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Wyniki wyszukiwania dla: drug screening platform
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Reliable underwater communication system for shallow coastal waters
PublikacjaThis paper presents a reliable and robust low data rate spread spectrum approach which is implemented in the acoustic underwater communication system for shallow coastal waters. It shows operation assumptions of spread spectrum techniques based on the wellknown Shannon equation. It describes two methods of spread spectrum: frequency hopping spread spectrum and direct sequence spread spectrum; their block diagram and their characteristics...
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Implementation of TVDI calculation for coastal zone
PublikacjaPaper will show an implementation of TVDI (Temperature-Vegetation-Dryness Index) algorithm on GPU (Graphics Processing Unit). Calculation of this index is based on LST (Land Surface Temperature) and NDVI (Normalized Difference Vegetation Index). Discussed results are based on multi-spectral imagery retrieved from AVHRR3 sensors for area of Poland, especially from region of Gdańsk coastal zone. All phases of TVDI implementation...
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High-Precision FIR-Model-Based Dynamic Weighing System
PublikacjaConveyor belt-type checkweighers are increasingly popular components of modern production lines. They are used to assess the weight of the produced items in motion, i.e., without stopping them on the weighing platform. The main challenge one faces when designing a dynamic weighing system is providing high measurement accuracy, especially at high conveyor belt speeds. The approach proposed in this paper can be characterized as a...
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UWB-Based Indoor Navigation in a Flexible Manufacturing System Using a Custom Quadrotor UAV
PublikacjaA novel solution for indoor navigation of a transportation drone in flexible manufacturing is presented in this paper. To address the challenges of accurate and robust drone navigation in occluded environments, an ultra-wideband (UWB) navigation system has been integrated with a commercially available open source control platform. The system offers high accuracy (± 20 mm), low power consumption, resistance to electronic interference,...
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Inference Mechanisms for Knowledge Management System in E-health Environment
PublikacjaW artykule zaprezentowano badania i ich wyniki osiągnięte w trakcie prac na systemem zarządzania wiedzą dla systemu typu e-health PIPS (ang. Personalised Information Platform for Life and Health Services)Opisano warstwę semantyczną systemu zarządzania wiedzą, a w szczególności skoncentrowano się na silniku wnioskującym.Poddano dyskusji następujące zagadnienia: analizę dostępnych narzędzi wnioskujący i ich zgodności ze standardem...
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Tracing of dynamic objects in distributed interactive simulation systems
PublikacjaDistributed interactive simulation systems require integration of several areas of computer science and applied mathematics to enable each individual simulation object to visualize effectively dynamic states of other objects. Objects are unpredictable,i.e., controlled by their local operators, and are remote, i.e., must rely on some transmission media to visualize dynamic scene from their local perspectives. The paper...
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Theoretical and Experimental Studies on the Visible Light Activity of TiO2 Modified with Halide-Based Ionic Liquids
PublikacjaFormation of a surface complex between organic molecules and TiO2 is one of the possible strategies for the development of visible light-induced TiO2 photoactivity. Herein, three ionic liquids (ILs) with the same cation and dierent anions (1-butylpirydynium chloride/bromide/iodide) have been applied for the surface modification of TiO2 and to understand the role of anions in visible light-induced activity of ILs-TiO2 systems. Photocatalytic...
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Applicability of phenolic acids as effective enhancers of cocrystals solubility of methylxanthines
PublikacjaApplicability of phenolic acids as potential cocrystal formers for methylxanthine derivatives was analyzed both in terms of cocrystallization probabilities and solubility advantage. The cocrystal formation abilities were evaluated using mixing enthalpy estimated within the conductor like screening model for real solvents (COSMO-RS) framework. The solubility improvement of potential cocrystals was estimated by formulation of the...
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Miniaturized passive emission test chamber for in-situ measurement of emissions of organic compounds
PublikacjaThe results of many different studies have demonstrated unequivocally that the quality of indoor air is often much worse than that of atmospheric air (outdoor). One of the main groups of chemical compounds present in indoor air, with proven harmfulness to health,are volatile organic compounds (VOCs). VOCs present indoor comprise a wide variety of hydrocarbons and hydrocarbons derivatives including aliphatic, aromatics, alkylbenzens,...
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Magnetic superhydrophobic melamine sponges for crude oil removal from water
PublikacjaThis paper proposes the preparation of a new sorbent material based on melamine sponges (MS) with superhydrophobic, superoleophilic, and magnetic properties. This study involved impregnating the surface of commercially available MS with eco-friendly deep eutectic solvents (DES) and Fe3O4 nanoparticles. The DES selection was based on the screening of 105 eutectic mixtures using COSMO-RS modeling. Other parameters affecting the efficiency...
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FLUID BED COATING OF MINITABLETS AND PELLETS WITH OPTIMIZATION OF THE PROCESS BASED ON TAGUCHI METHOD
PublikacjaSmall particles like pellets are coated in fluid bed systems. This method can be also feasible for minitablets but the selection of optimal process parameters is complicated. The aim of the research was to optimize the coating process for minitablets and to compare the conditions required for pellets. Minimum fluidization velocities (umf) for 2.0 and 2.5 mm minitablets and 0.7-0.8 mm or 1.0-1.25 mm pellets were determined experimentally....
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Beyond clinical care: the pharmacoeconomic and research roles of pharmacists in Poland
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Neuroprotective Effects of Cannabidiol in Hypoxic Ischemic Insult. The Therapeutic Window in Newborn Mice
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Preparation of delayed-release multiparticulate formulations of diclofenac sodium and evaluation of their dissolution characteristics using biorelevant dissolution methods
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DEVELOPMENT OF HYDROGEL CAPSULES FOR USE IN DUAL-PHASE TOPICAL PREPARATIONS CONTAINING DIHYDROXYACETONE AND AMINO ACIDS – PRELIMINARY RESULTS
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ASSESSMENT OF SAFETY OF PAIN CONTROL BY NON-OPIOID OVER-THE COUNTER MEDICATIONS
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THE USE OF OTC HERBAL SEDATIVES BY PHARMACY PATIENTS – A QUESTIONNAIRES-BASED SURVEY STUDY
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In vitro dissolution test of ketoprofene: development and evaluation of release from soft and hard gelatine capsules
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NK1 receptor binding of a few low molecular weight 3,5-bistrifluoromethylbenzene derivatives
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Quantitative chirality in the binding of androgens to their receptor
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The biological activity of new tuftsin derivatives - induction of phagocytosis
PublikacjaFagocytoza odgrywa ważną rolę w ochronie organizmu przed różnymi mikroorganizmami. Proces ten może być indukowany przez różne czynniki np. endogenny immunomodulator jakim jest tuftsyna czy muramylo-dipeptyd (MDP), najmniejszy syntetyczny glikopeptyd bakteryjnej ściany komórkowej. Zsyntetyzowano nowe analogi MDP i nor-MDP z tuftsyną i retro-tuftsyną, które są zdolne do indukowania fagocytozy. Najbardziej obiecujące okazały się dwa...
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Analysis of antioxidant capacity and polyphenol content of Goji fruit products available on the European market
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Determination of API content in a pilot-scale blending by near-infrared spectroscopy as a first step method to process line implementation
PublikacjaNear infrared (NIR) spectroscopy was used for estimation of powder blend homogeneity and manufacturing control of a medicinal product powder mixture containing active pharmaceutical ingredient (API). Aiming at initiating a Process Analytical Technology (PAT) activity, the first step was a stationary mode atline evaluation. In this, the content of pharmaceutical active compound in the powder mixtures intended to the direct tabletting...
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Herbal Resources in the medication of depression during pandemic COVID-19
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A history of the physical and chemical stability of pharmaceuticals : a review
Publikacja: There is a great need for a broad range review of stability tests of active pharmaceutical ingredients (APIs) in comparison with current requirements contained in the pharmacopoeia. This review focuses on a pharmaceutical history of physical and chemical stability determination. Traditional knowledge must be considered in the context of physical stability, while new knowledge must be applied and acquired in terms of identification...
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FROM HARVESTING TO DISTILLATION - EFFECT OF ANALYTICAL PROCEDURES ON THE YIELD AND CHEMICAL COMPOSITION OF RHODODENDRON TOMENTOSUM (LEDUM PALUSTRE) ESSENTIAL OIL
PublikacjaRhododendron tomentosum possesses the anti-inflammatory, analgesic and antimicrobial properties, determined by the chemical composition of its essential oil. The effects of place (Miszewko, Lubichowo) and time of harvesting (June, November) as well as drying (air-drying, oven-drying, freeze-drying) and isolation (in Deryng, Clevenger and Likens-Nickerson apparatus) procedures on the yield and quality of R. tomentosum essential...
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Budesonide treatment of professional athletes and anti-doping testing- case studies
PublikacjaAccording to the World Anti-Doping Agency (WADA) Prohibited List, glucocorticosteroids are prohibited in competition and only when administered by oral, intravenous, intramuscular or rectal routes. Up to now, in order to differentiate whether glucocorticosteroids were administered by one of the prohibited routes or not, a specific reporting limit for urinary concentrations of parent compounds and their metabolites was established...
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CHROMATOGRAPHIC TECHNIQUES IN PHARMACEUTICAL ANALYSIS IN POLAND: HISTORY AND THE PRESENCE ON THE BASIS OF PAPERS PUBLISHED IN SELECTED POLISH PHARMACEUTICAL JOURNALS IN XX CENTURY
PublikacjaFor a long time, chromatographic techniques and techniques related to them have stimulated the development of new procedures in the field of pharmaceutical analysis. The newly developed methods, characterized by improved metrological parameters, allow for more accurate testing of, among others, the composition of raw materials, intermediates and final products. The chromatographic techniques also enable studies on waste generated...
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Voriconazole-Based Salts Are Active against Multidrug-Resistant Human Pathogenic Yeasts
PublikacjaVoriconazole (VOR) hydrochloride is unequivocally converted into VOR lactates and valinates upon reaction with silver salts of organic acids. This study found that the anticandidal in vitro activity of these compounds was comparable or slightly better than that of VOR. The Candida albicans clinical isolate overexpressing CaCDR1/CaCDR2 genes, highly resistant to VOR, was apparently more susceptible to VOR salts. On the other hand,...
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Application of bioassays in studies on the impact of pharmaceuticals on the environment
PublikacjaDrug interactions are often desirable particularly in medicine, when treatment of a patient requires using a mixture of drugs in specific doses to produce the adequate therapeutic effect. Unfortunately, interactions between drugs in the environment are not as desirable, despite the fact that drugs are present in the environment at low concentration levels [1]. Pharmaceuticals are present in the environment in a mixture of compounds,...
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Urinary Tract Infections Caused by K. pneumoniae in Kidney Transplant Recipients – Epidemiology, Virulence and Antibiotic Resistance
PublikacjaUrinary tract infections are the most common complication in kidney transplant recipients, possibly resulting in the deterioration of a long-term kidney allograft function and an increased risk of recipient’s death. K. pneumoniae has emerged as one of the most prevalent etiologic agents in the context of recurrent urinary tract infections, especially with multidrug resistant strains. This paper discusses the epidemiology and risk...
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Determination of Toxicological Parameters of Selected Bioactive Organic Chemicals Using the Ostracodtoxkit FTM
PublikacjaAssessment of the impact of pharmaceutical residues on living organisms is very complex subject. Apart from taking into account the toxicity of individual compounds also their presence in mixtures should be taken into account. In this work, attempts were made to assess the ecotoxicity of biologically active substances (with 50 % effective concentration (EC50) values growing from fluoxetine (EC50 = 4.431 nM) >> gemfibrozil ≈ 17α-ethinylestradiol...
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Low frequency of itraconazole resistance found among avian Aspergillus fumigatus isolates
PublikacjaAspergillus fumigatus is the most frequent etiological factor of invasive aspergillosis in human as well as animals, including birds. Aspergillosis caused by drug-resistant strains poses a significant therapeutic issue, especially if resistance pattern includes insensitivity to triazoles, i.e. drugs recommended for the primary therapy purposes. Majority of resistant isolates hold the TR34/L98H...
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Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase
PublikacjaThe antifungal activity of 5‐hydroxy‐4‐oxo‐L‐norvaline (HONV), exhibited under conditions mimicking human serum, may be improved upon incorporation of this amino acid into a dipeptide structure. Several HONV‐containing dipeptides inhibited growth of human pathogenic yeasts of the Candida genus in the RPMI‐1640 medium, with minimal inhibitory concentration values in the 32 to 64 μg mL−1 range. This activity was not affected by multidrug...
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Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the antitumor imidazoacridinone C-1311 in human hepatoma cells
PublikacjaThere is increasing evidence that the expression level of drug metabolic enzymes affects the final cellular response following drug treatment. Moreover, anti-tumour agents may modulate enzymatic activity and/or cellular expression of metabolic enzymes in tumour cells. We investigated the influence of CYP3A4 overexpression on the cellular response induced by the anti-tumour agent C-1311 in hepatoma cells. C-1311-mediated CYP3A4...
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Glucosamine-6-phosphate synthase with an oligoHis insert
PublikacjaGlucosamine-6-phosphate (GlcN-6-P) synthase known also as L-Glutamine: D-fructose-6-phosphate aminotransferase (EC 2.6.1.16), catalyzes the first committed step in the amino sugar biosynthetic pathway in prokaryotic and eukaryotic organisms. The final product of this pathway is an activated precursor of numerous macromolecules containing amino sugars, including chitin and mannproteins in fungi, peptydoglican and lipopolysaccharides...
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Development and evaluation of RADA-PDGF2 self-assembling peptide hydrogel for enhanced skin wound healing
PublikacjaBackground: Wound healing complications affect numerous patients each year, creating significant economic and medical challenges. Currently, available methods are not fully effective in the treatment of chronic or complicated wounds; thus, new methods are constantly sought. Our previous studies showed that a peptide designated as PDGF2 derived from PDGF-BB could be a promising drug candidate for wound treatment and that RADA16-I...
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Visual Data Encryption for Privacy Enhancement in Surveillance Systems
PublikacjaIn this paper a methodology for employing reversible visual encryption of data is proposed. The developed algorithms are focused on privacy enhancement in distributed surveillance architectures. First, motivation of the study performed and a short review of preexisting methods of privacy enhancement are presented. The algorithmic background, system architecture along with a solution for anonymization of sensitive regions of interest...
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Toward knowledge-grid model for academic purposes
PublikacjaNowadays we face a huge amount of data and information sharing on the Web by different users worldwide. For example, the academic environment is one of such places where teachers share and manage knowledge for groups of students. This paper proposes a multi-dimensional knowledge space model, designed to distribute and manage knowledge resources efficiently. We view our model as a foundation of a knowledge grid platform. Two crucial...
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Septic safe interactions with smart glasses in health care
PublikacjaIn this paper, septic safe methods of interaction with smart glasses, due to the health care environment applications consideration, are presented. The main focus is on capabilities of an optical, proximity-based gesture sensor and eye-tracker input systems. The design of both interfaces is being adapted to the open smart glasses platform that is being developed under the eGlasses project. Preliminary results obtained from the...
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Oxygen biosensor based on carbon nanotubes directly grown on graphitic substrate
PublikacjaFilms of carbon nanotubes were synthesized on the graphitic substrates by CVD method in the presence of catalyst. Two different catalysts were used, that is nickel and iron, supported on graphitic substrates. The as-obtained nanotubes were analyzed by SEM imaging with EDX and Raman spectroscopy. The results revealed their multi-walled morphology. Free radical reaction was carried out in order to chemically functionalize synthesized...
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EMG and gaze based interaction with graphic interface of smart glasses application
PublikacjaIn this paper we investigate the effectiveness of the interaction using eye tracking and electromyography. Smart glasses requires reliable interfaces for controlling the graphic content displayed directly in front of the user's eye. Presented research is related with the eGlasses project, which is focused on the development of an open platform in the form of multisensory electronic glasses and related interaction methods. One of...
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Influence of the jitter buffer on the quality of service VoIP.
PublikacjaVoIP (Voice over IP) is a modern service with enormous potential for yet further growth. It uses the already available and universally implemented IP transport platform. One significant problem, however, is ensuring the Quality of Service, abbreviated QoS. This paper addresses exactly that issue. In an extensive investigation the influence of jitter buffers on QoS is being examined in depth. Two implementations, namely a passive...
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Optical glyphs based localization and identification system
PublikacjaThe paper presents a description of functioning of a platform supporting the detection of obstructive diseases in the respiratory system education process. A 16-parameter model of the respiratory system simulated in the MATLAB/Simulink environment was set in the role of the tested patient. It has been linked to the control layer, developed in the LabVIEW environment, using the SIT library (Simulation Interface Toolkit). This layer...
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An application supporting the educational process of the respiratory system obstructive diseases detection
PublikacjaThe paper presents a description of functioning of a platform supporting the detection of obstructive diseases in the respiratory system education process. A 16-parameter model of the respiratory system simulated in the MATLAB/Simulink environment was set in the role of the tested patient. It has been linked to the control layer, developed in the LabVIEW environment, using the SIT library (Simulation Interface Toolkit). This layer...
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Automated anonymization of sensitive data on production unit
PublikacjaThe article presents an approach to data anonymization with the use of generally available tools. The focus is put on the practical aspects of using open-source tools in conjunction with programming libraries provided by suppliers of industrial control systems. This universal approach shows the possibilities of using various operating systems as a platform for process data anonymization. An additional advantage of the described...
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VUV photofragmentation of the six-membered heterocyclic molecules containing oxygen
PublikacjaCancer is a significant public health concern worldwide, which results in millions of deaths each year. The standard cure routine for cancer is surgery, and nowadays, radiotherapy or a hadrontherapy. Depending on the type of cancer, patients may undergo additional treatment, including targeted therapy. A combination of radio- or hadron-therapy with proper drug treatment can inhibit the proliferation of cancer cells and thus can...
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State of the art and prospects of methods for determination of lipophilicity of chemical compounds
PublikacjaLipophilicity of the compounds is useful to (i) explain their distribution in biological systems, which is different in plant and in animal organisms, (ii) predict the possible pathways of pollutant transport in the environment, and (iii) support drug discovery process and select optimal composition in terms of bioactivity and bioavailability. The lipophilic properties can be determined by two main approaches, experimental, which...
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Application of the near-infrared spectroscopy in the pharmaceutical technology
PublikacjaNear-infrared (NIR) spectroscopy is currently the fastest-growing and the most versatile analytical method not only in the pharmaceutical sciences but also in the industry. This review focuses on recent NIR applications in the pharmaceutical technology. This article covers monitoring, by NIR, of many manufacturing processes, such as granulation, mixing or drying, in order to determine the end-point of these processes. In this...
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Detection of some volatile degradation products released during photoexposition of ranitidine in a solid state
PublikacjaRanitidine (RAN) is on top of the list of prescribed drugs, due to its popularity as a selective H2-receptor antagonist, which efficiently decreases the amount of acid produced in the stomach. RAN is not stable both in a solid state and in a solution, which creates manufacturing problems, requires appropriate storage conditions, and results in a short drug shelf-life. The aim of this work was to study the emission of volatile...
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Application of vibrational spectroscopy, thermal analyses and X-Ray diffraction in the rapid evaluation of the stability in solid-state of ranitidine, famotidine and cimetidine
PublikacjaThis paper reports the study on applicability of Fourier transform infrared (FTIR), near-infrared (NIR) and Raman spectroscopy, differential scanning calorimetry (DSC) and X-ray diffraction (XRD) for the estimation of the chemical stability and photostability of histamine H2-receptor antagonist substances. Ranitidine hydrochloride (RAN), famotidine (FAM) and cimetidine (CIM) were tested and differences in sensitivity were measured...
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Monosubstituted hydrazone β-cyclodextrin derivatives for pH-sensitive complex formation with aromatic drugs
PublikacjaA new and convenient synthetic pathway was developed to produce monosubstituted cyclodextrins with high yields. Each of the β-cyclodextrin derivatives described in this work has an aromatic substituent connected with cyclodextrin core by a pH-sensitive hydrazone linker and a carbon chain. Carbon chains differ in lengths having one or three carbon atoms. The correlation between water solubility and linker length was determined using...
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Digitalizacja nie śpi! Czy w Bibliotece Politechniki Gdańskiej sprostamy wyzwaniom stawianym przez cyfrową humanistykę?
PublikacjaCelem artykułu jest przedstawienie działań Biblioteki Politechniki Gdańskiej w zakresie digitalizacji oraz udostępniania zasobów kultury i nauki na platformie Pomorskiej Biblioteki Cyfrowej. Podejmowane zadania zostały zestawione z ogłoszonymi w 2020 r. postulatami międzynarodowej organizacji DARIAH zajmującej się dostarczaniem społecznościom naukowym metod cyfrowych do tworzenia, łączenia i dzielenia się wiedzą.
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Current trends in analytical strategies for the determination of polybrominated diphenyl ethers (PBDEs) in samples with different matrix compositions – Part 2: New approaches to PBDEs determination
PublikacjaHerein, we review the latest technical solutions for polybrominated diphenyl ethers (PBDEs) determination in samples with different matrix compositions, largely focusing on gas chromatography but also presenting some liquid chromatography–based solutions. Moreover, we discuss the use of diverse sample injection techniques while considering the advantages and disadvantages of each injection system in the context of PBDEs analysis....
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Shoulder ultrasound in the diagnosis of the suprascapular neuropathy in athletes
PublikacjaPurpose: Shoulder pain and weakness are common symptoms in athletes who play sports connected with overhead throwing. Suprascapular neuropathy may be one of the reason of such signs.The aim of the study was to find out if ultrasound examination of the shoulder in athletes reveals signs of suprascapular neuropathy. Methods: This was a cross-sectional study in which 67 pro- fessional volleyball, handball and rugby players of polish...
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Nondestructive Optical Sensing of Flavonols and Chlorophyll in White Head Cabbage ( Brassica oleracea L. var. capitata subvar. alba ) Grown under Different Nitrogen Regimens
PublikacjaA multiparametric optical sensor was used to nondestructively estimate phytochemical compounds in white cabbage leaves directly in the field. An experimental site of 1980 white cabbages (Brassica oleracea L. var. capitata subvar. alba), under different nitrogen (N) treatments, was mapped by measuring leaf transmittance and chlorophyll fluorescence screening in one leaf/cabbage head. The provided indices of flavonols (FLAV) and...
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The extended version of restriction analysis approach for the examination of the ability of low-molecular-weight compounds to modify DNA in a cell-free system
PublikacjaOne of the primary requirements in toxicology is the assessment of ability of chemicals to induce DNA covalent modification. There are several well-established methods used for this purpose such as 32P-Postlabeling or HPLC-MS. However, all of these approaches have difficult to overcome limitations, which prevents their use in genotoxin screening. Here, we describe the simple protocol exploiting specificity of restriction enzymes...
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The Use of Liquid Crystal Thermography in Selected Technical and Medical Applications—Recent Development
PublikacjaThermochromic liquid crystals (TLC) and true-colour digital image processing have been successfully used in non-intrusive technical, industrial and biomedical studies and applications. Thin coatings of TLC at surfaces are utilized to obtain detailed temperature distributions and heat transfer rates for steady or transient processes. Liquid crystals also can be used to make the temperature and velocity fields in liquids visible...
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Determination of 3-MCPD and 2-MCPD esters in edible oils, fish oils and lipid fractions of margarines available on Polish market
Publikacja3-monochloropropane-1,2-diol (3-MCPD) and 2-monochloropropane-1,3-diol (2-MCPD) are intensively investigated food contaminants, which recently emerged as a serious problem within the discovery of high levels of their fatty acid esters in lipid samples. In order to monitor the concentrations of mentioned toxicants in edible oils and fats, several analytical methods have been developed so far. This paper presents the screening research...
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Lead-free bismuth-based perovskites coupled with g–C3N4: A machine learning based novel approach for visible light induced degradation of pollutants
PublikacjaThe use of metal halide perovskites in photocatalytic processes has been attempted because of their unique optical properties. In this work, for the first time, Pb-free Bi-based perovskites of the Cs3Bi2X9 type (X = Cl, Br, I, Cl/Br, Cl/I, Br/I) were synthesized and subjected to comprehensive morphological, structural, and surface analyses, and photocatalytic properties in the phenol degradation reaction were examined. Furthermore,...
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Radio programowalne - nowoczesna platforma dydaktyczna
PublikacjaPrzedstawiono technologię radia programowalnego jako nowoczesną platformę dydaktyczną. Zaproponowane podejście pozwala na efektywniejsze planowanie stanowisk laboratoryjnych. Umożliwia skrócenie czasu realizacji etapów związanych z projektowaniem, symulacją i testowaniem działania łącza radiowego. Pozwala również na elastyczną zmianę stanowisk laboratoryjnych zgodnie z dynamicznym rozwojem współczesnych systemów radiokomunikacyjnych.
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Intelligent Autonomous Robot Supporting Small Pets in Domestic Environment
PublikacjaIn this contribution, we present preliminary results of the student project aimed at the development of an intelligent autonomous robot supporting small pets in a domestic environment. The main task of this robot is to protect a freely moving small pets against accidental stepping on them by home residents. For this purpose, we have developed the mobile robot which follows a pet and makes an alarm signal when a human is approaching....
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Three-dimensional Web Geographic Information System using web-based technologies
PublikacjaWeb-based Geographic Information Systems offer a way of delivering geographic information to devices with small computational power, such as smartphones. In recent years, the rapid development of the Web Graphics Library (WebGL) made it possible to create rich interactive applications running inside a web browser and displaying three-dimensional objects using hardware acceleration. This paper presents a three-dimensional Web-GIS...
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Interactions with recognized objects
PublikacjaImplicit interaction combined with object recognition techniques opens a new possibility for gathering data and analyzing user behavior for activity and context recognition. The electronic eyewear platform, eGlasses, is being developed, as an integrated and autonomous system to provide interactions with smart environment. In this paper we present a method for the interactions with the recognized objects that can be used for electronic...
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Koncepcja środowiska umożliwiającego symulację działań obiektów militarnych.
PublikacjaPraca zawiera opis najbardziej popularnych platform symulacji walki robotów militarnych. Przeanalizowano ich główne wady i ograniczenia programowe oraz nieadekwatność odtworzenia rzeczywistych warunków i przebiegu walki. Na tym tle przedstawiono oryginalną koncepcję oraz założenia projektowe środowiska symulacji działań autonomicznych obiektów (robotów) militarnych. Proponowana platforma ma umożliwić:- porównanie jakości taktyk...
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Video Analytics-Based Algorithm for Monitoring Egress from Buildings
PublikacjaA concept and practical implementation of the algorithm for detecting of potentially dangerous situations of crowding in passages is presented. An example of such situation is a crush which may be caused by obstructed pedestrian pathway. Surveillance video camera signal analysis performed on line is employed in order to detect hold-ups near bottlenecks like doorways or staircases. The details of implemented algorithm which uses...
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Monitoring system of the road embankment
PublikacjaThe paper presents the monitoring system of the embankment supported on concrete columns and overlaid by a load transfer platform (LTP) with the embedded steel grid. This field investigation was to study the complex inter-action between the columns, the LTP layer, and steel reinforcement via full-scale in situ measurements during erection of the embankment. The study was focused on the behaviour of steel reinforcement and the behaviour...
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New approach to urban housing - Report of ISOCARP Young Planning Professionals Workshop, Gdynia School of Urbanizm, Aesop Urban Summer School
PublikacjaThe workshop was organized along with the INTERNATIONAL CONFERENCE LIVING IN THE CITY – PROBLEMS AND CHALLENGES OF SHAPING HOUSING POLICY which is hosted by the City of Gdynia Poland. It was conducted in frame of Young Planning Professionals Program and 7th AESOP uropean Urban Summer School but also as the new type of the activity for the Young Planners “Gdynia School of...
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DMI measurements impact on a position estimation with lack of GNSS signals during Mobile Mapping
PublikacjaNowadays, Mobile Laser Scanning is common in use in addition to geodesy measurements. The data which are provided by the system characterizes with high precision and flexibility. To precise mapping, the accuracy of the data should be maintained. In Poland, according to the minister’s dispositions, the accuracy of the data should not exceeded 10 cm. With fully operated system it is easy to uphold, but there is a situation when a...
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High-Speed Serial Embedded Deterministic Test for System-on-Chip Designs
PublikacjaThe paper presents a high-speed serial interface between external tester and Embedded Deterministic Test (EDT) compression logic hosted by SoC designs. With only a single bidirectional link, the system is capable of feeding distributed heterogeneous cores with hundreds of test channels. Moreover, it synergistically supports EDT bandwidth management to improve the overall test performance. A detailed study indicates a high potential...
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The complete list of two-dimensional number-conserving ternary cellular automata
Dane BadawczeThis dataset contains a complete list of all 1327 two-dimensional number-conserving cellular automata with the state set {0,1,2} (the so-called ternary cellular automata) based on adjacent cells only, i.e. with the von Neumann neighborhood. The detailed definitions and the method of enumerating are given in the paper:
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Podejście nauczycieli akademickich do rozwoju narzędzi e-learningowych na wyższych uczelniach technicznych
PublikacjaPlatforma edukacyjna na uczelni wyższej stała się już standardem. Jest wyznacznikiem nowoczesno- ści danej uczelni. Wpływa na jej konkurencyjność. Mimo to, istnieje przekonanie że środowisko nauczycieli akademickich nie jest gotowe do akceptacji nowych środków nauczania. Postanowiono zbadać ten problem. Artykuł zawiera odpowiedź na pytanie jaki stosunek do metod e-nauczania panuje wśród nauczycieli akademickich, nie posiadających...
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Wykorzystanie mediów społecznościowych do promocji otwartości w badaniach naukowych na przykładzie Biblioteki Politechniki Gdańskiej
PublikacjaMedia społecznościowe są jednym ze sposobów na skuteczną promocję zasobów oraz usług bibliotecznych w obecnym świecie cyfrowym. Stanowią również niedocenianą możliwość komunikacji pomiędzy naukowcami, bibliotekarzami a czytelnikami. Biblioteka akademicka może aktywnie angażować się w proces upowszechniania dorobku naukowego uczelni, podejmując w tym celu różnorakie działania marketingowe, wykorzystując takie serwisy jak: Facebook,...
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Tomasz Deręgowski dr inż.
OsobyTomasz Deręgowski jest adiunktem w Katedrze Informatyki w Zarządzaniu na Wydziale Zarządzania i Ekonomii Politechniki Gdańskiej, oraz kierownikiem Departamentu Inżynierii Platform Danych, pracującego nad rozwiązaniami Big Data, uczenia maszynowego i inżynierii danych w Nordea Bank AB - największej Skandynawskiej instytucji finansowej. Wcześniej pracował przez 15 lat w branży IT jako programista, lider zespołu, kierownik programu...
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Comparing the permeability of human and porcine small intestinal mucus for particle transport studies
PublikacjaThe gastrointestinal mucus layer represents the last barrier between ingested food or orally administered pharmaceuticals and the mucosal epithelium. This complex gel structure plays an important role in the process of small intestinal absorption. It provides protection against hazardous particles such as bacteria but allows the passage of nutrients and drug molecules towards the intestinal epithelium. In scientific research, mucus...
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The Efficacious Benefit of 25-Hydroxy Vitamin D to Prevent COVID-19: An In-Silico Study Targeting SARS-CoV-2 Spike Protein
PublikacjaThe environment has rapidly looked at proven specialist task forces in the aftermath of the COVID-19 pandemic to build public health policies and measures to mitigate the effects of emerging coronaviruses. According to the researchers, taking 10 μg of 25-hydroxy vitamin D daily is recommended to keep us safe. There have been several studies recently indicating that there is a reduced risk of contracting Coronavirus by 25-hydroxy...
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Glucosinolates from lepidium peruvianum as potential antiamnestic drugs
PublikacjaLepidium peruvianum (maca) (Brassicaceae) is a naturally occurring plant mainly in the high Andes of Peru. In recent years, it has been intensively researched in terms of its influence on various diseases and towards health improvement. Alzheimer’s disease is an incurable disease that most often affects adults over the age of 60. As since 2003 the US Food and Drug Administration (FDA) did not approve any new drug for Alzheimer’s...
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Tryton Supercomputer Capabilities for Analysis of Massive Data Streams
PublikacjaThe recently deployed supercomputer Tryton, located in the Academic Computer Center of Gdansk University of Technology, provides great means for massive parallel processing. Moreover, the status of the Center as one of the main network nodes in the PIONIER network enables the fast and reliable transfer of data produced by miscellaneous devices scattered in the area of the whole country. The typical examples of such data are streams...
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Acceleration of the DGF-FDTD method on GPU using the CUDA technology
PublikacjaWe present a parallel implementation of the discrete Green's function formulation of the finite-difference time-domain (DGF-FDTD) method on a graphics processing unit (GPU). The compute unified device architecture (CUDA) parallel computing platform is applied in the developed implementation. For the sake of example, arrays of Yagi-Uda antennas were simulated with the use of DGF-FDTD on GPU. The efficiency of parallel computations...
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Using EO satellite data in Safe City and Coastal Zone web-GIS
PublikacjaThe paper presents a novel design of a web-based Safe City & Coastal Zone GIS (SCCZ-GIS) which integrates data acquired from different remote sensing and geospatial data sources for monitoring the security of the coastal zone, its inhabitants and Critical Infrastructure. The system utilizes several innovative technologies and directly co-operates with different remote sensing data sources and services, like a satellite ground station...
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Parallel Background Subtraction in Video Streams Using OpenCL on GPU Platforms
PublikacjaImplementation of the background subtraction algorithm using OpenCL platform is presented. The algorithm processes live stream of video frames from the surveillance camera in on-line mode. Processing is performed using a host machine and a parallel computing device. The work focuses on optimizing an OpenCL algorithm implementation for GPU devices by taking into account specific features of the GPU architecture, such as memory access,...
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Wroclaw University of Technology Knowledge Repository - project objectives
PublikacjaKnowledge Repository is a project created in the Library and Scientific Information Centre of Wroclaw University of Technology (WrUT). Its main task will be collecting, sharing, and promoting scientific publications of researchers, postgraduates and students of WrUT. It will be also used for bibliometric analysis and reporting research output of WrUT scientific community.Knowledge Repository will closely cooperate with other databases...
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Monolithic vs. Microservice Architecture: A Performance and Scalability Evaluation
PublikacjaContext. Since its proclamation in 2012, microservices-based architecture has gained widespread popularity due to its advantages, such as improved availability, fault tolerance, and horizontal scalability, as well as greater software development agility. Motivation. Yet, refactoring a monolith to microservices by smaller businesses and expecting that the migration will bring benefits similar to those reported by top global companies,...
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REVIEW OF CURRENT RESEARCH ON CHITOSAN AS A RAW MATERIAL IN THREE-DIMENSIONAL PRINTING TECHNOLOGY IN BIOMEDICAL APPLICATIONS
PublikacjaThree-dimensional (3D) biomaterial manufacturing strategies show an extraordinary driving force for the development of innovative solutions in the biomedical sector, including drug delivery systems, disease modelling and tissue and organ engineering. Due to its remarkable and promising biological and structural properties, chitosan has been widely studied for decades in several potential applications in the biomedical field. However,...
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Recent progress in the development of steroid sulfatase inhibitors – examples of the novel and most promising compounds from the last decade
PublikacjaThe purpose of this review article is to provide an overview of recent achievements in the synthesis of novel steroid sulfatase (STS) inhibitors. STS is a crucial enzyme in the biosynthesis of active hormones (including estrogens and androgens) and, therefore, represents an extremely attractive molecular target for the development of hormone-dependent cancer therapies. The inhibition of STS may effectively reduce the availability...
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Computational methods for calculation of binding free energy for ligand-receptor complexes
PublikacjaAccurate description of the molecular complexes energetic influence is required for understanding of many biological functions carried out by proteins. Therefore, estimation of binding free energy for ligand-receptor complexes is of highest importance for structure-based ligand design and drug discovery approaches.Experimental methods of determination of difference in Gibbs'es free energy have many limitations. Thus, computational...
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Radiosensitization of DNA in presence of Pt(II)-based compounds
PublikacjaX-ray irradiation of plasmid DNA in presence of platinum (II)-based compounds was carried out in order to assess the radiosensitization capabilities of these drugs. In present investigations pBR322 plasmid DNA was used to monitor the effectiveness of chosen compounds in inducing strand breaks. Samples were incubated in the presence of potential radiosensitisers: platinum (II) bromide and cis-diamminedibromoplatinum (II). The results...
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Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics – synthesis and properties
PublikacjaGlucosamine-6-phosphate synthase (GlcN-6-P synthase) is known as a promising target for antimicrobial agents and antidiabetics. Several compounds of natural or synthetic origin have been identified as inhibitors of this enzyme. This set comprises highly selective L-glutamine, amino sugar phosphate or transition state intermediate cis-enolamine analogues. Relatively low antimicrobial activity of these inhibitors, poorly penetrating...
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Synthesis and biological evaluation of novel analogues of batracylin with synthetic amino acids and adenosine: an unexpected effect on centromere segregation in tumor cells through a dual inhibition of topoisomerase IIa and Aurora B
PublikacjaIn the search for new anticancer agents we designed and synthesized batracylin derivatives with linking synthetic amino acid side chains of different lengths and adenosine. Unexpectedly, we have found that in water and the culture media adenosine–amino acid–BAT conjugates form supramolecular structures and this prevents these compounds from entering cells. Consequently, these compounds exerted no biological activity when tested...
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Abuse or contamination? Ratio determination of clenbuterol enantiomers to distinguish between doping use and meat contamination
PublikacjaClenbuterol has been detected in urine of several athletes during routine doping control in the past years. Athletes claimed that the clenbuterol was ingested by eating contaminated meat. Providing analytical prove for this claim is difficult. clenbuterol consists of two enantiomers, R(-) and S(+)-clenbuterol. Currently available human and veterinary preparations were found to consist of a racemic mixture of both enantiomers. When...
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Detoxification of the tricyclic antidepressant opipramol and its analog – IS-noh by UGT enzymes before and after activation by phase I enzymes in rat liver microsomes
PublikacjaThe present studies were carried out to evaluate the simultaneous one-pot metabolism of opipramol (IS-opi) and analog (IS-noh) by phase I and phase II enzymes present in rat liver microsomes (RLM) as an alternative to separate testing with recombinant enzymes. This approach allows for more time-saving and cost-effective screening of the metabolism of newly discovered drugs. We also considered that the lack of results for phase...
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Distinguishing of cocrystals from simple eutectic mixtures: phenolic acids as potential pharmaceutical coformers
PublikacjaThe multiparameter model comprising 1D and 2D QSPR/QSAR descriptors was proposed and validated for phenolic acid binary systems. This approach is based on the optimization of regression coefficients for maximization of the percentage of true positives in the pool of systems comprising either simple binary eutectics or cocrystals. The training set consisted of 58 eutectics and 168 cocrystals. The solid dispersions collection used...
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Identification and molecular modeling of a novel lipase from an Antarctic soil metagenomic library.
PublikacjaIn this work, we present the construction of a metagenomic library in Escherichia coli using pUC19 vector and environmental DNA directly isolated from Antarctic topsoil and screened for lipolytic enzymes. The screening on agar supplemented with olive oil and rhodamine B revealed one clone with lipolytic activity (Lip1) out of 11,000 E. coli clones. This clone harbored a plasmid, pLip1, which has an insert of 4722 bp that has been...
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Fast EM-Driven Nature-Inspired Optimization of Antenna Input Characteristics Using Response Features and Variable-Resolution Simulation Models
PublikacjaUtilization of optimization technique is a must in the design of contemporary antenna systems. Often, global search methods are necessary, which are associated with high computational costs when conducted at the level of full-wave electromagnetic (EM) models. In this study, we introduce an innovative method for globally optimizing reflection responses of multi-band antennas. Our approach uses surrogates constructed based on response...
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Diploma Seminar (PG_00042079) D&PE 2023 Winter Semester
Kursy OnlinePresentation of the topic, the main issues of the diploma thesis and the tasks of the diploma thesis completed so far. The topic of the presentation is the same as the topic of the diploma thesis. Presentation of a literature analysis, including, among others: 10 papers from journals related to the topic of the work. Submitting to e-learning platform: - pdf version of the presentation - printed description (max 4 pages) a of the...
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Władza platform.Za fasadą Google, Facebooka i Spotify
PublikacjaTo książka o władzy platform Facebooka i Google, o kontrolowaniu człowieka, grup społecznych, a nawet państw. O „magii” uzależniania ludzi, celebracji osobliwych mitów, kulcie porażki, mirażach bogactwa, kreatywności i kariery. To książka o algorytmizacji codziennego życia, feudalnych stosunkach na platformach, ich niewolnikach i menedżerach pokutnikach. O zarządzaniu antykonkurencyjnymi platformami, o „strefach zabójstw” rynkowych...
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Toolchain Modeling: Comprehensive Engineering Plans for Industry 4.0
PublikacjaThe fourth industrial revolution (Industry 4.0) elevates the complexity and autonomy of industrial systems and engineering environments to levels not seen before. The novel challenges involve not only the software running on the partaking autonomous devices, but also architectural considerations and the technological infrastructure around the entire engineering process. In this paper, complementing the trends in industrial systems...
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Rigid finite elements and multibody modeling in analyses of a robot shaped elastic/plastic deformations of a beam
PublikacjaDynamics analysis of a system composed of a parallel manipulator and of an elastic beam is presented in the paper. Classic 3RRR parallel manipulator is considered and used to deform the beam. Elasto-plastic deformations are investigated. Rigid-finite-elements technique is employed to deal with dynamics of the beam. A multibody structure is associated with the introduced hybrid system in order to model its dynamics. Idea of the...
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The Influence of External Additional Loading on the Muscle Activity and Ground Reaction Forces during Gait
PublikacjaAsymmetrical external loading acting on the usculoskeletal system is generally considered unhealthy. Despite this knowledge, carrying loads in an asymmetrical manner like carrying on one shoulder, with one hand, or on the strap across the torso is a common practice. This study is aimed at presenting the effects of the mentioned load carrying methods on muscle activity assessed by using thermal field and ground reaction forces....
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Perspectives of Telematics Implementation in Tri-City Transport Systems Management and Planning
PublikacjaIn 2010 the City of Gdynia applied for match funding the project ''Implementation of the Integrated Traffic Management System TRISTAR in Tri-City" under the Operational Programme Infrastructure and Environment. This year the project has been placed on a list approved by the Ministry of Infrastructure. Tri-City proceeds with a tender for the implementation of the system. The project will be implemented in key elements are included...