donate.
PublicationAlthough biomedical research requires cooperation with a large number of donors, its success also depends on the input of healthcare professionals who play a crucial role in promoting biomedical research and influencing an individual’s decision to donate one’s biospecimens that are left over after a medical procedure. This work was aimed at investigating the correlation between medical and healthcare students’ willingness to...