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The role of glucuronidation in drug resistance
PublicationThe final therapeutic effect of a drug candidate, which is directed to a specific molecular target strongly depends on its absorption, distribution, metabolism and excretion (ADME). The disruption of at least one element of ADME may result in serious drug resistance. In this work we described the role of one element of this resistance: phase II metabolism with UDP-glucuronosyltransferases (UGTs). UGT function is the transformation...
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Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.
PublicationThe acridinone derivates C-1305 and C-1311 are promising antitumor agents with high activity against several experimental cellular and tumor models and which are under evaluation in pre-clinical and early phase clinical trials. Recent evidence from our laboratories has indicated that both compounds were conjugated by several UGT isoforms with the most active being extrahepatic UGT1A10. The present studies were designed to test...
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Impact of selected parameters of the fermentation process of wine and wine itself on the biogenic amines content: Evaluation by application of chemometric tools
PublicationThe demand for safer foods has promoted more research into biogenic amines (BAs) over the past few years, however, there are still some questions that remain unanswered. Despite the fact that BAs are present in wine and can cause toxic effect to the body, a shared regulation limiting the amounts of BAs in wine is still lacking. A detailed understanding of their presence in wine is also important for the food trade sector. Therefore,...
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Influence of CeO2 and TiO2 Particles on Physicochemical Properties of Composite Nickel Coatings Electrodeposited at Ambient Temperature
PublicationThe Ni-TiO2 and Ni-CeO2 composite coatings with varying hydrophilic/hydrophobic characteristics were fabricated by the electrodeposition method from a tartrate electrolyte at ambient temperature. To meet the requirements of tight regulation by the European Chemicals Agency classifying H3BO3 as a substance of very high concern, Rochelle salt was utilized as a buffer solution instead. The novelty of this study was to implement a...
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Modal Analysis of a Steel Radial Gate Exposed to Different Water Levels
PublicationWith the increase in water retention needs and planned river regulation, it might be important to investigate the dynamic resistance of vulnerable elements of hydroelectric power plants, including steel water locks. The most frequent dynamic loads affecting hydroengineering structures in Poland include vibrations caused by heavy road and railway traffic, piling works and mining tremors. More destructive dynamic loads, including...
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Transcriptional activity of epigenetic remodeling genes declines in keratinocytes after in vitro expansion
PublicationPURPOSE: In vitro expansion is an invaluable method to obtain keratinocytes in amounts necessary for effective transplantation therapies. In vitro cell culturing provokes questions concerning potential epigenetic alterations occurring in expanded cells in the context of usefulness for transplantation and safety. The purpose of this study was to investigate as to whether keratinocyte expansion is associated with changes in the activity...
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Detection of Denatonium Benzoate (Bitrex) Remnants in Noncommercial Alcoholic Beverages by Raman Spectroscopy
PublicationIllegal alcoholic beverages are often introduced into market using cheap technical alcohol, which is contaminated by denatonium benzoate (Bitrex) of very small concentration. Bitrex is the most bitter chemical compound and has to be removed before alcohol consumption. The home-made methods utilize sodium hypochlorite to disintegrate particles of denatonium benzoate in alcohol and to remove bitter taste before trading. In this experimental...
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The evolving structure of Polish exports (1994-2010) - diversification of products and trade partners.
PublicationThis paper presents empirical evidence on the diversification process concerning Polish exports (1994–2010), compared to European and global samples of countries. It analyzes both the commodity structure of Polish trade and the geographical diversification of Poland’s trading partners. The analysis draws on highly disaggregated data on exports (HS 6 digit) and combines descriptive analysis with non-parametric, semi-parametric and...
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Rapid development of custom web application with ruby on rails framework on the example of group project system
PublicationTechnology industry labor market requires engineers with a good preparation for work with project's tasks and team cooperation skills. One of the way for achieve that abilities during technical university education are students group projects. Running of group projects at university brings new challenges, from recruitment of students with required skills for par-ticular project, to lack of industrial procedures and ready to use...
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Smartphone application supporting independent movement of the blind
PublicationImproving comfort of life of blind people is a problem of great importance. Neither a white canenor a guide dog, although both very useful, can be considered as a tool for achieving fullindependence in everyday movement around the city. On the market there are some navigation toolsinspired by car navigation systems, but they have many flaws, ranging from positioninginaccuracies to high prices. The authors present their own solution...
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Investor confidence and high financial literacy jointly shape investments in risky assets
PublicationHouseholds consistently invest less in equities and bonds than predicted by economic theory. We explain this from a behavioral economics perspective and distributional analysis using rich US survey microdata. We find that higher investor self-confidence in her financial abilities and financial literacy jointly increase the probability of investing in equities. Conditional on participation, confidence in the macroeconomy additionally...
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Global value chains and inward FDI: An empirical investigation of European firms
PublicationThis paper empirically investigates whether and how the level of GVC integration of a given market may explain the presence of foreign-owned firms. Using firm-level data from 28 European Union countries during the period 2008–2014, we provide evidence that a greater country-sector-level GVC participation, via both backward and forward linkages, exerts a positive effect on a firm's likelihood to receive FDI. These findings appear...
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Creating Hotel Services from a Perspective of Extraordinary Customer Experience
PublicationThis conceptual article aims to explore the process of providing hotel services in the context of requirements arising from the experience economy. Both the concept of experience marketing and the concept of customer experience management provided a theoretical framework for the discussion. Based on a review of literature and conclusions derived from hotel managers’ experiences, a research model is proposed, which may be of some...
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IMPLEMENTING THE QUALITY ASSURANCE SYSTEM AND ASSURING HEALTH SAFETY IN THE LIGHT OF INCREASING BREAD QUALITY
PublicationThe article presents rules, requirements, and norms for quality management and health safety assurance systems among small and medium bakeries. This group of businesses does not have the obligation of implementing or certifying specific systems. They are, however, implemented in order to increase the quality of the bread or reach a better market position. Also, the results of a 2022 study of 53 bakeries’ implementation of individual...
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Networking and Familiness as Factors Stimulating the Early Internationalization of High-Tech Firms
PublicationThe problem of the role and importance of time in the process of firm’s internationalization belongs to the mainstream of international business research, as is the problem of the key role of high-tech firms operating across borders. The main goal of the paper is to understand how selected factors determine early internationalization of high-tech firms in Poland as an emerging market. The theoretical framework of the article is...
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ESG investing during the Covid-19 crisis. Evidence from Central European Stock Exchanges
PublicationAs COVID-19 turned into a global pandemic, world markets gradually began to recover after initial dynamic declines. Restrictions, and their subsequent loosening, were, and are, not without significance for the financial markets. These particular circumstances provide a unique opportunity to contribute to the literature by focusing on the potential resilience of ESG (environmental, social and governance) investing in an era of crisis....
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Ecology In Tribology: Selected Problems of Eliminating Natural Oil-Based Lubricants from Machine Friction Couples
PublicationThe elimination of mineral oil-based lubricants from machines has multiple beneficial effects on the natural environment. Firstly – these lubricants are a direct threat to the environment in the event of leaks; secondly – their elimination reduces the demand for crude oil from which they are obtained. In addition, in many cases, e.g. when replacing traditional lubricants with water, friction losses in the bearings can also be reduced...
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Neuroeconomy and Neuromarketing: The Study of the Consumer Behaviour in the COVID-19 Context
PublicationTo address the study of consumer behavior in the post-COVID-19 era, the present Research Topic brings together a set of papers that attempt to study how different factors triggered by the pandemic have achieved a significant effect on consumers' behavioral intentions. These papers examine different subtopics related to food, health products, collaborative economy and, of course, neuroscience. Globally, the objectives of this special...
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Theoretical and Economic Evaluation of Low-Cost Deep Eutectic Solvents for Effective Biogas Upgrading to Bio-Methane
PublicationThis paper presents the theoretical screening of 23 low-cost deep eutectic solvents (DESs) as absorbents for effective removal of the main impurities from biogas streams using a conductor-like screening model for real solvents (COSMO-RS). Based on thermodynamic parameters, i.e., the activity coefficient, excess enthalpy, and Henry’s constant, two DESs composed of choline chloride: urea in a 1:2 molar ratio (ChCl:U 1:2), and choline...
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A nontargeted approach to determine the authenticity of Ginkgo biloba L. plant materials and dried leaf extracts by liquid chromatography-high-resolution mass spectrometry (LC-HRMS) and chemometrics
PublicationThe lack of stringent regulations regarding raw materials for herbal supplements used for medicinal purposes has been a constant challenge in the industry. Ginkgo biloba L. leaf extracts attract consumers because of the supposed positive effect on mental performance and memory. Supplements are produced using dried leaf materials and standardized leaf extracts such as EGb 761. Adulteration of Ginkgo biloba L. plants and extracts...
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FINANCIAL COMPARISON OF WESTERN BALKAN AND BALTIC SEA STATES USING THE CAMEL APPROACH
Publication• The aim - This article aims to compare the situation in the banking sectors of two regions, which due to their political and economic history have much in common. These are the Western Balkan States of Serbia, Croatia and Macedonia, and the Baltic Sea States of Lithuania, Estonia, and Latvia. • Methods - It presents three approaches to defining banking stability that can be found in the literature and carries out an initial...
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Potential applications of crude glycerol in polymer technology–Current state and perspectives
PublicationThe increasing use of bio-based fuels and fuel additives, among them biodiesel, causes significant surplus of crude glycerol on the market which creates new challenges in terms of its sustainable utilization. A lot of ways for the incorporation of this by-product into different branches of industry requires purification by expensive and complicated processes. Therefore, researchers are seeking for applications of untreated crude...
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Aiming at methods’ wider adoption: Applicability determinants and metrics
PublicationNumerous computer science methods and techniques have been proposed by the scientific community. However, depending on the domain, only their minor fraction has met wider adoption. This paper brings attention to the concept of applicability - the notion that is well acknowledged in the scientific field but have not been analysed with respect to determinants, metrics and systematisation. The primary objective of the study was to...
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Application of advanced spectroscopic methods in the assessment of the leachability degree of hazardous elements from the matrix of cellular concretea
PublicationDue to its structure, autoclaved cellular concrete exhibits good insulating properties with relatively high compressive strength values. It is increasingly used in construction because of its economic attractiveness. Autoclaved cellular concrete is mainly used in interior structure layers, and therefore its potential exposure to heavy metal leaching from the matrix may be related to the presence of a high pH medium from other materials...
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Modeling process of planning finished product sales volumes at industrial enterprises in modern economic conditions
PublicationThis article presents improving the existing system of planning finished products sales volumes. The influencing factors of the sales volumes in modern economic conditions have been determined: falling world oil prices, the reduction of pipe consumption in the domestic market, the global pandemic. The algorithm of planning finished products sales volumes has been constructed. Calculations based on the Holt forecasting method has...
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Featured based CAVE software factory
PublicationIn the paper we convey the lessons learned along the path we have gone through several years since establishing a room-sized CAVE installation at our university, from craft manufacturing and ad-hoc software reuse of VR software products to the robust feature driven software product line (SPL) implementing the Product Line Engineering (PLE) factory paradigm. With that we can serve all our departments and other entities from the...
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Stanisław Barański mgr inż.
PeopleStanisław Barański received BSc in 2019 and MSc in 2020 in informatics at Gdańsk University of Technology. Currently, he is a PhD candidate at the Department of Computer Architecture, Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology. His research interests include blockchains and cryptography, especially the issue of blockchain-based internet voting and mitigation of content poisoning...
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New methodology for determination cationic surfactants in liquid environmental samples
PublicationBecause of their specific physical and chemical properties (e.g. amphiphilicity, solubility in polar and nonpolar liquids, ability to form micelles, adsorption at phase boundaries, low toxicity) surfactants (surface-active compounds) are widely applied in industry and in the household. As their applications are on a very large scale, it has become necessary to acquire a more detailed understanding of their environmental fate. Mainly,...
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China’s international trade and global value chains under One-Belt One-Road initiative
PublicationResearch background: After China acceded to the WTO in 2001, its foreign trade has expanded rapidly to be the largest share in the world. However, China's economic development changing from high-speed growth to medium high-speed growth in recent years. At the same time, the increase in labour cost and overcapacity also hinder China’s international trade. In order to solve these challenges and strengthening ties...
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C2 NIWA Community-Segmentation Criteria and Building Brand Associations on the Example of a Selected Target Group
PublicationEvery organization which offers products or services wishes to communicate with their customers in the most effective way. This kind of communication is based on proper selection of target groups, which are extracted in the process of market segmentation. That is way it is very important to ask the question to whom the message is to be directed and what kind of message we want to give. This article describes the selection criteria...
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Analiza SWOT i analiza 5 sił Portera dla rynku podstawowej opieki medycznej na obszarze miasta Gdańska
PublicationIn recent years we have seen the dynamic development of medical services sector inPoland. Private health centres focus on aggressive development strategy. The role of primaryhealth care facilities, which provide services financed from public funds, declined. The purpose of article is to describe medical services market in Gdańsk, especially in Gdańsk-South district. Itincludes demographics, the number and characteristics...
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Challenges for universities in the face of the knowledge-based economy - Directions for higher education institutions in the Baltic Sea Region
PublicationThe aim of this paper is to present new challenges that are faced by universities in the knowledge-based economy. There are several phenomena that can presently be observed like the need for life-long learning or interdisciplinary approach, and universities should prepare their graduates for those challenges. One of the crucial questions that universities need to ask is how to teach and what to teach. Knowledge becomes obsolete...
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Challenges for universities in the face of knowledge-based economy - directions for higher education institutions in the Baltic Sea Region
PublicationThe aim of this paper is to present new challenges that are faced by universities in the knowledge-based economy. There are several phenomena that can presently be observed like the need for life-long learning or interdisciplinary approach, and universities should prepare their graduates for those challenges. One of the crucial questions that universities need to ask is how to teach and what to teach. Knowledge becomes obsolete...
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New skills for architects: 3D scanning for an immersive experience in architectural education
PublicationThe authors of this article explore the integration of remote sensing techniques, specifically laser scanning and photogrammetry, as well as immersive visualisation via different methods applied to architectural design processes, and its potential impact on the professional development of future architects. The study demonstrates the value of extending the architectural design process into the interdisciplinary field of geomatics...
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The Influence of LED Lighting Sources on the Nature of Power Factor
PublicationThis article presents measurements of electric power absorbed by a newly built facility for office and scientific research activities. These measurements highlighted the need for compensation of capacitive reactive power—not predicted by the designer—due to the vast use of LED lighting in the facility. The article also describes a reactive power compensation system, designed on the basis of the above-mentioned measurements, and...
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Overcoming gender bias in the digital economy. Empirical evidence for European countries
PublicationThis study aims to contribute to understanding the gender biases that emerge in the digital technology-related field. More specifically we concentrate on examining whether gender gaps are diminishing or are persistent in terms of women’s enrollment in technology-related programs at the tertiary level of education and for female STEM graduates. Next, this evidence is confronted with gender biases in the labor market regarding changing...
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Using FreeFEM open software for modelling the vibrations of piezoelectric devices
PublicationModelling vibrations of piezoelectric transducers has been a topic discussed in the literature for many decades. The first models - so-called one-dimensional - describe the vibrations only near operating frequency and near its harmonics. Attempts to introduce two-dimensional models were related to the possibility of one transducer working at several frequencies, including both thickness vibrations and those resulting from the transducer...
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Harnessing digital technologies for poverty reduction. Evidence for low-income and lower-middle income countries
PublicationThis paper contributes to understanding the relationship between ICT deployment and poverty alleviation in developing countries. It assess the digital technologies contribution to poverty reduction, through different channels of impact, like education, labor market, income and ICTtrade related activities. Using the sample of 40 developing countries between 1990 and 2019, it relies on macro data extracted from the World Bank Development...
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Economics of credit scoring management
PublicationCredit scoring models constitute an inevitable element of modern risk and profitability management in retail financial lending institutions. Quality,or separation power of a credit scoring model is usually assessed with the Gini coefficient. Generally, the higher Gini coefficient the better, as in this way a bank can increase number of good customers and/or reject more bad applicants. In...
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Failure mode prediction for composite structural insulated panels with MgO board facings
PublicationSandwich panels are readily used in civil engineering due to their high strength to weight ratio and the ease and speed of assembly. The idea of a sandwich section is to combine thin and durable facings with a light-weight core and the choice of materials used allows obtaining the desired behaviour. Panels in consideration consist of MgO (magnesium oxide) board facings and expanded polystyrene core and are characterized by immunity...
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Swarm-Assisted Investment Planning of a Bioethanol Plant
PublicationBioethanol is a liquid fuel for which a significant increase in the share of energy sources has been observed in the economies of many countries. The most significant factor in popularizing bioethanol is the profitability of investments in construction of facilities producing this energy source, as well as the profitability of its supply chain. With the market filled with a large amount of equipment used in the bioethanol production...
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Comprehensive determination of flavouring additives and nicotine in e-cigarette refill solutions. Part I: Liquid chromatography-tandem mass spectrometry analysis
PublicationLiquid chromatography-tandem mass spectrometry with electrospray ionization (HPLC-ESI–MS/MS) methods were developed for the simultaneous determination of 42 flavouring compounds and nicotine in liquids for e-cigarettes. The chromatographic separation was performed using an Ace® Ultracore™ SuperC18™ (100 × 2.1 mm, 2.5 μm) column in both acidic and alkaline pH conditions to separate all the compounds. A simple “dilute & shoot” approach...
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The role of stakeholders on rejection of bankruptcy applications in the case of “poverty” of the estate: A Polish case study
PublicationThe aim of this article is to supplement the Law and Economics area of science with regard to the scope of the ex ante effectiveness of bankruptcy law using the example of Poland. Bankruptcy law is effective in the ex ante stage when it eliminates from the market insolvent entrepreneurs who cannot even afford to cover the costs of bankruptcy proceedings. In these cases, the bankruptcy court should dismiss the petition for bankruptcy...
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Chinese Foreign Direct Investments in Europe. The Polish Case
PublicationThe first aim of this paper is to analyze the features that have motivated Chinese outbound investments in the European Union. The paper outlines also the policies adopted by the European institutions and its member states to encourage the increase of the Chinese FDI without harming the internal European market, and consequently phase out all concerns that are afflicting the European public opinion. The second purpose is more focused...
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Evaluati on of long-term start up costs impact on short-term price based operational optimization of a CCGT using MILP
PublicationAn increasing share of the weather-dependent RES generation in the power system leads to the growing importance of flexibility of conventional power plants. They were usually designed for base load operation and it is a challenge to determine the actual long-term cycling costs, which account for an increase in maintenance and overhaul expenditures, increased forced outage rates and shortened life expectancy of the plant and components....
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EMPIRICAL ASSESMENT OF THE MAIN DRIVING SYSTEM OF THE CIRCULAR SAWING MACHINE
PublicationThe producers of panel saws tend to improve sawing accuracy and minimise a level of vibrations, to increase their competitiveness at the market. Mechanical vibrations in the main saw driving system, which level depend on a plethora independent factors, may really affect sawing accuracy and general machine tool vibrations. The objective of the research was to explore vibrations signals of the main spindle system, and to extract...
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Determination of the tram track axis using a multi receiver GNSS measurement system
PublicationThis article refers to research, that has been conducted by an interdisciplinary research team from the Gdańsk University of Technology and the Maritime University in Gdynia since 2009. These investigation concerns the determination of a railway track axis using the mobile satellite measurement technique. Following the dynamic development of GNSS techniques, that could be seen in the last decade, the team carried out further experiments...
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Study on CPU and RAM Resource Consumption of Mobile Devices using Streaming Services
PublicationStreaming multimedia services have become very popular in recent years, due to the development of wireless networks. With the growing number of mobile devices worldwide, service providers offer dedicated applications that allow to deliver on-demand audio and video content anytime and everywhere. The aim of this study was to compare different streaming services and investigate their impact on the CPU and RAM resources, with respect...
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Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential
PublicationBackground The neonatal murine heart is able to regenerate after severe injury; this capacity however, quickly diminishes and it is lost within the first week of life. DNA methylation is an epigenetic mechanism which plays a crucial role in development and gene expression regulation. Under investigation here are the changes in DNA methylation and gene expression patterns which accompany the loss of regenerative potential. Results The...
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Phytoecdysteroid containing plants – a source of bioactive compounds with potential anticarcinogenic effects
PublicationEcdysteroids are a group of steroids synthesized in inver- tebrates as molting hormones and also in some plants as secondary metabolites acting as a defense against parasites. These compounds do not naturally occur in mammals and are not structurally related to mammalian steroid hor- mones, consequently do not activate mammalian hormone receptors. Ecdysteroids exhibit very low toxicity to mam- mals and to date no serious side effects...