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Search results for: IMPURITIES IN PHARMACEUTICAL PRODUCTS
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Stability and phase transition investigation of olanzapine polymorphs
PublicationWe use electrical embedded-fragment QM method with both DFT/ωB97XD/6-31G* and MP2/6-31G* to investigate the phase transformations of olanzapine. Gibbs free energy calculations predict that form I is always the most stable structure and form II is the least stable one, while form IV is more stable than form III below about 200 K but less stable above this temperature, implying a polymorphic phase transformation. This may account...
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Determination of Toxicological Parameters of Selected Bioactive Organic Chemicals Using the Ostracodtoxkit FTM
PublicationAssessment of the impact of pharmaceutical residues on living organisms is very complex subject. Apart from taking into account the toxicity of individual compounds also their presence in mixtures should be taken into account. In this work, attempts were made to assess the ecotoxicity of biologically active substances (with 50 % effective concentration (EC50) values growing from fluoxetine (EC50 = 4.431 nM) >> gemfibrozil ≈ 17α-ethinylestradiol...
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Solubilization of keratins and functional properties of their isolates and hydrolysates
PublicationThe keratinous wastes of the textile industry and poultry slaughterhouses may be used as sources of soluble keratins or hydrolysates. This review presents methods for processing raw keratin-based materials into bioproducts with functional and bioactive properties suitable for biomedical, cosmetic, food, and agricultural applications. Soluble keratin can be obtained by thermal treatment in some organic solvents, reduction, or oxidation...
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Enhancing Product Innovation Through Smart Innovation Engineering System
PublicationThis paper illustrates the idea of Smart Innovation Engineering (SIE) System that helps in carrying the process of product innovation. The SIE system collects the experiential knowledge from the formal decisional events. This experiential knowledge is collected from the set of similar products having some common functions and features. Due to the fact that SIE system collects, captures and reuses the experiential knowledge of all...
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Productivity effects of trade in natural resources—comparison with mechanisms of technological specialisation
PublicationThis paper compares two alternative growth paths, assessing the effects on productivity of specialisation in natural resources (NR) and in technologically advanced products. The empirical analysis exploits product-level export data for 109 developing and 51 developed economies over the period 1996–2018. We document two distinct types of specialisation, based on exports either of natural resources or of technological products, and...
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Report for the Short Term Scientific Mission within COST Action FP1101: development of the in-field sensor for estimation of fracture toughness and shear strength by measuring cutting forces
PublicationKnowledge on the fracture properties of materials is essential to assure structural integrity and proper design of mechanical connections in timber constructions. Measurement of this property is, however, a very challenging task. The linear fracture mechanics is usually used for its assessment assisted with experimental data acquired by means of various techniques, usually of destructive nature. The cutting force is an energetic...
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Two-dimensional gas chromatography – principles and application in fruits analysis
PublicationTwo-dimensional gas chromatography is a rapidly developing analytical technique. One of the major uses of this technique is its use for food analysis. The paper presents the principle of operation and history of this analytical technique. The specification of the two-dimensional gas chromatography technique has been discussed. The principles of separation of ingredients and application of the method, particularly in the analysis...
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Photolytic and Photocatalytic Recreational Water Treatment
PublicationDisinfection is one of the most important steps during recreational water treatment. Nevertheless, disinfection by-products are formed by conventional disinfectants, which pose several health threats. The concentration of disinfection by-products can be decreased by photolytic and photocatalytic treatment. Medium-pressure mercury lamp, UV-LEDs and solar irradiation were investigated and evaluated considering emitted wavelength,...
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The content of conjugated linoleic acid and vaccenic acid in the breast milk of women from Gdansk and the surrounding district, as well as in, infant formulas and follow-up formulas. Nutritional recommendation for nursing women
PublicationFatty acids are some of the most important components of human milk. Polyunsaturated fatty acids (PUFAs) are essential nutrients required for the optimal growth and development of infants, especially the central nervous system, brain and retina. AIM: To determine the conjugated linolenic acid (CLA) and vaccenic acid (VA) content of human breast milk from mothers consuming different diets, and to compare the results with CLA and...
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More than just a beer – Brewers' spent grain, spent hops, and spent yeast as potential functional fillers for polymer composites
PublicationBeer is among the most popular beverages in the world, with the production distributed uniformly between the biggest continents, so the utilization of brewing by-products is essential on a global scale. Among their potential recipients, the plastics industry offers extensive range of potential products. Herein, the presented study investigated the application of currently underutilized solid brewing by-products (brewers' spent...
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Masowe wymieranie pszczół – problem nie tylko pszczelarzy
PublicationPestycydy to bardzo liczna grupa różnorodnych związków chemicznych stosowanych w rolnictwie. Ze względu na swoją trwałość gromadzą się w różnych elementach środowiska i mogą występować w obszarze, na którym nigdy nie zostały użyte. Zachodzi także proces ich bioakumulacji w tkankach oraz narządach zwierząt i roślin. Stosowane w rolnictwie środki ochrony roślin (szczególnie w okresie wzmożonych zabiegów agrotechnicznych wiosną...
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Synthesis and reactivity of O-acyl selenophosphates
PublicationThe synthesis of several new O-acyl selenophosphates were investigated. The stability and reactivity of the products were studied and related to their structure.
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Modern solutions in the field of microextraction using liquid as a medium of extraction
PublicationThe monitoring of compounds present in samples at trace/ultra-trace level usually requires a preliminary step of isolation and/or enrichment of analytes. Against, sample preparation is considered as crucial part of whole analytical procedures, in particular in samples characterized by complex matrices composition. Several new miniaturized extraction techniques is introduced and extensively applied to different type of samples....
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Monosubstituted hydrazone β-cyclodextrin derivatives for pH-sensitive complex formation with aromatic drugs
PublicationA new and convenient synthetic pathway was developed to produce monosubstituted cyclodextrins with high yields. Each of the β-cyclodextrin derivatives described in this work has an aromatic substituent connected with cyclodextrin core by a pH-sensitive hydrazone linker and a carbon chain. Carbon chains differ in lengths having one or three carbon atoms. The correlation between water solubility and linker length was determined using...
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Modern trends in solid phase extraction: New sorbent media
PublicationBased on the recently published literature, this review provides an update of the most important features and application of formats and devices employed in solid phase extraction (SPE). Special attention was paid on new trapping media proposed in SPE prior the chromatography analysis, based on the use of nanostructured materials, including carbon nanomaterials, electrospun nanofibers, dendrimes and magnetic nanoparticles, molecular...
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Smart Innovation Engineering (SIE): Experience-Based Product Innovation System for Industry 4.0
PublicationThis paper presents a semi-automatic system capable of facilitating product innovation process. This system, known as Smart Innovation Engineering (SIE) system, helps in decision-making by using the explicit knowledge of formal decision events. The SIE system carries the promise to support the innovation processes of manufactured products in a quick and efficient way. It stores and reuses the past decisional events or sets of experiences...
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Modeling process of planning finished product sales volumes at industrial enterprises in modern economic conditions
PublicationThis article presents improving the existing system of planning finished products sales volumes. The influencing factors of the sales volumes in modern economic conditions have been determined: falling world oil prices, the reduction of pipe consumption in the domestic market, the global pandemic. The algorithm of planning finished products sales volumes has been constructed. Calculations based on the Holt forecasting method has...
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A New Approach to Chemical Recycling of Polyamide 6.6 and Synthesis of Polyurethanes with Recovered Intermediates
PublicationA new efficient method for the chemical decomposition of polyamide 6.6 by the glycolysis and amino-glycolysis processes was proposed. The glycolysis was conducted using the mass excess of ethylene glycol (EG) as a decomposing agent in the presence of a catalyst. Also, a mixture of EG and triethylenetetramine was used as another decomposing agent in the amino- glycolysis process. The described process of decomposition did not...
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SSE PLATFORM APPLICATION TO EXTEND OPERATIONABILITY OF WEB-GIS BASED MARINE SERVICES OF AN HRPT-METOP SATELLITE GROUND STATION
PublicationEarth Observation (EO) products are widely used by geospatial society. Over the last years a number of new applications of satellite imagery were proposed. This led to an increased interest in EO products, not only from researchers but also from companies and individuals. The authors constitute the essential part of the team that created the marine, web-GIS system - SafeCity GIS - for dissemination of data obtained from a 1.5 metre...
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METHOD TO EXTEND OPERATIONABILITY OF WEB-GIS BASED MARINE SERVICES USING SSE PLATFORM
PublicationEarth Observation (EO) products are widely used by geospatial society. Over the last years a number of new applications of satellite imagery were proposed. This led to an increased interest in EO products, not only from researchers but also from companies and individuals. The authors constitute the essential part of the team that created the marine, web-GIS system - SafeCity GIS - for dissemination of data obtained from a 1.5...
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Honey as an indicator of heavy metals in the environment
PublicationHoney bees collect nectar, pollen and honeydew to produce bee products. One of them is honey, which due to chemical composition and properties is considered by human as a valuable food product. When honey bees collect substrates to produce honey they can bring contaminants to the hive. The presence of xenobiotics in bee products may lower their quality and devalue their properties, and also endanger human health. Many scientists...
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Fabrication and Characterization of Green Polyurethane Foams with Enhanced Vibration Damping Capability
PublicationOver the past decades, there has been an intensive development of the technologies and innovations aimed at increasing the quality of life. This development largely concerns the comfort of use of everyday products that, among others, are products of the automotive, construction, or furniture industries. Considering the increase in the comfort of using products such as cars, houses, and flats, one of the comfort features of their...
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Corrosivity of environment and the current state of the steel elements at the former Auschwitz concentration camp
PublicationThe objective of this study was to assess corrosivity of the atmospheric environment in the former Auschwitz I and Auschwitz II-Birkenau concentration and extermination camp, and to identify the protective properties of existing corrosion products in order to estimate the actual corrosion rate of original steel elements located there. The current atmospheric corrosivity of the former Auschwitz camp, specified during one year of exposure...
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Investigation of the Dynamism of Nanosized SOA Particle Formation in Indoor Air by a Scanning Mobility Particle Sizer and Proton-Transfer-Reaction Mass Spectrometry
PublicationTerpenes are VOCs of particular importance, since they are emitted from a wide range of indoor sources and are considered to be precursors of Secondary Organic Aerosol (SOA) formation. It has been proven that SOA particles, especially nanosized ones, pose a threat to human health. In this research, experiments with the application of an environmental chamber and real-time measurement techniques were carried out to investigate in...
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Assessment of unusual failure in crankshaft of heavy-duty truck engine
PublicationThe unusual premature failure of a heavy-duty truck engine crankshaft has been the subject of a rigorous study, and this manuscript describes it in detail. The failure was happened to begin with the growth of the crack from the surface defects, in the form of the clusters of non-metallic inclusions, in the lubrication hole zone of the first main journal, which was the stress concentration zone. A series of experiments including...
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A Novel Method for the Deblurring of Photogrammetric Images Using Conditional Generative Adversarial Networks
PublicationThe visual data acquisition from small unmanned aerial vehicles (UAVs) may encounter a situation in which blur appears on the images. Image blurring caused by camera motion during exposure significantly impacts the images interpretation quality and consequently the quality of photogrammetric products. On blurred images, it is difficult to visually locate ground control points, and the number of identified feature points decreases...
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Influence of β-cyclodextrin on coupling reactions of o-nitrobenzenediazonium salt with pyrrole
PublicationThe influence of -cyclodextrin on o-nitrobenzenediazonium salt coupling with pyrrolehas been studied analyzing the yield and products distribution.
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Reclaiming ground tire rubber at low temperatures: benefits and limitations
PublicationLower extrusion temperatures during rubber reclamation lead to a reduction in toxic degradation products and improve the mechanical properties of vulcanizates, at the expense of reduced processability.
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Recent advances on magnetic carbon-related materials in advanced oxidation processes of emerging pollutants degradation
PublicationRecently, carbon-related materials have been proposed to improve the charge separation of the photogenerated carriers in the semiconductor matrices’ and surface properties. Carbon-related materials may act as co-catalysts, enhancing the pollutants adsorption on the surface, improving the charge carriers separation and photocatalyst stability and providing more active centres for photocatalytic reactions. This review summarizes...
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Mobile chromatographs and spectrometers for the analysis of chemical warfare agents
PublicationThis article describes the technological state of readiness regarding mobile chromatographs and spectrometers and their appiicability for the analysis of chemical warfare agents (CWAs), degradation products, simulants, and precursors.
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Experience marketing in the service of the “secular religion” of big tech
PublicationThe article proposes an interpretation of the meaning of experience marketing as a tool in the process of sacralisation of products, and in a broader context – the so-called secular religion accompanying some contemporary big tech organizations. The article is of theoretical nature and the authors have intended to explain how big tech corporations, in line with the concept of experience marketing (digital platforms, in particular),...
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THE MELT FLOWABILITY AND TENSILE PERFORMANCE OF POLY (-CAPROLACTONE)/BREWERS’ SPENT GRAIN COMPOSITES AS A FUNCTION OF FILLER MODIFICATION
PublicationNowadays, it is essential to reduce the environmental impact of products and technologies. Such an approach should be highlighted in all research activities. In the case of polymer composites, it can be realized by introducing by-products or waste materials as fillers. An auspicious example of such material is the brewers’ spent grain, the major byproduct of the beer production. Its chemical composition, relatively similar to conventional...
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Singlet oxygen in the removal of organic pollutants: An updated review on the degradation pathways based on mass spectrometry and DFT calculations
PublicationThe degradation of pollutants by a non-radical pathway involving singlet oxygen (1O2) is highly relevant in advanced oxidation processes. Photosensitizers, modified photocatalysts, and activated persulfates can generate highly selective 1O2 in the medium. The selective reaction of 1O2 with organic pollutants results in the evolution of different intermediate products. While these products can be identified using mass spectrometry...
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Environmentally Oriented Models and Methods for the Evaluation of Drug x Drug Interaction Effects
PublicationThis detailed review compares known and widely used methods for drug interaction estimation, some of which now have historical significance. Pharmaceutical application has been noted as far back as several thousand years ago. Relatively late in the 20th century, however, researchers became aware that their fate and metabolism, which still remain a great challenge for environmental analysts and risk assessors. For the patient’s...
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The effect of morphology and crystalline structure of Mo/MoO3 layers on photocatalytic degradation of water organic pollutants
PublicationMolybdenum oxide layers were formed by anodization of the Mo metallic foil in a water/ethylene glycol-based electrolyte containing fluoride ions. The as-prepared, amorphous samples were annealed in air at different temperatures in a range from 100 �C to 700 �C. The crystal phase and morphology of anodized and annealed MoO3 layers were investigated using X-ray diffraction, Raman spectroscopy, and scanning electron microscopy. The...
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Analytical procedures for quality control of pharmaceuticals in terms of residual solvents content: Challenges and recent developments
PublicationResidual solvents play an important role in the synthesis of drugs and in product formulations. In addition, they pose a serious problem, that is toxicity, as many of them exhibit toxic or environmentally hazardous properties. Therefore, constant monitoring of quality control is needed. In this study, we present an overview of regulatory and general methods described by various pharmacopoeias. Then, the most commonly used methodologies...
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Nanoparticles: Synthesis, characteristics, and applications in analytical and other sciences
PublicationNanoparticles (NPs) are widely employed in different research areas, ranging from analytical chemistry and environmental science to medicine, the agriculture and pharmaceutical industry. This is mainly due to the unique characteristics of NPs and the novelty they introduce in such applications. In analytical chemistry, the role of NPs can differ depending on the nature of the steps involved in analytical process. NPs are probably...
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Geometric analogue of holographic reduced representation
PublicationHolographic reduced representations (HRRs) are distributed representations of cognitive structuresbased on superpositions of convolution-bound n-tuples. Restricting HRRs to n-tuples consisting of 1,one reinterprets the variable binding as a representation of the additive group of binary n-tupleswith addition modulo 2. Since convolutions are not defined for vectors, the HRRs cannot be directlyassociated with geometric structures....
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Membrane distillation assisting food production processes of thermally sensitive food liquid items: a review
PublicationPhysical separation technologies have become important tool for processing in the current food manufacturing industries, especially for the products containing bioactive compounds thanks to their health benefits in costumers. As for the processing of bioactive food ingredients implies the implementation of integrated systems oriented to their separation, fractionation, and recovery. In this field, membrane distillation (MD), which...
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The fast identification of explosives, natcotics and other chemicals carried on board of ships or transported in containers
PublicationThe fast identification of explosives, narcotics and other chemicals carried on board of ships or transported in containers to the harbors is an important problem of maritime security. Raman spectroscopy is an advanced technique used in state-of-the art laboratories for fast identification of chemicals. No sample preparation is required, and identification can be carried out through transparent packing, such as plastic or glass,...
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Analysis of volatile fraction of hybrid fruit pulp using Proton Transfer Reaction - Time-Of-Flight Mass Spectrometry
PublicationFruits and vegetables are important ingredients in human diet. Because of this, it is very important to know their exact composition and to control their quality. Based on the aroma of food products, it is possible to pre-evaluate their quality and freshness. The aim of this work was to characterize the volatile fraction of the hybrid fruit ‘sweetie’ using the modern analytical device PTR-TOFMS. Hybrid fruit samples are human-made...
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A method for the production of D-tagatose using a recombinant Pichia pastoris strain secreting beta-D-galactosidase from Arthrobacter chlorophenolicus and a recombinant L-arabinose isomerase from Arthrobacter sp. 22c
PublicationD-Tagatose is a natural monosaccharide which can be used as a low-calorie sugar substitute in food, beverages and pharmaceutical products. It is also currently being tested as an anti-diabetic and obesity control drug. D-Tagatose is a rare sugar, but it can be manufactured by the chemical or enzymatic isomerization of D-galactose obtained by a beta-D-galactosidase-catalyzed hydrolysis of milk sugar lactose and the separation of...
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Analysis of the influence of polystyrene microplastics and their derivatives on the DNA of human colon epithelial cells HT29 with the comet assay
PublicationWe have been using plastic for almost a century and nowadays a lot of them circulates as pollutants in the environment and still defragmenting to micro and nanoscale. The exposition through the food chain and its precise impact on human health is still not clear. In our study, we tested real food packaging after contact with food products and real thermoinsulation and environmental samples of polystyrene in different model liquids,...
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Comprehensive determination of flavouring additives and nicotine in e-cigarette refill solutions. Part II: Gas-chromatography–mass spectrometry analysis
PublicationFlavouring compounds are an essential part of e-liquid products for cigarettes. In general, they are regarded as safe for ingestion, but they may have unrecognized risks when they are inhaled. In some cases, manufactures do not currently abide by the Tobacco Products Directive (2014/40/EU) and do not declare the detailed contents of e-liquids on their labels. To help evaluate the health impact of flavouring substances, there is...
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The Corporate Museum: A New Type of Museum Created as a Component of Marketing Company
PublicationA new type of museum appeared – the corporate museum. The museum institution in this instance has been used as a new marketing device for building corporate identity strategies. Their inception is not based on the existing context of a place, but appears to be integrated with the corporate identity program, exposing the company’s values and philosophy. The corporate museums are thematic, commercial buildings, owned by a particular...
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Smoking: Traditional
PublicationSmoking, drying, and salting belong to the oldest methods of food preservation. Meat hung by the fire was preserved by a combination of drying and smoking. Often the raw material was first pickled in brine. In different regions of the world various procedures have been developed, best suited for treating meats and fish for specific purposes. Smoking extended the shelf life and imparted very desirable, new sensory properties to...
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Towards Safety Case Integration with Hazard Analysis for Medical Devices
PublicationSafety case is one of system safety lifecycle products and should be consistent with other lifecycle products like hazard analysis results. In this paper we present a method of safety case integration with hazard tables based on the use of parametrized argument patterns. We describe a hazard table metamodel, a safety argument pattern and a mechanism of pattern instantiation using a linking table which represents references to system...
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Thermoplastic elastomer filaments and their application In 3D printig
PublicationThe paper provides an overview on the materials used in the 3D printing technology (the Polish and foreign market) with a particular focus on flexible filaments and their possible application in the industry. There are described the techniques of 3D printing and modern filaments available on the market. There is observed the increase of interest in the production of products from filaments based on thermoplastic elastomers (TPE),...
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The effect of processing on the safety and nutritional value
PublicationAgricultural crops as well as animal food raw materials are usually somehow processed before being used by humans. Processing should make them more useful, increase their safety and nutritional value, extend the shelf life, and modify the sensory properties. However, changes and interactions of various compounds in the conditions of processing may generate products toxic or otherwise unsafe for the human organism. The food industry...
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Wybrane aspekty zachowań internautów a skuteczny proces komunikacji marketingowej
PublicationCelem artykułu jest przedstawienie sposobów pozyskiwania internetowych treści związanych z organizacjami lub produktami oraz dzielenia się nimi z innymi. W publikacji zwrócono uwagę na potrzebę zmiany postrzegania roli internautów w procesie komunikacji marketingowej. Ponadto, artykuł nawiązuje do koncepcji inbound marketing. Koncepcja ta dotyczy nie tylko przyciągania klientów do firmy i jej produktów. Chodzi w niej o by poprzez...